DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment neb and Kif3c

DIOPT Version :9

Sequence 1:	NP_476817.1	Gene:	neb / 35293	FlyBaseID:	FBgn0004374	Length:	1121	Species:	Drosophila melanogaster
Sequence 2:	NP_445938.1	Gene:	Kif3c / 85248	RGDID:	621538	Length:	796	Species:	Rattus norvegicus

Alignment Length:	826	Identity:	230/826 - (27%)
Similarity:	356/826 - (43%)	Gaps:	230/826 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 SRTKERDSLMESCLSVSEESNMIVAVRVRPLNALECTRGQVTNVVQVHGNSNELTVQAGSSADAS 164
            |:||..::|.             |..|.|||:..|...|. ..::.:.....::|::...:|...
  Rat     3 SKTKASEALK-------------VVARCRPLSRKEEAAGH-EQILTMDVKLGQVTLRNPRAAPGE 53

  Fly   165 AGVTHFFSYDQVYYSCDPERKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMG 229
            ...|  |::|.||   |...|    ||.:::.|.|||||:..:|:|..:|||||||:||:|:|.|
  Rat    54 LPKT--FTFDAVY---DASSK----QADLYDETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTMQG 109

  Fly   230 --IEALDDAALDGGPPHDEAGIIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSV 292
              :|.            :..|:||.....:|..|...::||.|   |..||.|||.|:|.||||
  Rat   110 TWVEP------------ELRGVIPNAFEHIFTHISRSQNQQYL---VRASYLEIYQEEIRDLLS- 158

  Fly   293 QHAAAATGESTPIQQQQQQQRPALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATAS 357
                             ::....|:::|:|..|.|:.|||:....:...:.:.:.:||..||..|
  Rat   159 -----------------KEPGKRLELKENPETGVYIKDLSSFVTKNVKEIEHVMNLGNQARAVGS 206

  Fly   358 TAMNDKSSRSHSIFNIVLNLTDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSER------ 416
            |.||:.|||||:||.|.:..::..||   ..|          ..|..|::|||||||||
  Rat   207 THMNEVSSRSHAIFVITVECSERGSD---GQD----------HIRVGKLNLVDLAGSERQNKAGP 258

  Fly   417 --------------------ISVSGSNGERIREGVSINKSLLTLGKVIAALADSRKAIANGPLGS 461
                                .|.|||:|||.:|...||.||..||.||||||.:|
  Rat   259 NTPGGPATQSTAGGGGGGGGTSGSGSSGERPKEASKINLSLSALGNVIAALAGNR---------- 313

  Fly   462 GTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASIHADETLATLRYACKARSIVNRVKVNE 526
               ||.:|||:|.||.||:::||||:||:|:||:.|||...||:|:|||:|.:|::|.|:.:|||
  Rat   314 ---STHIPYRDSKLTRLLQDSLGGNAKTIMVATLGPASHSYDESLSTLRFANRAKNIKNKPRVNE 375

  Fly   527 SPHDKIIRDLRAEVDRLKSLRNEY----ERQRRLSGNSNNPV------PRKIIIETSVDETEVE- 580
            .|.|.::|:.:.|:.|||:...:.    :|.||.|......|      |...:||..|.|.|.:
  Rat   376 DPKDTLLREFQEEIARLKAQLEKKGMLGKRPRRKSSRRKKAVSAPAGYPEGAVIEAWVAEEEDDN 440

  Fly   581 --ALRQQLAERERELSRAQKSWMEKLKEAEDQRKSELRVLKRRGLALELTAEQKQACLVNLTADP 643
              ..|......|..|.:..::::::.||..::.|:.::..:      .|.:|:||..|
  Rat   441 NNNHRPPQPTLEAALEKNMENYLQEQKERLEEEKAAIQDDR------SLVSEEKQKLL------- 492

  Fly   644 ILSGTLFYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVALQHCSIEHERGGKLYVIPGSEDFE 708
                                                             |...|:.     ||.:
  Rat   493 -------------------------------------------------EEKEKML-----EDLK 503

  Fly   709 TYVNG-ELLKDRRQLFHGDRLVIGGSHYFRISNPFCSQRGKADHPVD----FQLAHQEILQ---- 764
            ..... |||..:.:... .:|:|||             |...||..:    .:|..|||.:
  Rat   504 REQQATELLAAKYKAME-SKLLIGG-------------RNIMDHTNEQQKMLELKRQEIAEQKRR 554

  Fly   765 ----KQEQQLRSELEAEKRAALTKIEQE---RAQHARDFEERLQCLELEQFKYKCNSEMLETERQ 822
                :||..||.|...|.|...:.::||   :.:..:....:||.::.|   .:...|.....||
  Rat   555 EREMQQEMLLRDEETMELRGTYSSLQQEVEVKTKKLKKLYAKLQAVKAE---IQDQHEEYIRVRQ 616

  Fly   823 ALALAQQQEHTPLRHE----DAVSTPAQKSTILEDIQRIMLNPSEE 864
            .|..||.::...|:.:    :....|.:|:.|:   .|:.|:..||
  Rat   617 DLEEAQNEQTRELKLKYLIIENFIPPEEKNKIM---NRLFLDCEEE 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	150/433 (35%)
		KISc	120..525	CDD:214526	150/432 (35%)
		Kinesin_assoc	524..657	CDD:292801	32/145 (22%)
		FHA	634..740	CDD:238017	12/106 (11%)
Kif3c	NP_445938.1	KISc_KIF3	9..367	CDD:276822	149/439 (34%)
		Kinesin	16..367	CDD:278646	147/419 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	251..292		9/40 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..421		5/23 (22%)
		GBP_C	<463..571	CDD:303769	31/188 (16%)
		coiled coil	540..551	CDD:293879	4/10 (40%)
		coiled coil	560..571	CDD:293879	5/10 (50%)
		Globular. /evidence=ECO:0000255	633..793		7/30 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	754..796
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000