Protein Alignment RtGEF and Arhgef7

DIOPT Version :10

• Sequence 1: NP_001097184.2
• Gene: RtGEF / 35306
• FlyBaseID: FBgn0015803
• Length: 1310
• Species: Drosophila melanogaster
• Sequence 2: XP_008769602.3
• Gene: Arhgef7 / 114559
• RGDID: 620624
• Length: 901
• Species: Rattus norvegicus
• Alignment Length: 554
• Identity: 213/554 - (38%)
• Similarity: 318/554 - (57%)
• Gaps: 77/554 - (13%)

  Fly     5 LVVQAEYSFMGSNNDELCFQKGDVITVTQREDGGWWEGTLNDKTGWFPSNYVNECKVQ----LPL 65
            |||:|:::|..:|.|||.|.|||||.||:.|:|||||||.|.:|||||||||.|.|..    .|.
  Rat   205 LVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTHNGRTGWFPSNYVREIKPSEKPVSPK 269

  Fly    66 TETIR-PPEEI------QEYRSVVLKDLLDSERAHVAELQGLLENFLEPMQQTQILSQDEYAQLM 123
            :.|:: ||:..      :.|.:|||:::|::|..:..|||.:|..:|.|:|.::.||....:.||
  Rat   270 SGTLKSPPKGFDTTAINKSYYNVVLQNILETEHEYSKELQSVLSTYLWPLQTSEKLSSANTSYLM 334

  Fly   124 CNFVEIVRTHEDLLIQIEEC------NDRVGKLFLTSAPLMKKVHQAYCAAHPKAIVILDKYKDE 182
            .|..||....:.|:..:|||      ..|||..||:..|.|:.::.||||.||.|:.:|.::.::
  Rat   335 GNLEEISSFQQVLVQSLEECTKSPEAQQRVGGCFLSLMPQMRTLYLAYCANHPSAVSVLTEHSED 399

  Fly   183 LEKYMERQGAATPGLLVLTTGLSKPFRRLDKYSAMLQELERHMESSHPDRGDTQRSVAVYKDIAA 247
            |.::||.:||::||:|||||||||||.|||||..:|:|||||||..||||.|.|:|:..:|:::|
  Rat   400 LGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHPDRQDIQKSMTAFKNLSA 464

  Fly   248 TCSATRRQKELELQVLTGPVRGWQGQELSTLGDIIHMGSVAV---GADHR-DRYFVLFPQTLLFL 308
            .|...|::||||||:||.|:|.|:|.::.|||.:.:|..|.:   |::.: :||.:|||..||.|
  Rat   465 QCQEVRKRKELELQILTEPIRSWEGDDIKTLGSVTYMSQVTIQCAGSEEKNERYLLLFPNLLLML 529

  Fly   309 SVSQRMSAFIYEGKLPLTGIIVNRLEDTDALKNAFEISSPLIDRIVAVCQGPNEANKWVELLNAN 373
            |.|.|||.|||:||||.||:.:.:|||::..:||||||..:|:||:..|....:.::|||.|..
  Rat   530 SASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLHEWVEHLQR- 593

  Fly   374 NPSLPMGIKRQLSNLSNSSL------GHLNAAH----LSQHLDSRGYCTRFSLCAYYSSP-PCHV 427
                    :.:::::||.::      .|...:|    .|:|.||:....   ..||::.| |.|.
  Rat   594 --------QTKVTSVSNPTIKPHSVPSHTLPSHPLTPSSKHADSKPVAL---TPAYHTLPHPSHH 647

  Fly   428 RPLRVTLP--PSNYPATAPYANLSAHFARLVKGGGLRSAIVKMLLYPQARQSIDLKRIALRKRRC 490
            .....|:.  |...|.|....:||.          ||.|       |..|.|..|         |
  Rat   648 GTPHTTISWGPLEPPKTPKPWSLSC----------LRPA-------PPLRPSAAL---------C 686

  Fly   491 HKASAKLKDLNTNQDSGQSELERQDAIELPTDSE 524
            :|     :||:.:..:.:..|.::.....|:|.|
  Rat   687 YK-----EDLSRSPKTMKKLLPKRKPERKPSDEE 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RtGEF	NP_001097184.2	SH3_PIX	6..58	CDD:212810	34/51 (67%)
		RhoGEF	79..249	CDD:238091	78/175 (45%)
		PH_Cool_Pix	281..376	CDD:269932	42/98 (43%)
Arhgef7	XP_008769602.3	None