DRSC/TRiP Functional Genomics Resources

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Protein Alignment RtGEF and VAV3

DIOPT Version :10

Sequence 1:NP_001097184.2 Gene:RtGEF / 35306 FlyBaseID:FBgn0015803 Length:1310 Species:Drosophila melanogaster
Sequence 2:NP_006104.4 Gene:VAV3 / 10451 HGNCID:12659 Length:847 Species:Homo sapiens


Alignment Length:379 Identity:86/379 - (22%)
Similarity:156/379 - (41%) Gaps:75/379 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 SNNDELCFQKG--DVITVTQREDGGWWEGTLNDKTGWFPSNYVNECKVQLPLTETIRPPE-EIQE 77
            |.|||..: ||  |:|..|..||    |..|.|..  :..:...|....|...|....|: ...:
Human   134 SINDEDIY-KGLPDLIDETLVED----EEDLYDCV--YGEDEGGEVYEDLMKAEEAHQPKCPEND 191

  Fly    78 YRSVVLKDLLDSERAHVAELQGLLENFLEPMQQTQILSQDEYAQLMCNFVEIVRTHEDLLIQIEE 142
            .||..|.::..:|..:...|:.:.:.|:.|::  :.|:..|:..:..|..|:|:.|.:|:.:|.:
Human   192 IRSCCLAEIKQTEEKYTETLESIEKYFMAPLK--RFLTAAEFDSVFINIPELVKLHRNLMQEIHD 254

  Fly   143 C----NDR-VGKLFLTSAPLMKKVHQAYCAAHPKAIVILD---KYKDELE-KYMERQGAATPGLL 198
            .    ||: :.::|:.....: .::..||:....||..||   |.|:::: |..|....|..|..
Human   255 SIVNKNDQNLYQVFINYKERL-VIYGQYCSGVESAISSLDYISKTKEDVKLKLEECSKRANNGKF 318

  Fly   199 VLTTGLSKPFRRLDKYSAMLQELERHMESSHP-DRGDTQRSVAVYKDIAATCSATRRQKE----- 257
            .|...|..|.:|:.||..:||||.:|  ::.| ::.:.:.::...||:|...:..:|..|     
Human   319 TLRDLLVVPMQRVLKYHLLLQELVKH--TTDPTEKANLKLALDAMKDLAQYVNEVKRDNETLREI 381

  Fly   258 ----LELQVLTGPVRGWQGQELSTLGDIIHMGSVAVGADHRDRYFVLFPQTLLFLSVSQRMSAFI 318
                |.::.|..||..:...:    ||    |.:.:              |.|.....|....|:
Human   382 KQFQLSIENLNQPVLLFGRPQ----GD----GEIRI--------------TTLDKHTKQERHIFL 424

  Fly   319 YEGKLPLTGIIVNRLEDTDALKNAFEI------SSPLIDRIVAVCQGPNEANKW 366
            ::    |..|:..|..|...:|...::      ::|..|:         |..||
Human   425 FD----LAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDK---------ENKKW 465

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RtGEFNP_001097184.2 SH3_PIX 6..58 CDD:212810 14/43 (33%)
RhoGEF 79..249 CDD:238091 45/179 (25%)
PH_Cool_Pix 281..376 CDD:269932 15/92 (16%)
VAV3NP_006104.4 CH_VAV3 2..118 CDD:409113
RhoGEF 193..369 CDD:238091 45/180 (25%)
PH_Vav 383..506 CDD:269930 21/118 (18%)
C1_VAV3 506..564 CDD:410419
Sufficient for interaction with ROS1. /evidence=ECO:0000269|PubMed:11094073 560..847
SH3_VAV3_1 596..657 CDD:212914
SH2_Vav3 666..768 CDD:198270
SH3_VAV3_2 791..846 CDD:212911
Blue background indicates that the domain is not in the aligned region.

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