DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pyroxd1 and Pyroxd1

DIOPT Version :9

Sequence 1:	NP_001260619.1	Gene:	Pyroxd1 / 35296	FlyBaseID:	FBgn0032846	Length:	472	Species:	Drosophila melanogaster
Sequence 2:	NP_898988.2	Gene:	Pyroxd1 / 232491	MGIID:	2676395	Length:	498	Species:	Mus musculus

Alignment Length:	500	Identity:	233/500 - (46%)
Similarity:	313/500 - (62%)	Gaps:	45/500 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FLVVGGGIAGVSCAESLAIYRPNASILLLTESSIVKSVTNLVPVARYLHKFDVREQDVSEMGASF 71
            |:|||||||||:|||.||:..|...|||:|.|.::|:|||...|::.|.:|||.||..:.:.:.|
Mouse    10 FVVVGGGIAGVTCAEQLAVSFPEEDILLVTASPVIKAVTNFRQVSKVLEEFDVEEQPGTMLESRF 74

  Fly    72 ---QTLVDRLDHINSREHCIRTKAGLEIKYRYLCLCTGGTPKL-FSGKVVNPLVIGIRDTDSVQL 132
               :.:...:..:.|.:|||.|:.|.|..|:.||||.|..||| :.|   ||.|:|||||||.|.
Mouse    75 PNIKVIESGVKQLKSEDHCIFTEDGREFVYKKLCLCAGAKPKLIYEG---NPRVLGIRDTDSAQE 136

  Fly   133 LQRKLATAKDVLILGNGGIASELAYELKDVNVHWVVKDSHISATFVDPGAAEFFHIAMNECNAKD 197
            .|::||.|:.::|:||||||.|||||::...|.|.:||:.|..||.|.|||||.   .::..::.
Mouse   137 FQKELAKARRIMIVGNGGIALELAYEIEGCEVVWAIKDNAIGNTFFDAGAAEFL---TSKLMSEK 198

  Fly   198 SSPVVAIKRMRYS------EVLPKEQTNNHGAALGPDWHRSVDLSGAREGEEN-------RLPKI 249
            |...:|.||..|:      |...|.:.:..|:|||||||..:.|.|..|...:       .:.||
Mouse   199 SEAKIAHKRTIYTVEEAKKETRTKSKADYVGSALGPDWHGGLALKGTEEFSHSVHIETRCEVKKI 263

  Fly   250 YYKS--RISSVQDLADDAGAIVKLEHEDGS--------FQQLT------CDFIVSATGVWPNT-D 297
            |.:.  :|...:.|     |..|..|:..:        :.:||      |||:||||||.||. .
Mouse   264 YLEEEFKIMKKKSL-----AFPKDHHKSVTADKEMWPVYVELTNGTIYGCDFLVSATGVTPNVHP 323

  Fly   298 YTCDSPLQFSDDGGISVDEMMRTNLVDVFAAGDVCTANWPAAMHWFQMRLWTQARQMGSMAGRSM 362
            :...:.....:|||:.||:.|||:|.|::||||:|||.|..:..|.||||||||||||..|.:.|
Mouse   324 FLHRNNFALGEDGGLRVDDQMRTSLPDIYAAGDICTACWQPSPVWQQMRLWTQARQMGYYAAKCM 388

  Fly   363 AAASEGESVYQDFCFELFGHVTKLFGYPVVLLGRFNGQDLGRDYEILVRCTRNKEYIKFVLQNGR 427
            ||||.|..:..||.||||.||||.|.|.|||||::|.|.||.|:|:::||||.:||:|.|:||||
Mouse   389 AAASMGHPIDMDFSFELFAHVTKFFNYKVVLLGKYNAQGLGADHELMLRCTRGQEYVKVVMQNGR 453

  Fly   428 LRGAMLIGNTDLAETCENLILNGIDLEPYGDDILNPDIDIEDYFD 472
            :.||:|||.|||.||.||||||.:||..||:|:|:|:||||||||
Mouse   454 MMGAVLIGETDLEETFENLILNQMDLSSYGEDLLDPNIDIEDYFD 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pyroxd1	NP_001260619.1	Pyr_redox_2	8..355	CDD:285266	157/380 (41%)
Pyroxd1	NP_898988.2	Pyr_redox_2	<76..381	CDD:285266	136/335 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837096
Domainoid	1	1.000	168	1.000	Domainoid score	I3833
eggNOG	1	0.900	-	-		E1_COG0446
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11758
Inparanoid	1	1.050	416	1.000	Inparanoid score	I1808
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55526
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006989
OrthoInspector	1	1.000	-	-		oto95290
orthoMCL	1	0.900	-	-		OOG6_106473
Panther	1	1.100	-	-	LDO	PTHR43429
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3689
SonicParanoid	1	1.000	-	-		X1984
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790