Protein Alignment neb and KIP3

DIOPT Version :10

• Sequence 1: NP_476817.1
• Gene: neb / 35293
• FlyBaseID: FBgn0004374
• Length: 1121
• Species: Drosophila melanogaster
• Sequence 2: NP_011299.1
• Gene: KIP3 / 852655
• SGDID: S000003184
• Length: 805
• Species: Saccharomyces cerevisiae
• Alignment Length: 995
• Identity: 230/995 - (23%)
• Similarity: 385/995 - (38%)
• Gaps: 302/995 - (30%)

  Fly    73 YTPSSLYRNANSTPG-RAKTPGTGKSSC-------------------SRTKERDSLME------- 110
            :|.....|..|...| .|..||.|.||.                   |...:|:||:.
Yeast    20 FTSMEKTRLVNEASGAEANFPGLGDSSLILPMSNNSDSDIDIDAEEGSTRSKRNSLLRRKVIRPE 84

  Fly   111 ------SCLSVSEESNMIV---AVRVRPLN-----ALECTRGQVTNVVQVHGNSNELTVQAGSSA 161
                  .|:    :..|::   |.| .|||     .|...|.:.|.......|::..|.:..|..
Yeast    85 GIRKIVDCV----DDRMLIFDPADR-NPLNKVSDQVLNSMRARATKATASSINNSNATNKFSSQR 144

  Fly   162 DASAGVTHFFSYDQVYYSCDPERKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYS 226
            ....|...|. :|:::       ...:.||:|::.|..||:|:..:|:|:.:||||.||.||:|:
Yeast   145 RRHGGEIKFV-FDKLF-------DETSSQARVYKETTSPLLDSVLDGFNSTVFAYGATGCGKTYT 201

  Fly   227 MMGIEALDDAALDGGPPHDEAGIIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLS 291
            :.|..:             :.|||.....|||.:|..:|.::..  |:.:||.|||||:|.|||.
Yeast   202 VSGTPS-------------QPGIIFLAMEELFNKITDLKDEKDF--EISLSYLEIYNERIRDLLK 251

  Fly   292 VQHAAAATGESTPIQQQQQQQRPALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATA 356
            .:         ||.::        |.:||.......|.:||.|..::...:.:.:..||..|.|:
Yeast   252 PE---------TPSKR--------LVIREDTQNHIKVANLSYHHPNTVEDVMDLVVQGNINRTTS 299

  Fly   357 STAMNDKSSRSHSIFNIVL----NLTDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERI 417
            .|..|:.|||||::..|.:    .|.||:|                 |...:.:|::|||||||.
Yeast   300 PTEANEVSSRSHAVLQIHIMQTNKLVDLTS-----------------QHTFATLSIIDLAGSERA 347

  Fly   418 SVSGSNGERIREGVSINKSLLTLGKVIAALADSRKAIANGPLGSGTPSTFVPYRESVLTWLLREN 482
            :.:.:.|.|:.||.:||:|||.||..|.||.          |..|:.|..:|||:|.||.||:.:
Yeast   348 AATRNRGIRLHEGANINRSLLALGNCINALC----------LNDGSRSCHIPYRDSKLTRLLKFS 402

  Fly   483 LGGNSKTVMLATISPASIHADETLATLRYACKARSIVNRVKVNE---SPHD----KIIRDLRAEV 540
            ||||.||||:..|||:|.|.||||.||:||.:|:.|..::..|:   |.|.    |:|.:.:.::
Yeast   403 LGGNCKTVMIVCISPSSSHYDETLNTLKYANRAKEIKTKIIRNQQSLSRHVGSYLKMITEQKRQI 467

  Fly   541 DRLKSLRNEYERQRRLSGNSNNPVPRKIIIETSVDETEVEALRQQLAERERELSRAQKSW--MEK 603
            :.|:      ||:.::             |...:.:.::...:.|||..|. ::|.|:::  :|.
Yeast   468 EELR------EREEKM-------------ISLKLTKYKLNKEKIQLAINEC-VNRVQQTYAGVET 512

  Fly   604 LKEAEDQRKSELRVLKRRGLALELTAEQKQACLVNLTADPILSGTLFYLLPQGLVRIGRGRLPGG 668
            .:.|:..:  .|.:.|||.|.           :|.|..|.::  .||            .|....
Yeast   513 YQVAKTLK--SLILCKRRFLQ-----------MVKLEVDNLI--LLF------------EREEST 550

  Fly   669 SSSSQPDIVLDGPLVALQHCSIEHERGGKLYVIPGSEDFETYVNGELLKDRRQLFHGDRLVIGGS 733
            ::..||         .:.:|.                                       :|.|.
Yeast   551 AAEMQP---------VISNCR---------------------------------------MISGQ 567

  Fly   734 HYFRISNPFCSQRGKADHPVDFQLAHQEILQKQEQQLRSELEAEKRAALTKIEQERAQHARDFEE 798
            .|.:|            |.::.:....:.|.....|:.|            |:..:.:...|::|
Yeast   568 LYNKI------------HELEMKFDETDTLSSVIHQVHS------------IDLNKLREMEDWDE 608

  Fly   799 RLQCLELEQFKYKCNSEMLETERQALALAQQQEHTPLRHEDAVSTPAQKS--------------- 848
            ....:.||    .|.:::.|.:|..:.:     ::.:..|..:|.|...|
Yeast   609 TYDLVYLE----SCLNQISELQRNEILV-----NSSIMTEKLMSDPGLNSRFKFLSKWLMNRTPN 664

  Fly   849 --TILEDIQRI-----------MLNPSEESLHKTQLMVKEATQRCRQLDLPLEFRQTQTPDEFGL 900
              :|::|:..|           :.|| :.:...|.:.:...|  ...|.:|.|..|.|...:
Yeast   665 IESIIQDLVHIDEEFESFARTFIANP-DSNFTNTNINIINTT--AADLAVPAETLQRQNFSQ--- 723

  Fly   901 LRTVILILDKQRGLKAEWPTARLGVWLDLVRDNAEQQEKLNATTIFQSVEVDWEPLDADLNETLS 965
                         .|.:|.:..|.. ..::....|.:.:|:......:.|||....|...||...
Yeast   724 -------------KKVKWTSPDLSP-SPMIEPQPELEPELHQDQDAIASEVDVSMQDTTFNEQGP 774

  Fly   966 DTHNSSRIALNLSAMKDVLL 985
            .|.::...|:....|:..||
Yeast   775 STPSAPTTAVPRRKMRSSLL 794

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	136/417 (33%)
		SMC_N	514..>615	CDD:481474	19/109 (17%)
		FHA_KIF14	627..741	CDD:438759	13/113 (12%)
KIP3	NP_011299.1	KISc_KIP3_like	82..438	CDD:276821	136/427 (32%)