DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RtGEF and pix-1

DIOPT Version :9

Sequence 1:	NP_001097184.2	Gene:	RtGEF / 35306	FlyBaseID:	FBgn0015803	Length:	1310	Species:	Drosophila melanogaster
Sequence 2:	NP_001257227.1	Gene:	pix-1 / 181490	WormBaseID:	WBGene00010776	Length:	646	Species:	Caenorhabditis elegans

Alignment Length:	754	Identity:	197/754 - (26%)
Similarity:	316/754 - (41%)	Gaps:	184/754 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PLVVQAEYSFMGSNNDELCFQKGDVITVTQREDGGWWEGTLNDKTGWFPSNYV----NECKVQLP 64
            ||..:|::.|.|||||||.|.|.|:||:||:::|||||||....|||||..||    .:.|:|..
Worm     8 PLSARAKFQFEGSNNDELSFDKDDIITITQQQEGGWWEGTHEGVTGWFPCAYVTLITEKDKLQRS 72

  Fly    65 LTETIRPPEEI------QEYRSVVLKDLLDSERAHVAELQGLLENFLEPMQQTQILSQDEYAQLM 123
            .:......:|:      .:||.:|||..::||:.::..|...|::.|.|:..::||:..||..|:
Worm    73 RSVPNATAKEVVSVGAQPDYRDLVLKSYIESEKEYMQSLLKTLQSLLIPIGASKILTAPEYCTLV 137

  Fly   124 CNFVEIVRTHEDLLIQIE-ECND-----RVGKLFLTSAPLMKKVHQAYCAAHPKAIVILDKYKDE 182
            .||..|.....||..|:| |.|:     |||.:|:.:|..::....:|...||.|:.:|.|.:.|
Worm   138 GNFEVIYTLKRDLFEQLEREQNEELPKMRVGGMFMNAALELRTALMSYADNHPDAVEVLKKKQKE 202

  Fly   183 LEKYMERQGAATPGLLVLTTGLSKPFRRLDKYSAMLQELERHMESSHPDRGDTQRSVAVYKDIAA 247
            |||.::.|......|::   |||:|.|.:::|..:||||||.:.::||||||.||..||:::...
Worm   203 LEKVVKSQDREYKELVL---GLSEPLRHVERYYNLLQELERIVPANHPDRGDLQRGSAVFRETKD 264

  Fly   248 TCSATRRQKELEL---------QVLTGPVRGWQGQELSTLGDIIHMGSVAV---GADHRDRYFVL 300
            .|...|:|||.:|         :|::...|          |.|:::|...|   .||..||:..|
Worm   265 LCETLRKQKEAQLDFLFVSKVDKVVSASER----------GSILYVGVANVEYKKADAVDRFVAL 319

  Fly   301 FPQTLLFLSVSQRMSAFIYEGKLPLTGIIVNRLEDTDALKNAFEISSPLIDR-------IVAVCQ 358
            |.:.::|..|::.|:..|.| |..::|.||.:       |.|.|||   .||       :..|..
Worm   320 FTKYIMFFEVTKDMTYDIKE-KFTVSGFIVRK-------KEATEIS---FDRPNTGEFTLTMVST 373

  Fly   359 GPNEANKWVELLNANNPSL---PMGIKRQLSNLSNSSLGHLNAAHLSQHLDSRGYCTRFSLCAYY 420
            |.......|.|..|.|.::   ...|.|:.|..:|.::..      ||        |:.:.....
Worm   374 GGEVERFLVALAKAENVAIITPTTTILRRPSKNANDTMNQ------SQ--------TQGAETPLV 424

  Fly   421 SSPPCHVRPLRVTLPPSNYPATAPYANLSAHFARLVKGGGLRSAIVKMLLYPQARQSIDLKRIAL 485
            :.||.|        ||.|                                       .|.:...:
Worm   425 AKPPLH--------PPGN---------------------------------------SDQQYSMM 442

  Fly   486 RKRRCHK---ASAKLKDLNTNQDSGQSELERQDAIELPTDSESYDDDFEDDFLHSCDSDPFEYVQ 547
            .||:..|   .|..|.::..:.:.|   :...:..||||.|.:..:          .:|..::.|
Worm   443 NKRKSSKNFDDSLNLGNMKFDHELG---MVLPEGFELPTSSRNSRN----------TADNLQFSQ 494

  Fly   548 FYQNKRNDSMCNSTGTFVDHGTGARRHCSSINLIKLDSADTDEVLALNELKKESLVIGSRALRAL 612
            |             .:|...|...:|...:|.|.|  .|..||     |::.|:|    |.|...
Worm   495 F-------------PSFFLSGNAGKRGDRNIRLRK--DAARDE-----EIEFETL----RILEGY 535

  Fly   613 ARKSTTRNSSVHTSTA--------------TLELGVGGSITNCVEEEPIL----KVKPSFS-LQQ 658
            ..::....|..|.:.:              .:|..:|..:.  ::|:.|:    .:|...| ||.
Worm   536 CVETGGGQSDFHANESYQQPHLIVAEDEKILMEEMIGDEVV--LQEKSIVDAVYAIKDQLSFLQT 598

  Fly   659 QSSDASSIFAARLGGAFTACENLASMPDDLSRESSIQEP 697
            :....:.:..:..........||..|...:|.:.|...|
Worm   599 EFQKLAKVVESEQKARRRLEHNLPKMSGVISPDGSSSTP 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RtGEF	NP_001097184.2	SH3_PIX	6..58	CDD:212810	30/55 (55%)
		RhoGEF	79..249	CDD:238091	63/175 (36%)
		PH_Cool_Pix	281..376	CDD:269932	31/104 (30%)
pix-1	NP_001257227.1	SH3_PIX	11..62	CDD:212810	30/50 (60%)
		RhoGEF	93..261	CDD:238091	63/170 (37%)
		betaPIX_CC	550..635	CDD:293131	13/86 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158304
Domainoid	1	1.000	99	1.000	Domainoid score	I4486
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D251777at33208
OrthoFinder	1	1.000	-	-		FOG0002550
OrthoInspector	1	1.000	-	-		oto17455
orthoMCL	1	0.900	-	-		OOG6_103985
Panther	1	1.100	-	-	LDO	PTHR46026
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3079
SonicParanoid	1	1.000	-	-		X1675
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.880