Protein Alignment neb and KIP1

DIOPT Version :10

• Sequence 1: NP_476817.1
• Gene: neb / 35293
• FlyBaseID: FBgn0004374
• Length: 1121
• Species: Drosophila melanogaster
• Sequence 2: NP_009490.1
• Gene: KIP1 / 852216
• SGDID: S000000159
• Length: 1111
• Species: Saccharomyces cerevisiae
• Alignment Length: 1167
• Identity: 272/1167 - (23%)
• Similarity: 452/1167 - (38%)
• Gaps: 339/1167 - (29%)

  Fly    64 PKPTALNACYTPSSLYRNANSTPGRAKTPGTGKSSCSRTKERDSLMESCLSVSEESNMIVAVRVR 128
            |.|:..|..:|               .||.|    |:..           :.:.:||:.|.||.|
Yeast    26 PSPSLSNGMHT---------------LTPPT----CNNG-----------AATSDSNIHVYVRCR 60

  Fly   129 PLNALECTRGQVTNVVQVHGNSNELTVQAGSSADASAGVTHFFSYDQVYYSCDPERKNFACQAKV 193
            ..|..|........:..:.....|:.:..||....|:. ...:.:||| :..:.:      |..|
Yeast    61 SRNKREIEEKSSVVISTLGPQGKEIILSNGSHQSYSSS-KKTYQFDQV-FGAESD------QETV 117

  Fly   194 FEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMG-------IEALDDAALDGGPPHDEAGIIP 251
            |..||:..|.....|||..:|||||||:||:|:|.|       :::.|:..|.     :.|||||
Yeast   118 FNATAKNYIKEMLHGYNCTIFAYGQTGTGKTYTMSGDINILGDVQSTDNLLLG-----EHAGIIP 177

  Fly   252 RFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQQQQRPAL 316
            |...:||:.:.::..    :..|::|:.|:|||.:.||||                ..:...||:
Yeast   178 RVLVDLFKELSSLNK----EYSVKISFLELYNENLKDLLS----------------DSEDDDPAV 222

  Fly   317 K--VREHPIF-------GPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFN 372
            .  .|:..||       ...|..:....::|.....|.|..|:.:|..|:|..||.|||||::|.
Yeast   223 NDPKRQIRIFDNNNNNSSIMVKGMQEIFINSAHEGLNLLMQGSLKRKVAATKCNDLSSRSHTVFT 287

  Fly   373 IVLNLTDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINKSL 437
            |..|:.:..|.|         ...:....:..|::||||||||.|:.||:..:|.:|...|||||
Yeast   288 ITTNIVEQDSKD---------HGQNKNFVKIGKLNLVDLAGSENINRSGAENKRAQEAGLINKSL 343

  Fly   438 LTLGKVIAALADSRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASIHA 502
            ||||:||.||.|.              |..:|||||.||.||:::|||.:||.::||||||.|..
Yeast   344 LTLGRVINALVDH--------------SNHIPYRESKLTRLLQDSLGGMTKTCIIATISPAKISM 394

  Fly   503 DETLATLRYACKARSIVNRVKVNES-PHDKIIRDLRAEVDRLKSLRNEYERQRRLSG-------- 558
            :||.:||.||.:|:||.|..:||:| ..|..::|...|:::   |||:.:..|...|
Yeast   395 EETASTLEYATRAKSIKNTPQVNQSLSKDTCLKDYIQEIEK---LRNDLKNSRNKQGIFITQDQL 456

  Fly   559 ---NSNNPVPRKIIIETSVDETEVEALRQQL------------------AERERELSRAQK---- 598
               .||:     |:|:.  ...::..||:|:                  :|:|:.::..|.
Yeast   457 DLYESNS-----ILIDE--QNLKIHNLREQIKKFKENYLNQLDINNLLQSEKEKLIAIIQNFNVD 514

