Protein Alignment RtGEF and arhgef7

DIOPT Version :10

• Sequence 1: NP_001097184.2
• Gene: RtGEF / 35306
• FlyBaseID: FBgn0015803
• Length: 1310
• Species: Drosophila melanogaster
• Sequence 2: XP_012813343.1
• Gene: arhgef7 / 100145259
• XenbaseID: XB-GENE-962606
• Length: 861
• Species: Xenopus tropicalis
• Alignment Length: 826
• Identity: 254/826 - (30%)
• Similarity: 396/826 - (47%)
• Gaps: 187/826 - (22%)

  Fly     5 LVVQAEYSFMGSNNDELCFQKGDVITVTQREDGGWWEGTLNDKTGWFPSNYVNECKVQ----LPL 65
            :||:|:::|..:|.|||.|.|||:|.||:.|:|||||||.:.||||||||||.|.|..    .|.
 Frog   165 MVVRAKFNFQQTNEDELSFNKGDLIHVTRLEEGGWWEGTHSGKTGWFPSNYVREVKSSEKPVSPK 229

  Fly    66 TETIR-PPEEI------QEYRSVVLKDLLDSERAHVAELQGLLENFLEPMQQTQILSQDEYAQLM 123
            :.|:: ||:..      :.|.:|||:::||:|..:..|||.:|.|:|..:|.::.||....:.|:
 Frog   230 STTLKSPPKGFDTSAINKSYYNVVLQNILDTEGEYSKELQDILSNYLRHLQTSEKLSPTNISYLL 294

  Fly   124 CNFVEIVRTHEDLLIQIEEC------NDRVGKLFLTSAPLMKKVHQAYCAAHPKAIVILDKYKDE 182
            .|..||....:.|:..:|||      ..|||..|::..|.||.::.||||.||.|:.:|.::.:|
 Frog   295 GNLEEICAFQQILVQSLEECTKLPEGQQRVGGCFMSLMPQMKSLYIAYCANHPSAVNVLTQHSEE 359

  Fly   183 LEKYMERQGAATPGLLVLTTGLSKPFRRLDKYSAMLQELERHMESSHPDRGDTQRSVAVYKDIAA 247
            |.::||.:||.:||:|||||||||||.|||||..:|:|||||||..||||.|.|:|:..:|:::|
 Frog   360 LGEFMEMKGANSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHPDRPDIQKSMTAFKNLSA 424

  Fly   248 TCSATRRQKELELQVLTGPVRGWQGQELSTLGDIIHMGSVAV---GADHR-DRYFVLFPQTLLFL 308
            .|...|::||||||:||..:|||:|:::.|||.:|:|..|.:   |::.: :||.:|||..||.|
 Frog   425 QCQEVRKRKELELQILTETIRGWEGEDIKTLGTVIYMSQVMIQCAGSEEKNERYLLLFPNVLLML 489

  Fly   309 SVSQRMSAFIYEGKLPLTGIIVNRLEDTDALKNAFEISSPLIDRIVAVCQGPNEANKWVELLNAN 373
            |.|.|||.|||:||:||||:.|.:|||.:..|||:||:..:|:||:..|....:..:||:.|:.
 Frog   490 SASPRMSGFIYQGKIPLTGMCVTKLEDNENHKNAYEIAGNMIERIIVSCNNQQDLQEWVDYLHK- 553

  Fly   374 NPSLPMGIKRQLSNLSNSSLGHLNAAHLSQHLDSRGYCTRFSLCAYYSSPPCHVRPLRVTLPPSN 438
                    :.:.::|.|.:        :..|                 |.|||..|.....|.|.
 Frog   554 --------QTKYTSLINPT--------IKPH-----------------SVPCHTLPSHPVTPSSK 585

  Fly   439 Y------PATAPY---ANLSAHFARLVKGGGLRSAIVKMLLYPQARQ---SIDLKRIA--LRKRR 489
            :      |.|..|   .:||.|       |...|.|....|.|....   |:...|.|  ||...
 Frog   586 HSDCKLMPLTPAYHTLPHLSHH-------GTPHSTISWSPLEPPKTPKPWSLSCLRPAPPLRPSA 643

  Fly   490 --CHKASAKLKDLNTNQDSGQSELERQDAIELPTDSE----SYDDDFEDDFLHSCDSDPFEYVQF 548
              |:|     :||:.:..:.:..|.::.....|:|.|    ......|:      |:...:.::.
 Frog   644 ALCYK-----EDLSKSPKTMKKLLPKRKPERKPSDEEFALRKSTAALEE------DAQILKVIEA 697

  Fly   549 Y-QNKRNDSMCNST--GTFVDHGTGARRHCSSINLIKLDSADTDEVLALNELKKESLVIGSRALR 610
            | .:.:.....|||  ||.:.|     .|.         .||.|:                .:|.
 Frog   698 YCTSAKTRQTLNSTWQGTDLMH-----NHV---------LADDDQ----------------SSLD 732

  Fly   611 ALARKSTTRNSSVHTSTATLELGVGGSITNCVEEEPILKVKPSFSLQQQSSDASSIFAA---RLG 672
            :|.|:|:                             :.:::||.  ..:.||..||:.|   |:|
 Frog   733 SLGRRSS-----------------------------LSRLEPSD--LSEDSDYDSIWTAHSYRMG 766

  Fly   673 GAFTACENLASMPDDLSRESS---IQEPPTPLPASPTERHSMPTIFVGNRFNHSKNTEVYVPTWR 734
            .. :.|.. .|.|..|..|..   ::|..:.......|:..:.|::.
 Frog   767 ST-SRCRK-GSTPQVLLPEEEKIIVEETRSNGQTVIEEKSLVDTVYA------------------ 811

  Fly   735 DRQEMQNQSVDAKQDEELHSSSIDLPAACLSAPDKLQAELLYNYDE 780
                ::::..:.|||.:....|::.........:||..::|.|.::
 Frog   812 ----LKDEVQELKQDSKKMKKSLEEEQRARKELEKLIRKVLKNMND 853

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RtGEF	NP_001097184.2	SH3_PIX	6..58	CDD:212810	33/51 (65%)
		RhoGEF	79..249	CDD:238091	79/175 (45%)
		PH_Cool_Pix	281..376	CDD:269932	42/98 (43%)
arhgef7	XP_012813343.1	CH_betaPIX	3..114	CDD:409115
		RhoGEF67_u1	116..162	CDD:465201
		SH3_betaPIX	166..219	CDD:212994	33/52 (63%)
		RhoGEF	250..427	CDD:238091	79/176 (45%)
		PH_Cool_Pix	458..556	CDD:269932	42/106 (40%)
		RhoGEF67_u2	615..706	CDD:465200	18/101 (18%)
		betaPIX_CC	777..860	CDD:465158	14/99 (14%)