Protein Alignment RtGEF and ARHGEF9

DIOPT Version :9

• Sequence 1: NP_001097184.2
• Gene: RtGEF / 35306
• FlyBaseID: FBgn0015803
• Length: 1310
• Species: Drosophila melanogaster
• Sequence 2: NP_001340852.1
• Gene: ARHGEF9 / 23229
• HGNCID: 14561
• Length: 529
• Species: Homo sapiens
• Alignment Length: 414
• Identity: 93/414 - (22%)
• Similarity: 178/414 - (42%)
• Gaps: 81/414 - (19%)

  Fly     2 DQPLVVQAEYSFMGSNNDELCFQKGDVITVTQREDGGWWEGTLNDKTGWFPSNYV-----NECKV 61
            |..:..:|.:..:...|.||.|:.||||.|....:..||.|.::|:.||||:::|     .|.:|
Human    21 DSIVSAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDEV 85

  Fly    62 QL-----------PLTETI---RPPEEIQEYRSVVLKDLLDSERAHVAELQGLLENFLEPMQQTQ 112
            :.           |.::.:   ||.:...:.|:.|:.:::.:||.::..|:.:.|.:|:..::.:
Human    86 EEGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRR 150

  Fly   113 ILSQDEYAQLMC-NFVEIVRTHEDLLIQIEE--CND-----RVGKLFLTSAPLMKKVHQ------ 163
            .:..||..:::. |..:|.|.....:..:|:  .||     .:|..||.        ||
Human   151 DMFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLE--------HQDGFWIY 207

  Fly   164 -AYCAAHPKAIVILDK-YKDE-----------LEKYMERQGAATPGLLVLTTGLSKPFRRLDKYS 215
             .||..|..|.:.|.| .||.           |::.::   .|..|.|:      .|.:::.||.
Human   208 SEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMID---IAIDGFLL------TPVQKICKYP 263

  Fly   216 AMLQELERHMESSHPDRGDTQRSVAVYKDIAATCSATRRQKELE----LQVLTGPVRGWQGQE-L 275
            ..|.||.::....|.|......::||.:::  |.....|::.||    :......|..|:|:: |
Human   264 LQLAELLKYTAQDHSDYRYVAAALAVMRNV--TQQINERKRRLENIDKIAQWQASVLDWEGEDIL 326

  Fly   276 STLGDIIHMGSVA-----VGADHRDRYFVLFPQTLLFLSVSQRMSAFIYEGKLPLTGIIVNRLED 335
            ....::|:.|.:|     .|.:.:..:|:...|.:|......|.....|:|::.:....|..:||
Human   327 DRSSELIYTGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIED 391

  Fly   336 ------TDALKNAFEISSPLIDRI 353
                  ..::||||::.:...:.|
Human   392 GRDDDFNVSMKNAFKLHNKETEEI 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RtGEF	NP_001097184.2	SH3_PIX	6..58	CDD:212810	19/56 (34%)
		RhoGEF	79..249	CDD:238091	42/196 (21%)
		PH_Cool_Pix	281..376	CDD:269932	18/84 (21%)
ARHGEF9	NP_001340852.1	SH3_ARHGEF9	20..81	CDD:212908	20/59 (34%)
		RhoGEF	120..299	CDD:214619	42/197 (21%)
		PH_Collybistin_ASEF	304..443	CDD:269931	24/112 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910