DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RtGEF and Arhgef7

DIOPT Version :9

Sequence 1:	NP_001097184.2	Gene:	RtGEF / 35306	FlyBaseID:	FBgn0015803	Length:	1310	Species:	Drosophila melanogaster
Sequence 2:	XP_008769601.2	Gene:	Arhgef7 / 114559	RGDID:	620624	Length:	930	Species:	Rattus norvegicus

Alignment Length:	554	Identity:	213/554 - (38%)
Similarity:	318/554 - (57%)	Gaps:	77/554 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LVVQAEYSFMGSNNDELCFQKGDVITVTQREDGGWWEGTLNDKTGWFPSNYVNECKVQ----LPL 65
            |||:|:::|..:|.|||.|.|||||.||:.|:|||||||.|.:|||||||||.|.|..    .|.
  Rat   234 LVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTHNGRTGWFPSNYVREIKPSEKPVSPK 298

  Fly    66 TETIR-PPEEI------QEYRSVVLKDLLDSERAHVAELQGLLENFLEPMQQTQILSQDEYAQLM 123
            :.|:: ||:..      :.|.:|||:::|::|..:..|||.:|..:|.|:|.::.||....:.||
  Rat   299 SGTLKSPPKGFDTTAINKSYYNVVLQNILETEHEYSKELQSVLSTYLWPLQTSEKLSSANTSYLM 363

  Fly   124 CNFVEIVRTHEDLLIQIEEC------NDRVGKLFLTSAPLMKKVHQAYCAAHPKAIVILDKYKDE 182
            .|..||....:.|:..:|||      ..|||..||:..|.|:.::.||||.||.|:.:|.::.::
  Rat   364 GNLEEISSFQQVLVQSLEECTKSPEAQQRVGGCFLSLMPQMRTLYLAYCANHPSAVSVLTEHSED 428

  Fly   183 LEKYMERQGAATPGLLVLTTGLSKPFRRLDKYSAMLQELERHMESSHPDRGDTQRSVAVYKDIAA 247
            |.::||.:||::||:|||||||||||.|||||..:|:|||||||..||||.|.|:|:..:|:::|
  Rat   429 LGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHPDRQDIQKSMTAFKNLSA 493

  Fly   248 TCSATRRQKELELQVLTGPVRGWQGQELSTLGDIIHMGSVAV---GADHR-DRYFVLFPQTLLFL 308
            .|...|::||||||:||.|:|.|:|.::.|||.:.:|..|.:   |::.: :||.:|||..||.|
  Rat   494 QCQEVRKRKELELQILTEPIRSWEGDDIKTLGSVTYMSQVTIQCAGSEEKNERYLLLFPNLLLML 558

  Fly   309 SVSQRMSAFIYEGKLPLTGIIVNRLEDTDALKNAFEISSPLIDRIVAVCQGPNEANKWVELLNAN 373
            |.|.|||.|||:||||.||:.:.:|||::..:||||||..:|:||:..|....:.::|||.|..
  Rat   559 SASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLHEWVEHLQR- 622

  Fly   374 NPSLPMGIKRQLSNLSNSSL------GHLNAAH----LSQHLDSRGYCTRFSLCAYYSSP-PCHV 427
                    :.:::::||.::      .|...:|    .|:|.||:....   ..||::.| |.|.
  Rat   623 --------QTKVTSVSNPTIKPHSVPSHTLPSHPLTPSSKHADSKPVAL---TPAYHTLPHPSHH 676

  Fly   428 RPLRVTLP--PSNYPATAPYANLSAHFARLVKGGGLRSAIVKMLLYPQARQSIDLKRIALRKRRC 490
            .....|:.  |...|.|....:||.          ||.|       |..|.|..|         |
  Rat   677 GTPHTTISWGPLEPPKTPKPWSLSC----------LRPA-------PPLRPSAAL---------C 715

  Fly   491 HKASAKLKDLNTNQDSGQSELERQDAIELPTDSE 524
            :|     :||:.:..:.:..|.::.....|:|.|
  Rat   716 YK-----EDLSRSPKTMKKLLPKRKPERKPSDEE 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RtGEF	NP_001097184.2	SH3_PIX	6..58	CDD:212810	34/51 (67%)
		RhoGEF	79..249	CDD:238091	78/175 (45%)
		PH_Cool_Pix	281..376	CDD:269932	42/98 (43%)
Arhgef7	XP_008769601.2	CH_betaPIX	71..183	CDD:409115
		RhoGEF67_u1	185..231	CDD:406911
		SH3_betaPIX	235..288	CDD:212994	34/52 (65%)
		RhoGEF	319..496	CDD:238091	78/176 (44%)
		PH_Cool_Pix	527..625	CDD:269932	42/106 (40%)
		RhoGEF67_u2	681..779	CDD:374671	21/95 (22%)
		betaPIX_CC	841..927	CDD:406829
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	158	1.000	Domainoid score	I4030
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D251777at33208
OrthoFinder	1	1.000	-	-		FOG0002550
OrthoInspector	1	1.000	-	-		otm44386
orthoMCL	1	0.900	-	-		OOG6_103985
Panther	1	1.100	-	-	O	PTHR46026
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1675
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.920