DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pyroxd1 and PYROXD1

DIOPT Version :9

Sequence 1:	NP_001260619.1	Gene:	Pyroxd1 / 35296	FlyBaseID:	FBgn0032846	Length:	472	Species:	Drosophila melanogaster
Sequence 2:	NP_079130.2	Gene:	PYROXD1 / 79912	HGNCID:	26162	Length:	500	Species:	Homo sapiens

Alignment Length:	499	Identity:	232/499 - (46%)
Similarity:	316/499 - (63%)	Gaps:	42/499 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EFLVVGGGIAGVSCAESLAIYRPNASILLLTESSIVKSVTNLVPVARYLHKFDVREQDVSEMGAS 70
            :|:|||||||||:|||.||.:.|:..|||:|.|.::|:|||...:::.|.:|||.||..:.:|..
Human    12 KFVVVGGGIAGVTCAEQLATHFPSEDILLVTASPVIKAVTNFKQISKILEEFDVEEQSSTMLGKR 76

  Fly    71 F---QTLVDRLDHINSREHCIRTKAGLEIKYRYLCLCTGGTPKLF-SGKVVNPLVIGIRDTDSVQ 131
            |   :.:...:..:.|.||||.|:.|.:..|:.||||.|..|||. .|   ||.|:|||||||.|
Human    77 FPNIKVIESGVKQLKSEEHCIVTEDGNQHVYKKLCLCAGAKPKLICEG---NPYVLGIRDTDSAQ 138

  Fly   132 LLQRKLATAKDVLILGNGGIASELAYELKDVNVHWVVKDSHISATFVDPGAAEFFHIAMNECNAK 196
            ..|::|..||.::|:||||||.||.||::...|.|.:||..|..||.|.|||||.   .::..|:
Human   139 EFQKQLTKAKRIMIIGNGGIALELVYEIEGCEVIWAIKDKAIGNTFFDAGAAEFL---TSKLIAE 200

  Fly   197 DSSPVVAIKRMRYS------EVLPKEQTNNHGAALGPDWHRSVDLSGAREGEENRLPKIYYKSRI 255
            .|...:|.||.||:      |...|.:.:|.|:|||||||..::|.|.:|...    ||:.::..
Human   201 KSEAKIAHKRTRYTTEGRKKEARSKSKADNVGSALGPDWHEGLNLKGTKEFSH----KIHLETMC 261

  Fly   256 SSVQDLADDAGAIVK-------LEHEDGS--------FQQLT------CDFIVSATGVWPNTD-Y 298
            ...:....|...|:|       .:|:..:        :.:||      ||||||||||.||.: :
Human   262 EVKKIYLQDEFRILKKKSFTFPRDHKSVTADTEMWPVYVELTNEKIYGCDFIVSATGVTPNVEPF 326

  Fly   299 TCDSPLQFSDDGGISVDEMMRTNLVDVFAAGDVCTANWPAAMHWFQMRLWTQARQMGSMAGRSMA 363
            ...:.....:|||:.||:.|.|:|.|::||||:||.:|..:..|.||||||||||||..|.:.||
Human   327 LHGNSFDLGEDGGLKVDDHMHTSLPDIYAAGDICTTSWQLSPVWQQMRLWTQARQMGWYAAKCMA 391

  Fly   364 AASEGESVYQDFCFELFGHVTKLFGYPVVLLGRFNGQDLGRDYEILVRCTRNKEYIKFVLQNGRL 428
            |||.|:|:..||.||||.||||.|.|.|||||::|.|.||.|:|:::|||:.:||||.|:||||:
Human   392 AASSGDSIDMDFSFELFAHVTKFFNYKVVLLGKYNAQGLGSDHELMLRCTKGREYIKVVMQNGRM 456

  Fly   429 RGAMLIGNTDLAETCENLILNGIDLEPYGDDILNPDIDIEDYFD 472
            .||:|||.|||.||.||||||.::|..||:|:|:|:||||||||
Human   457 MGAVLIGETDLEETFENLILNQMNLSSYGEDLLDPNIDIEDYFD 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pyroxd1	NP_001260619.1	Pyr_redox_2	8..355	CDD:285266	156/378 (41%)
PYROXD1	NP_079130.2	Pyr_redox_2	24..383	CDD:330998	147/368 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..235		6/23 (26%)
		NirB	<300..>494	CDD:330997	108/193 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147152
Domainoid	1	1.000	168	1.000	Domainoid score	I3845
eggNOG	1	0.900	-	-		E1_COG0446
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11758
Inparanoid	1	1.050	425	1.000	Inparanoid score	I1767
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55526
OrthoDB	1	1.010	-	-		D1463391at2759
OrthoFinder	1	1.000	-	-		FOG0006989
OrthoInspector	1	1.000	-	-		oto91708
orthoMCL	1	0.900	-	-		OOG6_106473
Panther	1	1.100	-	-	LDO	PTHR43429
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1984
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770