DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment La and LHP1

DIOPT Version :9

Sequence 1:	NP_477014.1	Gene:	La / 35305	FlyBaseID:	FBgn0011638	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	NP_010232.1	Gene:	LHP1 / 851509	SGDID:	S000002209	Length:	275	Species:	Saccharomyces cerevisiae

Alignment Length:	255	Identity:	70/255 - (27%)
Similarity:	124/255 - (48%)	Gaps:	40/255 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 IRQVEYYFGDANLNRDKFLREQIGKNEDGWVPLSVLVTFKRLASLSTDLSEIVAALNKSEEGLVE 119
            ::|||:||.:.|...|:|||....|| |||||:|.:.||.|:... ..:.:::.||..||  ::|
Yeast    34 LKQVEFYFSEFNFPYDRFLRTTAEKN-DGWVPISTIATFNRMKKY-RPVDKVIEALRSSE--ILE 94

  Fly   120 ISEDKLSLRRHPERPIPEHNEERRKEIQERTAYAKGFPLD----SQISELLD----FAANYDKVV 176
            :|.|..:::|.....:......|.:: .:||.....||.:    |||.||.:    |.....::.
Yeast    95 VSADGENVKRRVPLDLTAARNARIEQ-NQRTLAVMNFPHEDVEASQIPELQENLEAFFKKLGEIN 158

  Fly   177 NLTMRKHYDKPTKSYKFKGSIFLTFETKDQAKAFLE--------QEKIVYKEREL--LRKWQVDY 231
            .:.:|:.:    ::.||.|::.:.|:|..:.:|||:        .|.:.|:.::|  |.|.|.|.
Yeast   159 QVRLRRDH----RNKKFNGTVLVEFKTIPECEAFLKSYSNDDESNEILSYEGKKLSVLTKKQFDL 219

  Fly   232 LKE--KQEEYAQKNEKRKNKKEAKPEPAFELPKNAIVVFEGAPETSSREEIREAFEKIKD 289
            .:|  |.:.::.::......|: |..|.|  |||        .:.:.:||.:|....|.|
Yeast   220 QREASKSKNFSGRSRSFNGHKK-KNLPKF--PKN--------KKKNGKEESKEDSSAIAD 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
La	NP_477014.1	LARP_3	47..129	CDD:153397	28/73 (38%)
		RRM1_La	150..226	CDD:240737	22/93 (24%)
		RRM_SF	263..338	CDD:302621	6/27 (22%)
LHP1	NP_010232.1	LHP1	1..>244	CDD:227520	60/219 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345368
Domainoid	1	1.000	48	1.000	Domainoid score	I2987
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2962
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002882
OrthoInspector	1	1.000	-	-		otm46772
orthoMCL	1	0.900	-	-		OOG6_102594
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R649
SonicParanoid	1	1.000	-	-		X1665
TreeFam	0	0.000	Not matched by this tool.
	10	9.720