DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment La and Larp7

DIOPT Version :9

Sequence 1:	NP_477014.1	Gene:	La / 35305	FlyBaseID:	FBgn0011638	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	XP_038959070.1	Gene:	Larp7 / 686883	RGDID:	1592474	Length:	578	Species:	Rattus norvegicus

Alignment Length:	425	Identity:	121/425 - (28%)
Similarity:	193/425 - (45%)	Gaps:	97/425 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EVAETPSVEAQEEVAQPAEAQVLEAKNGDAKKDPAPAAEEAAGGFTKQERAIIRQVEYYFGDANL 67
            ||......|.|:.:.:..|      |..:.||..:...:..|.        |.:||:::||||||
  Rat     2 EVLRKMETENQKTMEESTE------KRKEEKKKRSRVKQVLAD--------IAKQVDFWFGDANL 52

  Fly    68 NRDKFLREQIGKNEDGWVPLSVLVTFKRLASLSTDLSEIVAALNKSEEGLVEISEDKLSLRRHPE 132
            ::|:||||||.|:.||:|.:|:||:|.::..|:||...|..||..|  .:||:..:...:||  :
  Rat    53 HKDRFLREQIEKSRDGYVDISLLVSFNKMKKLTTDGKLIARALKSS--SVVELDLEGTRIRR--K 113

  Fly   133 RPIPEHNEERRKEIQERTAYAKGFPLD---SQISELLDFAANYDKVVNLTMRKHYDKPTKSYKFK 194
            :|:    .||.|:.:|||.|.:..|.:   |.|..:.....|   ||.::: .|| |.|...  |
  Rat   114 KPL----GERPKDEEERTVYVELLPKNVTHSWIERVFGKCGN---VVYISI-PHY-KSTGDP--K 167

  Fly   195 GSIFLTFETKDQAKAFLE-----QEKIVYKE---RELLRKWQVDYLKEKQEEYAQKNEKRKNKKE 251
            |..|:.||||:||...:|     .|:...|.   .:.::...:..|:..:|:..:|.:|.:.|||
  Rat   168 GFAFVEFETKEQAAKAIEFLNNPPEEAPRKPGIFPKTVKNKPIPSLRVAEEKKKKKKKKGRIKKE 232

  Fly   252 AKPE--------------PAFELPKNAIVVFEGAPETSSREEIREAFEKIKDFEVAYIEFAKGET 302
            ...:              .|.:.|:.|   .||: |..:.|..::..:|.|..:       |.||
  Rat   233 ESVQAKELVVDSSSSGVSKATKRPRTA---SEGS-EAETPEAPKQPAKKKKKRD-------KVET 286

  Fly   303 KGSVRLTEADAAEKYIAKVEE-------GKLKFK----------DEVS---LSLRKATEEEEKEF 347
            .|   |.|:.|.::..:..|:       .|||.:          .|||   ..|...:.|||||.
  Rat   287 GG---LPESKAGKRERSSAEDEDCLPPRPKLKKRAQKDGGGPAASEVSKEHRDLEFCSTEEEKEP 348

  Fly   348 IDKAIEFMKKRRDFTRNKGKRFNRKRHGGNDHKHG 382
            .|        |:..:.:||||.::|:| ...||.|
  Rat   349 GD--------RKGDSLSKGKRKHKKKH-KERHKMG 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
La	NP_477014.1	LARP_3	47..129	CDD:153397	33/81 (41%)
		RRM1_La	150..226	CDD:240737	24/86 (28%)
		RRM_SF	263..338	CDD:302621	22/94 (23%)
Larp7	XP_038959070.1	LARP_7	32..112	CDD:153401	34/89 (38%)
		RRM1_LARP7	127..206	CDD:409732	24/85 (28%)
		RRM2_LARP7	450..531	CDD:409958
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910