Protein Alignment neb and KIF18A

DIOPT Version :10

• Sequence 1: NP_476817.1
• Gene: neb / 35293
• FlyBaseID: FBgn0004374
• Length: 1121
• Species: Drosophila melanogaster
• Sequence 2: NP_112494.3
• Gene: KIF18A / 81930
• HGNCID: 29441
• Length: 898
• Species: Homo sapiens
• Alignment Length: 1038
• Identity: 252/1038 - (24%)
• Similarity: 402/1038 - (38%)
• Gaps: 331/1038 - (31%)

  Fly   113 LSVSEES---NMIVAVRVRPLNALECTRG--QVTNVVQVH-------------------GNSNEL 153
            :||:||.   :|.|.|||||.|..|...|  :|.:||..|                   .|.|.:
Human     1 MSVTEEDLCHHMKVVVRVRPENTKEKAAGFHKVVHVVDKHILVFDPKQEEVSFFHGKKTTNQNVI 65

  Fly   154 TVQAGSSADASAGVTHFFSYDQVYYSCDPERKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQ 218
            ..|   :.|..      |.:|.|:       ...:.|::|||.|.:|::.:...|||..:.|||.
Human    66 KKQ---NKDLK------FVFDAVF-------DETSTQSEVFEHTTKPILRSFLNGYNCTVLAYGA 114

  Fly   219 TGSGKSYSMMGIEALDDAALDGGPPHDEAGIIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYN 283
            ||:||:::|:|             ..||.|::......|::.::.:|.::  .....|||.|:||
Human   115 TGAGKTHTMLG-------------SADEPGVMYLTMLHLYKCMDEIKEEK--ICSTAVSYLEVYN 164

  Fly   284 EKIHDLLSVQHAAAATGESTPIQQQQQQQRPALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAV 348
            |:|.|||.         .|.|           |.|||....|..|..|:.|...|...:.:.|..
Human   165 EQIRDLLV---------NSGP-----------LAVREDTQKGVVVHGLTLHQPKSSEEILHLLDN 209

  Fly   349 GNSQRATASTAMNDKSSRSHSIFNIVLNLTDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAG 413
            ||..|....|.||..|||||::|.|.|...|             .|||..:..|.:|:||:||||
Human   210 GNKNRTQHPTDMNATSSRSHAVFQIYLRQQD-------------KTASINQNVRIAKMSLIDLAG 261

  Fly   414 SERISVSGSNGERIREGVSINKSLLTLGKVIAALADSRKAIANGPLGSGTPSTFVPYRESVLTWL 478
            |||.|.||:.|.|..||.:||:|||.||.||.|||||::           .:..:|||.|.||.|
Human   262 SERASTSGAKGTRFVEGTNINRSLLALGNVINALADSKR-----------KNQHIPYRNSKLTRL 315

  Fly   479 LRENLGGNSKTVMLATISPASIHADETLATLRYACKARSIVNRVKVNE-------SPHDKIIRDL 536
            |:::||||.:|:|:|.:||:|:..|:|..||:||.:|:.|.:.:|.|.       :.:.||..:.
Human   316 LKDSLGGNCQTIMIAAVSPSSVFYDDTYNTLKYANRAKDIKSSLKSNVLNVNNHITQYVKICNEQ 380

  Fly   537 RAEVDRLKSLRNEYERQRRLSGNS-------NNPVPRKI----------------------IIET 572
            :||:..||.....||.|:..:..:       :||..::|                      .:|.
Human   381 KAEILLLKEKLKAYEEQKAFTNENDQAKLMISNPQEKEIERFQEILNCLFQNREEIRQEYLKLEM 445

  Fly   573 SVDETEVEALRQQLAERERELSRAQKSWMEKLKEAEDQRKSELRVLKRRGLALELTAEQKQACLV 637
            .:.|.|:::..||...::.|:..::    :|:::|..:|...|.:||.|...||...|::
Human   446 LLKENELKSFYQQQCHKQIEMMCSE----DKVEKATGKRDHRLAMLKTRRSYLEKRREEE----- 501

  Fly   638 NLTADPILSGTLFYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVALQHCSIEHERGGKLYVIP 702
                           |.|                      .|.....|..  :|.|.|
Human   502 ---------------LKQ----------------------FDENTNWLHR--VEKEMG------- 520

  Fly   703 GSEDFETYVNGELLKDRRQLFHGDRLVIGGSHYFRISNPFCSQRGKADHPVDFQLAH-QEILQKQ 766
                 ....||.:.|:.::..|        .|:..:.|          ..:..|:.| .::...|
Human   521 -----LLSQNGHIPKELKKDLH--------CHHLHLQN----------KDLKAQIRHMMDLACLQ 562

  Fly   767 EQQLRSELEAEKRAALTKIEQE----------RAQHARDFEERLQCLE-----------LEQFKY 810
            |||.| :.||...|.|..:.::          .|....||:|....:|           .||.|.
Human   563 EQQHR-QTEAVLNALLPTLRKQYCTLKEAGLSNAAFESDFKEIEHLVERKKVVVWADQTAEQPKQ 626

  Fly   811 K----------------------CNSE------MLETERQALALAQQQEHTPLRHEDAVSTPAQK 847
            .                      |:|.      .:.||::.   .::...:||:.:..:.:|..:
Human   627 NDLPGISVLMTFPQLGPVQPIPCCSSSGGTNLVKIPTEKRT---RRKLMPSPLKGQHTLKSPPSQ 688

  Fly   848 STIL---------------EDIQRIMLNPSEESLHK--------------------TQLMVKEA- 876
            |..|               ||.::...|||..:|.|                    .:::.:.|
Human   689 SVQLNDSLSKELQPIVYTPEDCRKAFQNPSTVTLMKPSSFTTSFQAISSNINSDNCLKMLCEVAI 753

  Fly   877 ----TQRCRQLDLPLEF--------RQTQTPDEFGL---LRTVILILDKQR-GLKAEWPTARLGV 925
                .:.|.|.||...|        .:.:.|::..|   .:.::..||... ..|...|...:..
Human   754 PHNRRKECGQEDLDSTFTICEDIKSSKCKLPEQESLPNDNKDILQRLDPSSFSTKHSMPVPSMVP 818

  Fly   926 WLDLVRDNAEQQEKLNATTIFQSVEVDWEPLDADLNETLSDTHNSSRIALNLSAMKDVLLNKP 988
            ....:...|:::.||.::|...|       |.||:|...     :.|:..:.|:.|.:..|||
Human   819 SYMAMTTAAKRKRKLTSSTSNSS-------LTADVNSGF-----AKRVRQDNSSEKHLQENKP 869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	144/429 (34%)
		SMC_N	514..>615	CDD:481474	25/136 (18%)
		FHA_KIF14	627..741	CDD:438759	13/113 (12%)
KIF18A	NP_112494.3	KISc_KIP3_like	11..355	CDD:276821	142/418 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	667..690		3/25 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	830..871		14/52 (27%)