DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pyroxd1 and AIFM1

DIOPT Version :9

Sequence 1:	NP_001260619.1	Gene:	Pyroxd1 / 35296	FlyBaseID:	FBgn0032846	Length:	472	Species:	Drosophila melanogaster
Sequence 2:	NP_004199.1	Gene:	AIFM1 / 9131	HGNCID:	8768	Length:	613	Species:	Homo sapiens

Alignment Length:	452	Identity:	96/452 - (21%)
Similarity:	175/452 - (38%)	Gaps:	127/452 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FLVVGGGIAGVSCAESLAIYRPNASILLLTES--------SIVKSV-----TNLVPVARYLHKFD 58
            ||::|||.|..:.|.|:....|.|.:|:::|.        .:.|.:     .|:....|: .:::
Human   134 FLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVTKTLRF-KQWN 197

  Fly    59 VREQDVSEMGASFQTLVDRLDHINS----------------REHCIRTKAGLEIKYRYLCLCTGG 107
            .:|:.:.....||......|.||.:                |::.::...|.:|.|....:.|||
Human   198 GKERSIYFQPPSFYVSAQDLPHIENGGVAVLTGKKVVQLDVRDNMVKLNDGSQITYEKCLIATGG 262

  Fly   108 TPKLFSG--------KVVNPLVIGIRDTDSVQLLQRKLATAKDVLILGNGGIASELAYELKDVNV 164
            ||:..|.        |....|...|.|..|::.:.|::   |.:.|:|.|.:.||||..|.
Human   263 TPRSLSAIDRAGAEVKSRTTLFRKIGDFRSLEKISREV---KSITIIGGGFLGSELACALG---- 320

  Fly   165 HWVVKDSHISATFVDPGAAEFFHIAMNECNAKDSSPVVAIKRMRYSEVLPKEQTNNHGAALGPDW 229
                                      .:..|..:..:         ::.|::  .|.|..| |::
Human   321 --------------------------RKARALGTEVI---------QLFPEK--GNMGKIL-PEY 347

  Fly   230 HRSVDLSGAREGEENRLPKIYYKSRISSVQDLADDAG-AIVKLEHEDGSFQQLTCDFIVSATGVW 293
            ..:..:...|......:|.       :.||.:...:| .::||  :||  :::..|.||:|.|:.
Human   348 LSNWTMEKVRREGVKVMPN-------AIVQSVGVSSGKLLIKL--KDG--RKVETDHIVAAVGLE 401

  Fly   294 PNTDYTCDSPLQF-SDDGGISVDEMM--RTNLVDVFAAGDVCTANWPAAMHWFQMRLWTQ----- 350
            ||.:......|:. ||.||..|:..:  |:|   ::.|||        |..::.::|..:
Human   402 PNVELAKTGGLEIDSDFGGFRVNAELQARSN---IWVAGD--------AACFYDIKLGRRRVEHH 455

  Fly   351 --ARQMGSMAGRSMAAASE---GESVY-----QDFCFELFGHVTKLFGYPVV-LLGRFNGQD 401
              |...|.:||.:|..|::   .:|::     .|..:|..|.|..  ..|.| :..:...||
Human   456 DHAVVSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDS--SLPTVGVFAKATAQD 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pyroxd1	NP_001260619.1	Pyr_redox_2	8..355	CDD:285266	81/394 (21%)
AIFM1	NP_004199.1	Mitochondrial localization signal. /evidence=ECO:0000250\|UniProtKB:Q9Z0X1	1..31
		AIF-MLS	52..>133	CDD:317386
		Mitochondrial localization signal. /evidence=ECO:0000250\|UniProtKB:Q9Z0X1	63..89
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..127
		FAD-dependent oxidoreductase. /evidence=ECO:0000250	134..483		88/416 (21%)
		Pyr_redox_2	150..462	CDD:311792	74/379 (20%)
		Nuclear localization signal. /evidence=ECO:0000255	446..451		1/4 (25%)
		AIF_C	465..593	CDD:317164	13/53 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..554		2/3 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0446
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810