DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RtGEF and arhgef7

DIOPT Version :9

Sequence 1:	NP_001097184.2	Gene:	RtGEF / 35306	FlyBaseID:	FBgn0015803	Length:	1310	Species:	Drosophila melanogaster
Sequence 2:	XP_012813343.1	Gene:	arhgef7 / 100145259	XenbaseID:	XB-GENE-962606	Length:	861	Species:	Xenopus tropicalis

Alignment Length:	826	Identity:	254/826 - (30%)
Similarity:	396/826 - (47%)	Gaps:	187/826 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LVVQAEYSFMGSNNDELCFQKGDVITVTQREDGGWWEGTLNDKTGWFPSNYVNECKVQ----LPL 65
            :||:|:::|..:|.|||.|.|||:|.||:.|:|||||||.:.||||||||||.|.|..    .|.
Frog   165 MVVRAKFNFQQTNEDELSFNKGDLIHVTRLEEGGWWEGTHSGKTGWFPSNYVREVKSSEKPVSPK 229

  Fly    66 TETIR-PPEEI------QEYRSVVLKDLLDSERAHVAELQGLLENFLEPMQQTQILSQDEYAQLM 123
            :.|:: ||:..      :.|.:|||:::||:|..:..|||.:|.|:|..:|.::.||....:.|:
Frog   230 STTLKSPPKGFDTSAINKSYYNVVLQNILDTEGEYSKELQDILSNYLRHLQTSEKLSPTNISYLL 294

  Fly   124 CNFVEIVRTHEDLLIQIEEC------NDRVGKLFLTSAPLMKKVHQAYCAAHPKAIVILDKYKDE 182
            .|..||....:.|:..:|||      ..|||..|::..|.||.::.||||.||.|:.:|.::.:|
Frog   295 GNLEEICAFQQILVQSLEECTKLPEGQQRVGGCFMSLMPQMKSLYIAYCANHPSAVNVLTQHSEE 359

  Fly   183 LEKYMERQGAATPGLLVLTTGLSKPFRRLDKYSAMLQELERHMESSHPDRGDTQRSVAVYKDIAA 247
            |.::||.:||.:||:|||||||||||.|||||..:|:|||||||..||||.|.|:|:..:|:::|
Frog   360 LGEFMEMKGANSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHPDRPDIQKSMTAFKNLSA 424

  Fly   248 TCSATRRQKELELQVLTGPVRGWQGQELSTLGDIIHMGSVAV---GADHR-DRYFVLFPQTLLFL 308
            .|...|::||||||:||..:|||:|:::.|||.:|:|..|.:   |::.: :||.:|||..||.|
Frog   425 QCQEVRKRKELELQILTETIRGWEGEDIKTLGTVIYMSQVMIQCAGSEEKNERYLLLFPNVLLML 489

  Fly   309 SVSQRMSAFIYEGKLPLTGIIVNRLEDTDALKNAFEISSPLIDRIVAVCQGPNEANKWVELLNAN 373
            |.|.|||.|||:||:||||:.|.:|||.:..|||:||:..:|:||:..|....:..:||:.|:.
Frog   490 SASPRMSGFIYQGKIPLTGMCVTKLEDNENHKNAYEIAGNMIERIIVSCNNQQDLQEWVDYLHK- 553

  Fly   374 NPSLPMGIKRQLSNLSNSSLGHLNAAHLSQHLDSRGYCTRFSLCAYYSSPPCHVRPLRVTLPPSN 438
                    :.:.::|.|.:        :..|                 |.|||..|.....|.|.
Frog   554 --------QTKYTSLINPT--------IKPH-----------------SVPCHTLPSHPVTPSSK 585

  Fly   439 Y------PATAPY---ANLSAHFARLVKGGGLRSAIVKMLLYPQARQ---SIDLKRIA--LRKRR 489
            :      |.|..|   .:||.|       |...|.|....|.|....   |:...|.|  ||...
Frog   586 HSDCKLMPLTPAYHTLPHLSHH-------GTPHSTISWSPLEPPKTPKPWSLSCLRPAPPLRPSA 643

  Fly   490 --CHKASAKLKDLNTNQDSGQSELERQDAIELPTDSE----SYDDDFEDDFLHSCDSDPFEYVQF 548
              |:|     :||:.:..:.:..|.::.....|:|.|    ......|:      |:...:.::.
Frog   644 ALCYK-----EDLSKSPKTMKKLLPKRKPERKPSDEEFALRKSTAALEE------DAQILKVIEA 697

  Fly   549 Y-QNKRNDSMCNST--GTFVDHGTGARRHCSSINLIKLDSADTDEVLALNELKKESLVIGSRALR 610
            | .:.:.....|||  ||.:.|     .|.         .||.|:                .:|.
Frog   698 YCTSAKTRQTLNSTWQGTDLMH-----NHV---------LADDDQ----------------SSLD 732

  Fly   611 ALARKSTTRNSSVHTSTATLELGVGGSITNCVEEEPILKVKPSFSLQQQSSDASSIFAA---RLG 672
            :|.|:|:                             :.:::||.  ..:.||..||:.|   |:|
Frog   733 SLGRRSS-----------------------------LSRLEPSD--LSEDSDYDSIWTAHSYRMG 766

  Fly   673 GAFTACENLASMPDDLSRESS---IQEPPTPLPASPTERHSMPTIFVGNRFNHSKNTEVYVPTWR 734
            .. :.|.. .|.|..|..|..   ::|..:.......|:..:.|::.
Frog   767 ST-SRCRK-GSTPQVLLPEEEKIIVEETRSNGQTVIEEKSLVDTVYA------------------ 811

  Fly   735 DRQEMQNQSVDAKQDEELHSSSIDLPAACLSAPDKLQAELLYNYDE 780
                ::::..:.|||.:....|::.........:||..::|.|.::
Frog   812 ----LKDEVQELKQDSKKMKKSLEEEQRARKELEKLIRKVLKNMND 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RtGEF	NP_001097184.2	SH3_PIX	6..58	CDD:212810	33/51 (65%)
		RhoGEF	79..249	CDD:238091	79/175 (45%)
		PH_Cool_Pix	281..376	CDD:269932	42/98 (43%)
arhgef7	XP_012813343.1	CH	21..100	CDD:237981
		RhoGEF67_u1	116..162	CDD:293221
		SH3_betaPIX	166..219	CDD:212994	33/52 (63%)
		RhoGEF	250..427	CDD:238091	79/176 (45%)
		PH_Cool_Pix	458..556	CDD:269932	42/106 (40%)
		PH	476..556	CDD:278594	38/88 (43%)
		RhoGEF67_u2	615..710	CDD:293220	18/105 (17%)
		betaPIX_CC	772..858	CDD:293131	15/105 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	158	1.000	Domainoid score	I4070
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D251777at33208
OrthoFinder	1	1.000	-	-		FOG0002550
OrthoInspector	1	1.000	-	-		otm47432
Panther	1	1.100	-	-	O	PTHR46026
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1675
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.020