DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment La and Ssb

DIOPT Version :9

Sequence 1:	NP_477014.1	Gene:	La / 35305	FlyBaseID:	FBgn0011638	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	NP_112381.2	Gene:	Ssb / 81783	RGDID:	620804	Length:	415	Species:	Rattus norvegicus

Alignment Length:	418	Identity:	134/418 - (32%)
Similarity:	206/418 - (49%)	Gaps:	82/418 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 AKNGDAKKDPAPAAEEAAGGFTKQERAIIRQVEYYFGDANLNRDKFLREQIGKNEDGWVPLSVLV 91
            |:|||.:|   .||.||         .|..|:||||||.||.|||||:||| |.::|||||..::
  Rat     2 AENGDNEK---MAALEA---------KICHQIEYYFGDFNLPRDKFLKEQI-KLDEGWVPLETMI 53

  Fly    92 TFKRLASLSTDLSEIVAALNKSEEGLVEISEDKLSLRRHPERPIPEHNEERRKEIQERTAYAKGF 156
            .|.||..|:||.:.||.||:||:..|:|:|.||..:||.|.||:||..:|.:.:::.|:.|.|||
  Rat    54 KFNRLNRLTTDFNVIVQALSKSKANLMEVSADKTKIRRSPSRPLPEVTDEYKNDVKNRSVYIKGF 118

  Fly   157 PLDSQISELLDFAANYDKVVNLTMRKHYDKPTKSYKFKGSIFLTFETKDQAKAFLEQEKIVYKER 221
            |.|:.:.::.::..:..:::|:.||:...|     .||||||..|::...||.|::.....||:.
  Rat   119 PTDATLDDIKEWLDDKGQILNIQMRRTLHK-----TFKGSIFAVFDSIQSAKKFVDTPGQKYKDT 178

  Fly   222 ELLRKWQVDYLKEKQEEYAQKNE----KRKNKKEAKPEP------AFELPKNAIVVFEG-APETS 275
            .||..::.||..:|.||..|...    |.|.:.|.:.:|      |.|.....::.|.| ..:.:
  Rat   179 NLLILFKEDYFAKKNEERKQSKVEAKLKAKQEHEGRHKPGSTETRALEGKMGCLLKFSGDLDDQT 243

  Fly   276 SREEIREAFEKIKDFEVAYIEFAKGETKGSVRLTE--ADAAEKYIA---------------KVEE 323
            .||::...|.  ...|:.:|:|.:|..:|.:...|  .||.||..:               ||.|
  Rat   244 CREDLHFLFS--NHGEIKWIDFVRGAKEGIILFKEKAKDALEKARSANNGNLLLRNKKVTWKVLE 306

  Fly   324 GKLKFKDEVSLSLRKATEEEEKEFIDK--------------AIEFMKKRRDFTRNKGKR------ 368
            |..: ||    :::|.|:::: |.::|              :..|...||...|.||.|
  Rat   307 GHAE-KD----AMKKITDDQQ-ESLNKWKSKGGHAARRFKGSHVFTAARRFKGRGKGNRPAYAGA 365

  Fly   369 --------FNRKRHGGNDHKHGGGKKAR 388
                    ..|.|...:||:.|..|:.|
  Rat   366 PKGRGQFQGRRTRFDDDDHRRGPVKRGR 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
La	NP_477014.1	LARP_3	47..129	CDD:153397	41/81 (51%)
		RRM1_La	150..226	CDD:240737	24/75 (32%)
		RRM_SF	263..338	CDD:302621	21/92 (23%)
Ssb	NP_112381.2	LARP_3	10..91	CDD:153397	45/90 (50%)
		RRM1_La	112..183	CDD:240737	24/75 (32%)
		RRM_3	230..333	CDD:285930	25/110 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	323..415		16/71 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349379
Domainoid	1	1.000	70	1.000	Domainoid score	I9328
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2366
Inparanoid	1	1.050	176	1.000	Inparanoid score	I3945
OMA	1	1.010	-	-		QHG54025
OrthoDB	1	1.010	-	-		D400042at33208
OrthoFinder	1	1.000	-	-		FOG0002882
OrthoInspector	1	1.000	-	-		otm45327
orthoMCL	1	0.900	-	-		OOG6_102594
Panther	1	1.100	-	-	LDO	PTHR22792
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1665
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910