DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment La and ssb

DIOPT Version :9

Sequence 1:	NP_477014.1	Gene:	La / 35305	FlyBaseID:	FBgn0011638	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	NP_955841.1	Gene:	ssb / 321504	ZFINID:	ZDB-GENE-030131-223	Length:	401	Species:	Danio rerio

Alignment Length:	367	Identity:	127/367 - (34%)
Similarity:	206/367 - (56%)	Gaps:	41/367 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 ERAIIRQVEYYFGDANLNRDKFLREQIGKNEDGWVPLSVLVTFKRLASLSTDLSEIVAALNKSEE 115
            |:.:..|:||||||.||.|||||:||: :.:||||||..::.|.||.||:::.|.||.:|.||:.
Zfish    11 EKKVAEQIEYYFGDHNLPRDKFLKEQL-QLDDGWVPLETMLKFNRLKSLTSEESVIVESLLKSKT 74

  Fly   116 GLVEISEDKLSLRRHPERPIPEHNEERRKEIQERTAYAKGFPLDSQISELLDFAANYDKVVNLTM 180
            ||:||||||..:||.|.:|:||:|||.|..::.::.|.|||||::.:.::.::.|:.....|:.:
Zfish    75 GLLEISEDKTKIRRDPNKPLPENNEEYRDALKHKSIYMKGFPLETTLDDVKEWLADKGTFENIYL 139

  Fly   181 RKHYDKPTKSYKFKGSIFLTFETKDQAKAFLEQEKIV-YKERELLRKWQVDYLKEKQEEYAQ--- 241
            ||   .|.|:  ||||||...||::.||||:|::.|. :|..|::...:..|..:|..|..|
Zfish   140 RK---GPQKT--FKGSIFAVLETEEAAKAFVERDDIKNFKGNEMIVMMKDAYFTKKIAERKQNRV 199

  Fly   242 ------KNEKRKNKKEAKPEPAFEL--PKNAIVVFEGAPETSSREEIREAFEKIKDFEVAYIEFA 298
                  |.:|.:.:|:|:.|....|  .:..::.|.|....:|||:....|.  ...::.:|:|.
Zfish   200 ESKAKAKCDKEEKQKQAEEEEMKSLNEQRGCLLKFSGELGQTSREDFHSVFS--DHAQIKWIDFT 262

  Fly   299 KGETKGSVRLTEADAAEKYIAKV------EEGKLK--------FKDEVSLSLRKATEEEEKEFID 349
            :|..:|:: |..::|.|. :.||      |:.|:|        .:.:|.:...|...|:::|.|:
Zfish   263 RGAKEGTI-LFHSNAKEA-LQKVREALNGEDPKVKEQAVQWEILEGDVEMETLKKIIEDQQESIN 325

  Fly   350 KAIEFMKKRRDFTRNKGK-RFNRKRHGGNDHKHGGGKKARGD 390
            |    .|..|...|.:|: |..|:..||.:|....|||.:.|
Zfish   326 K----RKGGRGGFRGRGRGRGGRRDRGGREHTQFKGKKTKFD 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
La	NP_477014.1	LARP_3	47..129	CDD:153397	42/77 (55%)
		RRM1_La	150..226	CDD:240737	28/76 (37%)
		RRM_SF	263..338	CDD:302621	19/88 (22%)
ssb	NP_955841.1	LARP_3	7..88	CDD:153397	42/77 (55%)
		RRM1_La	109..181	CDD:240737	28/76 (37%)
		RRM_3	229..326	CDD:285930	23/100 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590656
Domainoid	1	1.000	65	1.000	Domainoid score	I10070
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2366
Inparanoid	1	1.050	186	1.000	Inparanoid score	I3921
OMA	1	1.010	-	-		QHG54025
OrthoDB	1	1.010	-	-		D400042at33208
OrthoFinder	1	1.000	-	-		FOG0002882
OrthoInspector	1	1.000	-	-		oto39369
orthoMCL	1	0.900	-	-		OOG6_102594
Panther	1	1.100	-	-	LDO	PTHR22792
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R649
SonicParanoid	1	1.000	-	-		X1665
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.940