  Fly   599 -----SWMEKLKEAEDQRKSELRVLKRRGLALELTAEQ-----------KQACLVNLTADPILSG 647
                 |.::|:.....:..:|  |:::|..:||.:.:|           .|..|..|..   |.|
Yeast   515 FSNFYSEIQKIHHTNLELMNE--VIQQRDFSLENSQKQYNTNQNMQLKISQQVLQTLNT---LQG 574

  Fly   648 TLFYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVALQHCSIEHERGGKLYVIPGSEDFETYVN 712
            :|                  .:.:|:...|:.|       .:.|..|....:........::.:|
Yeast   575 SL------------------NNYNSKCSEVIKG-------VTEELTRNVNTHKAKHDSTLKSLLN 614

  Fly   713 ----------GELLKD---RRQLFHGDRLVIGGSHYFRISNPFCSQRGKADHPVDFQLAHQEILQ 764
                      .||::.   ..::|..|    ..|||.:..|             :...:||:.|:
Yeast   615 ITTNLLMNQMNELVRSISTSLEIFQSD----STSHYRKDLN-------------EIYQSHQQFLK 662

  Fly   765 KQEQQLRSELEAEKRAALTKIEQERAQHARDFEERLQCLELEQFKYKCNSEMLETERQALALAQQ 829
            ..:..::|.|::...:.||.|.                 |:.|   .|.:.:  .....|...||
Yeast   663 NLQNDIKSCLDSIGSSILTSIN-----------------EISQ---NCTTNL--NSMNVLIENQQ 705

  Fly   830 QEHTPLRHEDAVSTPAQKSTILEDIQRIMLNPSEESLHKTQLMVKEATQRCRQLDLPLEFRQTQT 894
            ...:.|..|..:.....|:.::.  :|.:.|...:.|.:.:...::...|.|.     ||.
Yeast   706 SGSSKLIKEQDLEIKKLKNDLIN--ERRISNQFNQQLAEMKRYFQDHVSRTRS-----EFH---- 759

  Fly   895 PDEFGLLRTVILILDKQRGLKAE-W-PTARLGVWLDLV--RDNAEQQEKL--NATTIFQSVEVDW 953
             ||  |.:.:..:.|||..|..: | .||.:....|:|  :.:::....|  ||....::|..:.
Yeast   760 -DE--LNKCIDNLKDKQSKLDQDIWQKTASIFNETDIVVNKIHSDSIASLAHNAENTLKTVSQNN 821

  Fly   954 EPLDADLNETLSDTHNSSRIALNLSAMKDV---LLNKPLKRLLNASSSK-----------SNTPR 1004
            |....||            |:|:.....|:   |.:.|:...||..|..           ::.|.
Yeast   822 ESFTNDL------------ISLSRGMNMDISSKLRSLPINEFLNKISQTICETCGDDNTIASNPV 874

  Fly  1005 QTSTPS----PGSQLVHFTKRLLTYDPEEIPESQSSFTTLVQQE--------------------- 1044
            .||...    ..|.:....:::::.    |.|.||...|:..:.
Yeast   875 LTSIKKFQNIICSDIALTNEKIMSL----IDEIQSQIETISNENNINLIAINENFNSLCNFILTD 935

  Fly  1045 -----LQIMQRSAQRLRRHCE--------------AALLERENHQDNGVLAVSLQEALARMD 1087
                 :||.:...:.|..|||              |..:|:..|:.....| |:.:||..:|
Yeast   936 YDENIMQISKTQDEVLSEHCEKLQSLKILGMDIFTAHSIEKPLHEHTRPEA-SVIKALPLLD 996

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	141/421 (33%)
		SMC_N	514..>615	CDD:481474	27/139 (19%)
		FHA_KIF14	627..741	CDD:438759	20/137 (15%)
KIP1	NP_009490.1	KISc_BimC_Eg5	50..419	CDD:276815	143/424 (34%)
		235kDa-fam	<423..>948	CDD:130673	108/633 (17%)
		AAA_13	<562..>741	CDD:463796	39/247 (16%)