Protein Alignment RtGEF and Arhgef4

DIOPT Version :9

• Sequence 1: NP_001097184.2
• Gene: RtGEF / 35306
• FlyBaseID: FBgn0015803
• Length: 1310
• Species: Drosophila melanogaster
• Sequence 2: NP_001355702.1
• Gene: Arhgef4 / 226970
• MGIID: 2442507
• Length: 1855
• Species: Mus musculus
• Alignment Length: 521
• Identity: 109/521 - (20%)
• Similarity: 206/521 - (39%)
• Gaps: 124/521 - (23%)

  Fly     6 VVQAE--YSFMGSNNDELCFQKGDVITVTQREDGGWWEGTLNDKTGWFPSNYV------------ 56
            ||.||  :..:..::.||.|:.||||.|....:..||.|.:.|..||||:::|
Mouse  1360 VVCAEALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRLRVNQDEPADD 1424

  Fly    57 ------------------NECKVQLPLTETIRPPEEIQEYRSVVLKDLLDSERAHVAELQGLLEN 103
                              ..||.|:               |:.|:.::|.:||.::..|:.:.|.
Mouse  1425 YEAPRAGAREADDSGPEAQSCKDQM---------------RTNVINEILSTERDYIKHLRDICEG 1474

  Fly   104 FLEPMQQTQ-ILSQDEYAQLMCNFVEIVRTHEDLLIQIEECNDRVGKLFLTSAPLMKKV------ 161
            ::...::.: :.|:::...:..|..:|.|..:..:..:|:       .|.|..|.:.::
Mouse  1475 YVRQCRKREDMFSEEQLRTIFGNIEDIYRCQKAFVKALEQ-------KFNTERPHLSELGACFLE 1532

  Fly   162 HQA-------YCAAHPKAIVILDKYKDELEKY---------MERQ-GAATPGLLVLTTGLSKPFR 209
            |||       ||..||.|.|.|.:. .:|.||         ::|. ..:..|.|:      .|.:
Mouse  1533 HQADFQIYSEYCNNHPNACVELSRL-TKLSKYVYFFEACRLLQRMIDISLDGFLL------TPVQ 1590

  Fly   210 RLDKYSAMLQELERHMESSHPDRGDTQRSVAVYKDIAATCSATRRQKEL--ELQVLTGPVRGWQG 272
            ::.||...|.||.::....|.|..:.:.::...|::|...:..:|:.|.  ::......:..|:|
Mouse  1591 KICKYPLQLAELLKYTHPQHRDFKNVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEG 1655

  Fly   273 QELST-LGDIIHMGSVA----VGADHRDRYFVLFPQTLLFLSVS-QRMSAFIYEGKLPLTGIIVN 331
            ::|.. ..::||.|.:.    ..|..:.|.|.||.:.|::.... .|.....|:|:|.:..:.|.
Mouse  1656 EDLLVRSSELIHSGELTRVTQPQARSQQRMFFLFDRQLIYCKKDLLRRDVLYYKGRLDMDDLEVV 1720

  Fly   332 RLEDTD------ALKNAFEI-SSPLIDRIVAVCQGPNEANKWVELLNANNPSLPMG--------- 380
            .:||..      ::||||.: .....|..:...:.|.:..:|::........:.:.
Mouse  1721 DVEDGKDRDLHVSVKNAFRLYCGTTGDSHLLCARKPEQKQRWLKAFAREREQVRLDQETGFSITE 1785

  Fly   381 IKRQLSNLSNSSLGHLNAAHLSQHLDSRGYCTRFSLCAYYSSPPCHVRPLRVTL-------PPSN 438
            ::|:.:.|:.|.   ..|....:.:...||.||..    :.|.|.. ||.:..|       .|||
Mouse  1786 LQRKQAMLNASK---QQATGKPKAVGRPGYLTRHK----HPSLPAS-RPQQQVLVLAEPRRKPSN 1842

  Fly   439 Y 439
            :
Mouse  1843 F 1843

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RtGEF	NP_001097184.2	SH3_PIX	6..58	CDD:212810	21/83 (25%)
		RhoGEF	79..249	CDD:238091	41/193 (21%)
		PH_Cool_Pix	281..376	CDD:269932	23/106 (22%)
Arhgef4	NP_001355702.1	SH3_ASEF	1344..1416	CDD:212906	21/55 (38%)
		RhoGEF	1450..1631	CDD:238091	41/194 (21%)
		PH_Collybistin_ASEF	1637..1776	CDD:269931	27/138 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910