DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment La and ssb

DIOPT Version :9

Sequence 1:	NP_477014.1	Gene:	La / 35305	FlyBaseID:	FBgn0011638	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	NP_001001455.1	Gene:	ssb / 407847	XenbaseID:	XB-GENE-491374	Length:	426	Species:	Xenopus tropicalis

Alignment Length:	401	Identity:	134/401 - (33%)
Similarity:	205/401 - (51%)	Gaps:	74/401 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 AKNGDAKKDPAPAAEEAAGGFTKQERAIIRQVEYYFGDANLNRDKFLREQIGKNEDGWVPLSVLV 91
            |:|||        .|:.....||    |..||||||||.||.|||||.:|| ..:||||||..::
Frog     2 AENGD--------KEQKLDLDTK----ICEQVEYYFGDHNLPRDKFLNQQI-LLDDGWVPLETMI 53

  Fly    92 TFKRLASLSTDLSEIVAALNKSEEGLVEISEDKLSLRRHPERPIPEHNEERRKEIQERTAYAKGF 156
            .|.||:.|:.|.:.|:.||.:|:..|:||.|||..:||.|.:|:||.|:|.:..::.::.|.|||
Frog    54 KFNRLSKLTKDFNTILQALKQSKTELLEIDEDKCKIRRSPAKPLPELNDEYKNSLKNKSVYIKGF 118

  Fly   157 PLDSQISELLDFAANYDKVVNLTMRKHYDKPTKSYKFKGSIFLTFETKDQAKAFLEQEKIVYKER 221
            |..:.:.::.::..:...:.|:.||:...|     :|||||||.|.|:|:||.|||.....|.:.
Frog   119 PTSANLDDIKEWLKDKGPIENIQMRRTLQK-----EFKGSIFLIFNTEDEAKKFLEDRNRKYNDS 178

  Fly   222 ELLRKWQVDYLKEKQEEYAQKNEKRK-NKKEAKP------EPAFELPKNA-----------IVVF 268
            :::       :..|:|.:|:||::|| ||.|.|.      |.|.:..::|           ::.|
Frog   179 DMI-------ILSKEEYFAKKNQERKLNKSEEKAKSKQENEEAQKQAEDAERKLMEERVGRLLKF 236

  Fly   269 EG-APETSSREEIREAFEKIKDFEVAYIEFAKGETKGSV--RLTEADAAEKYIAKVEEGKLKFKD 330
            .| ....:|||::...|:...|.|  :|:|::|..:|.|  ::....|.:|.:| .....||.|.
Frog   237 SGDLDNMTSREDLSALFQAHGDIE--WIDFSRGAKEGIVLFKMNAKKALDKAMA-ANNDDLKLKG 298

  Fly   331 EVSLSLRKATEEE------EKEFIDKAIEFMKKRRDFTRNK---GKRFNRKRHG--GNDHKHG-- 382
                   ||.:.|      |||.:.|.:|  .|:..|.:.|   |::|..|..|  |||....
Frog   299 -------KAVKWELIEGDAEKEALKKIME--DKQESFNKRKGRDGRKFKGKGRGGKGNDSSQRKR 354

  Fly   383 ---GGKKARGD 390
               .|||.:.|
Frog   355 IQFQGKKKKFD 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
La	NP_477014.1	LARP_3	47..129	CDD:153397	41/81 (51%)
		RRM1_La	150..226	CDD:240737	25/75 (33%)
		RRM_SF	263..338	CDD:302621	20/88 (23%)
ssb	NP_001001455.1	LARP_3	12..91	CDD:153397	41/83 (49%)
		RRM1_La	112..183	CDD:240737	25/82 (30%)
		RRM2_La	231..307	CDD:240985	22/85 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	65	1.000	Domainoid score	I9899
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2366
Inparanoid	1	1.050	176	1.000	Inparanoid score	I3935
OMA	1	1.010	-	-		QHG54025
OrthoDB	1	1.010	-	-		D400042at33208
OrthoFinder	1	1.000	-	-		FOG0002882
OrthoInspector	1	1.000	-	-		oto103544
Panther	1	1.100	-	-	LDO	PTHR22792
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1665
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080