DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pyroxd1 and Aifm1

DIOPT Version :9

Sequence 1:	NP_001260619.1	Gene:	Pyroxd1 / 35296	FlyBaseID:	FBgn0032846	Length:	472	Species:	Drosophila melanogaster
Sequence 2:	NP_036149.1	Gene:	Aifm1 / 26926	MGIID:	1349419	Length:	612	Species:	Mus musculus

Alignment Length:	457	Identity:	94/457 - (20%)
Similarity:	169/457 - (36%)	Gaps:	137/457 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FLVVGGGIAGVSCAESLAIYRPNASILLLTES----------------SIVKSVTNLVPVARYLH 55
            ||::|||.|..:.|.|:....|.|.:|:::|.                |...:||..:...::..
Mouse   133 FLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVTKTLQFRQWNG 197

  Fly    56 K----------FDVREQDVS--EMGASFQTLVDRLDHINSREHCIRTKAGLEIKYRYLCLCTGGT 108
            |          |.|..||:.  |.|........::.|::.|.:.::...|.:|.:....:.||||
Mouse   198 KERSIYFQPPSFYVSAQDLPNIENGGVAVLTGKKVVHLDVRGNMVKLNDGSQITFEKCLIATGGT 262

  Fly   109 PKLFS-----GKVVNPLVIGIRDTDSVQLLQRKLATAKDVLILGNGGIASELAYELKDVNVHWVV 168
            |:..|     |..|.......|.....:.|::.....|.:.::|.|.:.||||
Mouse   263 PRSLSAIDRAGAEVKSRTTLFRKIGDFRALEKISREVKSITVIGGGFLGSELA------------ 315

  Fly   169 KDSHISATFVDPGAAEFFHIAMNECNAKDSSPVVAI--KRMRYSEVLPK-------EQTNNHGAA 224
                               .|:...:......|:.:  ::....::||:       |:....|..
Mouse   316 -------------------CALGRKSQASGIEVIQLFPEKGNMGKILPQYLSNWTMEKVKREGVK 361

  Fly   225 LGPD-WHRSVDLSGAREGEENRLPKIYYKSRISSVQDLADDAGAIVKLEHEDGSFQQLTCDFIVS 288
            :.|: ..:||.:||.|                           .::||  :||  :::..|.||:
Mouse   362 VMPNAIVQSVGVSGGR---------------------------LLIKL--KDG--RKVETDHIVT 395

  Fly   289 ATGVWPNTDYTCDSPLQF-SDDGGISVDEMM--RTNLVDVFAAGDVCTANWPAAMHWFQMRLWTQ 350
            |.|:.||.:......|:. ||.||..|:..:  |:|   ::.|||        |..::.::|..:
Mouse   396 AVGLEPNVELAKTGGLEIDSDFGGFRVNAELQARSN---IWVAGD--------AACFYDIKLGRR 449

  Fly   351 -------ARQMGSMAGRSMAAASE---GESVY-----QDFCFELFGHVTKLFGYPVV-LLGRFNG 399
                   |...|.:||.:|..|::   .:|::     .|..:|..|.|..  ..|.| :..:...
Mouse   450 RVEHHDHAVVSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDS--SLPTVGVFAKATA 512

  Fly   400 QD 401
            ||
Mouse   513 QD 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pyroxd1	NP_001260619.1	Pyr_redox_2	8..355	CDD:285266	79/399 (20%)
Aifm1	NP_036149.1	Mitochondrial localization signal. /evidence=ECO:0000305\|PubMed:9989411	1..30
		vWFA	<47..121	CDD:294047
		Mitochondrial localization signal. /evidence=ECO:0000305\|PubMed:9989411	62..88
		FAD-dependent oxidoreductase	133..482		86/421 (20%)
		Pyr_redox_2	149..446	CDD:285266	70/369 (19%)
		Pyr_redox	301..385	CDD:278498	20/143 (14%)
		Nuclear localization signal. /evidence=ECO:0000255	445..450		1/4 (25%)
		AIF_C	464..592	CDD:291391	13/53 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	512..551		2/3 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0446
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810