DRSC/TRiP Functional Genomics Resources

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Protein Alignment neb and KIF3B

DIOPT Version :10

Sequence 1:NP_476817.1 Gene:neb / 35293 FlyBaseID:FBgn0004374 Length:1121 Species:Drosophila melanogaster
Sequence 2:NP_004789.1 Gene:KIF3B / 9371 HGNCID:6320 Length:747 Species:Homo sapiens


Alignment Length:945 Identity:253/945 - (26%)
Similarity:403/945 - (42%) Gaps:258/945 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   116 SEESNMIVAVRVRPLNALECTRGQVTNVVQVHGNSNELTVQAGSSADASAGVTH----FFSYDQV 176
            |.||..:| ||.||:|..| .......||.|.....:::|:      ...|..|    .|::|.|
Human     6 SSESVRVV-VRCRPMNGKE-KAASYDKVVDVDVKLGQVSVK------NPKGTAHEMPKTFTFDAV 62

  Fly   177 YYSCDPERKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGG 241
            |   |...|.|    ::::.|.|||:|:..:|:|..:|||||||:||:|:|.||.         |
Human    63 Y---DWNAKQF----ELYDETFRPLVDSVLQGFNGTIFAYGQTGTGKTYTMEGIR---------G 111

  Fly   242 PPHDEAGIIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQ 306
            .| ::.|:||.....:|..|...::||.|   |..||.|||.|:|.||||               
Human   112 DP-EKRGVIPNSFDHIFTHISRSQNQQYL---VRASYLEIYQEEIRDLLS--------------- 157

  Fly   307 QQQQQQRPALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIF 371
               :.|...|:::|.|..|.||.|||:....|...:.:.:.|||..|:..:|.||:.|||||:||
Human   158 ---KDQTKRLELKERPDTGVYVKDLSSFVTKSVKEIEHVMNVGNQNRSVGATNMNEHSSRSHAIF 219

  Fly   372 NIVLNLTDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINKS 436
            .|.:..:::    ||..:         ...|..|::|||||||||.:.:|:.|||::|...||.|
Human   220 VITIECSEV----GLDGE---------NHIRVGKLNLVDLAGSERQAKTGAQGERLKEATKINLS 271

  Fly   437 LLTLGKVIAALADSRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASIH 501
            |..||.||:||.|.:             ||.:|||:|.||.||:::||||:||||:|.:.|||.:
Human   272 LSALGNVISALVDGK-------------STHIPYRDSKLTRLLQDSLGGNAKTVMVANVGPASYN 323

  Fly   502 ADETLATLRYACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSL-------RNEYERQRRLSGN 559
            .:|||.|||||.:|::|.|:.:|||.|.|.::|:.:.|:.|||:.       |.:...:||..|.
Human   324 VEETLTTLRYANRAKNIKNKPRVNEDPKDALLREFQEEIARLKAQLEKRSIGRRKRREKRREGGG 388

  Fly   560 SNNPVPRKIIIETSVDETEVEALRQQLAERERELSRAQKSWMEKLKEAEDQRKSELRVLKRRGLA 624
            |..          ..:|.|.|.     .|.|.|.......|.|:      |.|.|:         
Human   389 SGG----------GGEEEEEEG-----EEGEEEGDDKDDYWREQ------QEKLEI--------- 423

  Fly   625 LELTAEQKQACLVNLTADPILSGTLFYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVALQHCS 689
                  :|:|                                         ||.|..|||.:...
Human   424 ------EKRA-----------------------------------------IVEDHSLVAEEKMR 441

  Fly   690 IEHERGGKLYVIPGSEDFETYVNGELLKDRRQLFHGDRLVIGGSHYFRISNPFCSQRGKADHPVD 754
            :..|:..|:..:...:|     ..|:|..:.:... .:|::||.:.                 ||
Human   442 LLKEKEKKMEDLRREKD-----AAEMLGAKIKAME-SKLLVGGKNI-----------------VD 483

  Fly   755 FQLAHQEILQKQEQQLRSELEAEKRAALTKIEQERAQHARDFEERLQCLELEQFKYKCNSEMLET 819
            .....|:||:::.|::     ||::....:|:|:  ..:|| ||.|              |:.||
Human   484 HTNEQQKILEQKRQEI-----AEQKRREREIQQQ--MESRD-EETL--------------ELKET 526

  Fly   820 ERQALALAQQQEHTPLRHEDAVSTPAQKSTI--LEDIQRIMLNPSEESLHKTQLMVKEATQRCRQ 882
                        ::.|:.|..:.|...|...  |:.::..:.:..||.:.:.|.:.:...:..|:
Human   527 ------------YSSLQQEVDIKTKKLKKLFSKLQAVKAEIHDLQEEHIKERQELEQTQNELTRE 579

  Fly   883 LDL---------PLEFRQ--------TQTPDEFGLLRTVILILDKQRGLKAEWPTARLGVWLDLV 930
            |.|         |||.:.        .:..|.:.|  ..|..|:.|:.:|.  |.:.:|....| 
Human   580 LKLKHLIIENFIPLEEKSKIMNRAFFDEEEDHWKL--HPITRLENQQMMKR--PVSAVGYKRPL- 639

  Fly   931 RDNAEQQEKLNATTIFQSVEVDWEPLDADLNETLSDTHNSSRIALNLSAMKDVLLNKPLKRLLNA 995
            ..:|.....:.....:::..:  ..|:.|:....:..:....||..:.|..|..|....:..::|
Human   640 SQHARMSMMIRPEARYRAENI--VLLELDMPSRTTRDYEGPAIAPKVQAALDAALQDEDEIQVDA 702

  Fly   996 SSSKSNTPRQ---------------TSTPSPGSQL 1015
            ||.:|...::               :|:.:|.|||
Human   703 SSFESTANKKSKARPKSGRKSGSSSSSSGTPASQL 737

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nebNP_476817.1 KISc_KIF1A_KIF1B 119..525 CDD:276816 151/409 (37%)
SMC_N 514..>615 CDD:481474 28/107 (26%)
FHA_KIF14 627..741 CDD:438759 16/113 (14%)
KIF3BNP_004789.1 KISc_KIF3 8..340 CDD:276822 150/403 (37%)
Smc <355..>581 CDD:440809 64/359 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 374..412 11/52 (21%)
Globular 580..747 31/165 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 699..747 9/39 (23%)

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