DRSC/TRiP Functional Genomics Resources

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Protein Alignment La and Larp4

DIOPT Version :10

Sequence 1:NP_477014.1 Gene:La / 35305 FlyBaseID:FBgn0011638 Length:390 Species:Drosophila melanogaster
Sequence 2:NP_001271452.1 Gene:Larp4 / 207214 MGIID:2443114 Length:720 Species:Mus musculus


Alignment Length:452 Identity:84/452 - (18%)
Similarity:163/452 - (36%) Gaps:139/452 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 EVAETPSVEAQE---EVAQPAEAQVLEAKNGDAKKDPAPAAEEAAGGFTKQE--RAIIRQVEYYF 62
            ||..:||.|...   :|.:.|:..:|..:  |........:.|::...:.::  ..:.:|:|:.|
Mouse    66 EVMYSPSCETTRNTADVEESADGMILGPE--DLSYQLYDVSGESSSAISTEDLKECLKKQLEFCF 128

  Fly    63 GDANLNRDKFLREQIGKNEDGWVPLSVLVTFKRLASLSTDLSEIVAALNKSEEGLVEISE--DKL 125
            ...||::|.:|..|:  :.|.:||:..:...:.:..|:|:...|:..|..|.  :|::.|  :|:
Mouse   129 SRENLSKDLYLISQM--DSDQFVPIWTVANMEEIKKLTTNTDLILEVLRSSP--MVQVDEKGEKV 189

  Fly   126 S---------LRRHPE-RPIPE-------------------HN-------------EERRKEIQE 148
            .         ||..|| .|:.|                   ||             ::..|.::|
Mouse   190 RPSHKRCIVILREIPETTPVEEVKALFKNENCPKVISCEFAHNSNWYITFQSDTDAQQAFKYLRE 254

  Fly   149 RTAYAKGFPLDSQISEL-LDFAANYDKVVNLTMRKHYDKPTKS-YKFKGSIFLTFETKDQAKAFL 211
            .....:|.|:.::|..: ..||.|..::::.:|   |.:|.:: .::...:|:       ...:.
Mouse   255 EVKTFQGKPIMARIKAINTFFAKNGYRLMDSSM---YTQPIQTPTQYPSPVFM-------QPVYN 309

  Fly   212 EQEKIVYKERELLRKWQVDYLKEKQEEYAQKNEKRKNKKEAKPEPAFELP--------------- 261
            .|:..||.  .:.:.|                       ...|.|.||.|               
Mouse   310 PQQYSVYS--LVPQSW-----------------------SPSPAPYFETPLAPFPNGSFVNGFSS 349

  Fly   262 -----KNAIVVFEGAPETSSREEIREAFEKIKDFEVAYIEFAKGETKGSVRLTEADAAEKYIAKV 321
                 .||..:..|.|...:|  ::..|......|        ..|:|||.|.:...:       
Mouse   350 PGSYKTNAAAMNMGRPFPKNR--VKPHFRSSSGSE--------HSTEGSVSLGDGPLS------- 397

  Fly   322 EEGKLKFKDEVSLSLR---KATEEEEKEFIDK--AIEFMKKRRDFTRNKGKRFNRKRHGGND 378
                 :....:.||.|   ..|.::|:.::.|  .|..|::..||.|.:...|..:|...:|
Mouse   398 -----RSSSRIFLSERHNPTVTGQQEQTYLPKEAPILQMEQNGDFGRGRRTLFRGRRRRDDD 454

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LaNP_477014.1 LARP_3 47..129 CDD:153397 20/94 (21%)
RRM1_La 150..226 CDD:409733 13/77 (17%)
RRM2_La 263..338 CDD:409957 15/77 (19%)
Larp4NP_001271452.1 Interaction with PABPC1. /evidence=ECO:0000250|UniProtKB:Q71RC2 13..22
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 22..56
Interaction with the poly-A tract of mRNA. /evidence=ECO:0000250|UniProtKB:Q71RC2 108..300 38/198 (19%)
LARP_4 117..191 CDD:153404 19/77 (25%)
RRM_LARP4 196..272 CDD:410106 13/75 (17%)
PHA03247 <320..717 CDD:223021 32/180 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 364..399 9/56 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 438..471 4/17 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 530..563
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 577..602
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 616..720
Blue background indicates that the domain is not in the aligned region.

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