DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RtGEF and arhgef6

DIOPT Version :9

Sequence 1:	NP_001097184.2	Gene:	RtGEF / 35306	FlyBaseID:	FBgn0015803	Length:	1310	Species:	Drosophila melanogaster
Sequence 2:	XP_012825042.2	Gene:	arhgef6 / 100489192	XenbaseID:	XB-GENE-949773	Length:	777	Species:	Xenopus tropicalis

Alignment Length:	669	Identity:	228/669 - (34%)
Similarity:	334/669 - (49%)	Gaps:	111/669 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LVVQAEYSFMGSNNDELCFQKGDVITVTQREDGGWWEGTLNDKTGWFPSNYVNECKV-QLPLT-E 67
            |||:|.::|...|.|||.|.|||.|.|::.|||||||||||.|:||||||||.|.|. ..||: :
Frog   164 LVVKARFNFNQQNEDELSFCKGDTIYVSRVEDGGWWEGTLNGKSGWFPSNYVKEFKSNDKPLSPK 228

  Fly    68 TIRPPEEIQ---EYRSVVLKDLLDSERAHVAELQGLLENFLEPMQQTQILSQDEYAQLMCNFVEI 129
            .::..|..|   .|.:|||:::|::||::..|||.||..:|.|:|....:|..:.:.|:.||.||
Frog   229 AVKACETAQLTKNYYTVVLQNILETERSYAKELQLLLSTYLRPLQSHDKISTVDVSSLLGNFEEI 293

  Fly   130 VRTHEDLLIQIEEC------NDRVGKLFLTSAPLMKKVHQAYCAAHPKAIVILDKYKDELEKYME 188
            ....:.|...:|||      :.:||...|........::.:||:.||.|:.:|.:..|||..:||
Frog   294 CTFQQTLCQALEECAKLPENHQKVGGCLLNLFNQFMSLYLSYCSNHPMAVHVLTQQSDELGTFME 358

  Fly   189 RQGAATPGLLVLTTGLSKPFRRLDKYSAMLQELERHMESSHPDRGDTQRSVAVYKDIAATCSATR 253
            .|||..||:|:|||.|||||.||:||..:|||||||||.:|||..|..::.|.:|.:...|...|
Frog   359 NQGAPVPGILMLTTSLSKPFIRLEKYVTLLQELERHMEEAHPDHKDILKATAAFKTLVTQCQDLR 423

  Fly   254 RQKELELQVLTGPVRGWQGQELSTLGDIIHMGSVAV----GADHRDRYFVLFPQTLLFLSVSQRM 314
            ::|:||||:|:..::||:|:::.|||..:.|..|.|    ..:..:|||:|||..||.||.|.||
Frog   424 KRKQLELQILSESIQGWEGEDIKTLGTAVFMSQVMVQCGTNEEKEERYFMLFPNALLMLSASPRM 488

  Fly   315 SAFIYEGKLPLTGIIVNRLEDTDALKNAFEISSPLIDRIVAVCQGPNEANKWVELLNANNPSLPM 379
            |.|||:|||||||:.|.:||:.|...:.|||:..:|:|||..|...::..:|:|
Frog   489 SGFIYQGKLPLTGMSVVKLEENDTTNHGFEIAGTMIERIVVYCNNSHDCQEWLE----------- 542

  Fly   380 GIKRQLSNLSNSSLGHLNAAHLSQHLDSRGYCTRFSLCAYYSSPPCHVRPLRVTLPPSNYPATAP 444
                                ||  |..::|..:..|||...|.....:.. |..||||:|..| |
Frog   543 --------------------HL--HRLTKGTGSHASLCKTQSLTSTSLTE-RKQLPPSHYSVT-P 583

  Fly   445 YANLSAHFARLVKG---GGLRSAIVKMLLYPQARQSIDLKRIALRKRRCHKASAKLKDLNTNQDS 506
            ...|..  |:|.|.   ..||.|       |..|.|..|   ..::|    .|...||.:.:..:
Frog   584 RGPLEP--AKLYKAWTLSCLRPA-------PPLRPSYAL---GYKER----MSYIFKDSSKSPKN 632

  Fly   507 GQSELERQDAIELPTDSESYDDDFEDDFLHSC-----DSDPFEYVQFYQNKRNDSMCNSTGTFVD 566
            .:..|.::.....|:|.:|       .|..|.     |:...:.::.|        |...|....
Frog   633 VKKFLPKRKTERKPSDEDS-------GFRKSTVALEEDAQILKVIEAY--------CTGAGFQQS 682

  Fly   567 HGTGARRHCSSINLIKLDSADTDEVLALNELKKESLVIGSRALRALARKSTTRNSSVHTSTA--- 628
            ..:|:|:               |.|..:..|::|:|:|..  ||...:..:...|.|.|..|
Frog   683 LCSGSRK---------------DSVAQVLLLEEENLIIDE--LRTNGQTVSEEKSLVDTVYALRD 730

  Fly   629 -TLELGVGGS-ITNCVEEE 645
             .:||..... :..|::||
Frog   731 EVMELKQENKRMKQCLDEE 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RtGEF	NP_001097184.2	SH3_PIX	6..58	CDD:212810	34/51 (67%)
		RhoGEF	79..249	CDD:238091	71/175 (41%)
		PH_Cool_Pix	281..376	CDD:269932	41/98 (42%)
arhgef6	XP_012825042.2	CH_alphaPIX	1..117	CDD:409114
		RhoGEF67_u1	115..161	CDD:406911
		SH3_alphaPIX	163..220	CDD:212993	36/55 (65%)
		RhoGEF	243..420	CDD:238091	71/176 (40%)
		PH_Cool_Pix	452..549	CDD:269932	44/129 (34%)
		RhoGEF67_u2	578..685	CDD:374671	28/138 (20%)
		betaPIX_CC	688..774	CDD:406829	18/79 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	158	1.000	Domainoid score	I4070
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D251777at33208
OrthoFinder	1	1.000	-	-		FOG0002550
OrthoInspector	1	1.000	-	-		otm47432
Panther	1	1.100	-	-	LDO	PTHR46026
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1675
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.020