DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment La and ssb-1

DIOPT Version :9

Sequence 1:	NP_477014.1	Gene:	La / 35305	FlyBaseID:	FBgn0011638	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	NP_491411.1	Gene:	ssb-1 / 172070	WormBaseID:	WBGene00016653	Length:	396	Species:	Caenorhabditis elegans

Alignment Length:	369	Identity:	123/369 - (33%)
Similarity:	201/369 - (54%)	Gaps:	32/369 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 EEAAGGFTKQERAIIRQVEYYFGDANLNRDKFLREQIGKNEDGWVPLSVLVTFKRLASLSTDLSE 105
            |.||......::.||:|:|||||:.||.|||||:|:: |.:|||||::.::.|.||||:|.|..:
Worm     3 ETAAAVHDDADQKIIKQLEYYFGNINLPRDKFLQEKL-KEDDGWVPITTMLNFNRLASISKDTEK 66

  Fly   106 IVAALNKSEEGLVEISEDKLSLRRHPERPIPEHNEERRKEIQERTAYAKGFPLDSQISELLDFAA 170
            |..|:..|..|::.:|||...:||:.|.|:||::.|..::|:.||.|.|||..|:|:.:::.:|.
Worm    67 IANAVKNSGSGIISVSEDNQKIRRNEENPVPENSLEYWQKIKHRTVYMKGFSTDTQLDDIIQWAN 131

  Fly   171 NYDKVVNLTMRKHYDKPTKSYKFKGSIFLTFETKDQAKAFLEQEKIVYKERELLRKWQVDY--LK 233
            .:.:..|:.||:.  || ....||||:|:|::|:::|:| .::.::.:.|.||.:..|.:|  ||
Worm   132 QFGETENVLMRRL--KP-GDRTFKGSVFITYKTREEAEA-AQKAEVKFGETELTKMMQDEYWTLK 192

  Fly   234 EKQEEYAQKNEK----RKNKKEA----KPEPAFELPKNAIVVFEGAPETSSREEIREAFEKIKDF 290
            .|:.:.|:...|    .||..||    |.:.|....|..|:..:|....|:.:.|: .|.|:..
Worm   193 NKETKEARAANKAAKSAKNTSEAIESEKAQHAVRYEKGLILAVDGLGPDSTIDSIK-TFFKLHG- 255

  Fly   291 EVAYIEFAKGETKGSVRL-TEADAAEK----YIAKVEEGKLKFKDEVSLSLRKATEEEEKEFIDK 350
            .|.|:....|.....:|. .:::.|:|    .:|...:||: ...|..||.|....|||:::
Worm   256 SVGYVAHENGGKTAEIRFNNDSEGAQKAWDNAVAAGTDGKV-ILQEAELSARVLDGEEEEKY--- 316

  Fly   351 AIEFMKKRRDFTRNKGKRFNRKRHGGNDHKHG----GGKKARGD 390
            ..||..::..  |..|.|..|...||...:.|    ||:..|||
Worm   317 WTEFNARKNQ--RQGGGRGGRGGRGGRGGRGGRGGRGGRGGRGD 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
La	NP_477014.1	LARP_3	47..129	CDD:153397	36/81 (44%)
		RRM1_La	150..226	CDD:240737	25/75 (33%)
		RRM_SF	263..338	CDD:302621	18/79 (23%)
ssb-1	NP_491411.1	LARP_3	9..90	CDD:153397	36/81 (44%)
		RRM1_La	111..183	CDD:240737	25/75 (33%)
		RRM_3	230..328	CDD:285930	24/105 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164076
Domainoid	1	1.000	69	1.000	Domainoid score	I6315
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2366
Inparanoid	1	1.050	175	1.000	Inparanoid score	I2705
Isobase	1	0.950	-	0	Normalized mean entropy	S2962
OMA	1	1.010	-	-		QHG54025
OrthoDB	1	1.010	-	-		D400042at33208
OrthoFinder	1	1.000	-	-		FOG0002882
OrthoInspector	1	1.000	-	-		oto17622
orthoMCL	1	0.900	-	-		OOG6_102594
Panther	1	1.100	-	-	LDO	PTHR22792
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R649
SonicParanoid	1	1.000	-	-		X1665
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.890