DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment neb and kif1c

DIOPT Version :9

Sequence 1:	NP_476817.1	Gene:	neb / 35293	FlyBaseID:	FBgn0004374	Length:	1121	Species:	Drosophila melanogaster
Sequence 2:	XP_031755447.1	Gene:	kif1c / 779557	XenbaseID:	XB-GENE-997155	Length:	1105	Species:	Xenopus tropicalis

Alignment Length:	1059	Identity:	311/1059 - (29%)
Similarity:	481/1059 - (45%)	Gaps:	244/1059 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 VAVRVRPLNALECTRGQVTNVVQVHGNSNELT--VQAGSSADASAGVTHFFSYDQVYYS-CDPER 184
            |||||||.|:.|... ....|:|:.||:..::  .|...||..       |::|..|:| ...|.
Frog     8 VAVRVRPFNSREIAH-DAKCVIQMQGNTTCISNPKQPKDSAKN-------FTFDYSYWSHTTAED 64

  Fly   185 KNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGPPHDEAGI 249
            .|||.|.:|::.....::..||||||.|:||||||||||||:||           |.|..::.||
Frog    65 PNFASQCQVYKDIGEEMLLHAFEGYNVCIFAYGQTGSGKSYTMM-----------GKPESEQHGI 118

  Fly   250 IPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQQQQRP 314
            ||:.|.:||.|:.|.:| ..|...|||||.|||.|::.|||:                  .:.:.
Frog   119 IPQLCEDLFARVSANRS-PDLSCSVEVSYMEIYCERVRDLLN------------------PKSKG 164

  Fly   315 ALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNIVLNLTD 379
            .|:||||||.||||.|||..:|.||..:.:.:..||..|..|:|.||:.|||||::|.||  .|.
Frog   165 NLRVREHPIMGPYVEDLSKLAVTSYHDIADLMDCGNKARTVAATNMNETSSRSHAVFTIV--FTQ 227

  Fly   380 LSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINKSLLTLGKVI 444
            ...|:..:.||:          :.|||||||||||||...:|:.|.|::||.:|||||.||||||
Frog   228 KRHDEMTNLDTE----------KVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVI 282

  Fly   445 AALADSRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASIHADETLATL 509
            :|||:.:        .....|.|:|||:|.|||||:|||||||:|.|:|.:|||.|:.:|||:||
Frog   283 SALAEMQ--------NKKKKSDFIPYRDSALTWLLKENLGGNSRTAMIAALSPADINYEETLSTL 339

  Fly   510 RYACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSLRNEYERQRRLSGNSNN------------ 562
            |||.:|:.|.....:||.|:.::||:|:.||.||:.|......:..:..:|.:
Frog   340 RYADRAKQIKCNAVINEDPNARLIRELKEEVARLRQLLYSQGLEDIVIDDSASAPHPPSPAAAPV 404

  Fly   563 ---PVPRKII-------------IETSVDETEV--EALRQQLAERERELSRAQKSWMEKLKEAED 609
               |:|..:.             .....|..|:  |...::|.|.|:.::...::|.|||::.|.
Frog   405 SPPPLPGSLAPLASPTQNGQSEPFPEGEDAAEICTEEAMERLQETEKIIAELNETWEEKLRKTEA 469

  Fly   610 QRKSELRVLKRRGLALE-------LTAEQKQACLVNLTADPILSGTLFYLLPQGLVRIGRGRLPG 667
            .|.....:|...|:|:.       :.:.:|...||||..||::|..|.|.:.:|:.|:|:
Frog   470 LRTEREALLAEMGVAVREDGGTVGVFSPKKIPHLVNLNEDPLMSECLLYHIKEGITRVGQ----- 529

  Fly   668 GSSSSQPDIVLDGPLVALQHCSIE---HERGGKLYVIPGSEDFETYVNGELLKDRRQLFHGDRLV 729
                .:.||.|.|..:..|||...   :..|..:..:...|..||||||:|:.....|..|.|:|
Frog   530 ----VEVDIKLSGQFIKEQHCLFHCDTNPSGEVIVTLEPCEGAETYVNGKLVTQALVLKSGTRIV 590

  Fly   730 IGGSHYFRISNP----FCSQRGKA-----DHPVDFQLAHQEILQKQEQQLRSELE---------- 775
            :|.:|.||.::|    ...:|..|     ..|||:..|.:|:|:||...::.|:|
Frog   591 MGKNHVFRFNHPEQARLERERSSAAIENPSEPVDWNFAQKELLEKQGIDIKLEMEKRLQDLEYQY 655

  Fly   776 -AEKRAALTKIEQERA---QHARDFEERLQCLE----------------LEQFKYKCNSEMLETE 820
             .||..|...:||:|.   ..:.|..::..|.|                ::....:|.......:
Frog   656 KKEKEEADLTLEQQRLYADSDSGDDSDKRSCEESWRLISSLREKVPAGRVQSIVRRCGLPSSGKK 720

  Fly   821 RQALALAQQQEHTPLRHEDAVSTPA--QKSTILEDIQRIMLNPSEESLHKTQLM-VKEATQRCRQ 882
            |:.:.:.|..:...|..:....|.|  :...:.|....:.||..:.|..:.:.| |.:..:.||
Frog   721 REPIRVYQIPQRRRLGKDPRWLTLADLKMQAVKEICYEVALNDFKHSRQEIEAMSVIKMKELCR- 784

  Fly   883 LDLPLEFRQTQTPDEFGLLRTVILILDKQRGL--KAEWPTARLGVW--------------LDLVR 931
                          .:|           :|.:  |..|......||              :..|:
Frog   785 --------------TYG-----------KRDINEKELWKAVARDVWDTVGVGEEDAGTKSVSGVQ 824

  Fly   932 DNAEQQEKLNATTIFQSVEVDWEPLDADLNETLSDTHNSSRIALNLSAMKDVLLNKPLKRLLNAS 996
            |.....:||  |.|.|.|:         |...:.|.        .:.:::|.::.  ::|::..:
Frog   825 DLKAHIDKL--TDILQEVK---------LQNNMKDE--------EIRSLRDRMIK--MERVMPLA 868

  Fly   997 SSK--------------SNTPRQTSTPSPGSQLV--HFTKRLLTYDP--EEIPESQSSFTT---- 1039
            ...              ||..::...|| ||.|.  |..|     :|  :::.:..::|..
Frog   869 QDNGDEDYLDEQSLPWYSNENQEIPEPS-GSGLSPDHSPK-----EPRVDQLMDEDATFRRGRMR 927

  Fly  1040 -LVQQELQIMQRSAQRLRR 1057
             |.|::.:|.....|::.|
Frog   928 WLKQEQTRIQNLQQQQINR 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	175/404 (43%)
		KISc	120..525	CDD:214526	175/404 (43%)
		Kinesin_assoc	524..657	CDD:292801	39/169 (23%)
		FHA	634..740	CDD:238017	36/108 (33%)
kif1c	XP_031755447.1	KISc_KIF1A_KIF1B	4..355	CDD:276816	175/404 (43%)
		Kinesin_assoc	352..524	CDD:406567	39/171 (23%)
		FHA	501..601	CDD:238017	36/108 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010