Protein Alignment neb and KIF13A

DIOPT Version :9

• Sequence 1: NP_476817.1
• Gene: neb / 35293
• FlyBaseID: FBgn0004374
• Length: 1121
• Species: Drosophila melanogaster
• Sequence 2: NP_071396.4
• Gene: KIF13A / 63971
• HGNCID: 14566
• Length: 1805
• Species: Homo sapiens
• Alignment Length: 1011
• Identity: 315/1011 - (31%)
• Similarity: 477/1011 - (47%)
• Gaps: 219/1011 - (21%)

  Fly   118 ESNMIVAVRVRPLNALE------CTRGQVTNVVQVHGNSNELTVQAGSSADASAGVTHFFSYDQV 176
            ::.:.|||||||:|..|      |       ||::.||...|.....::..........|::|..
Human     3 DTKVKVAVRVRPMNRRELELNTKC-------VVEMEGNQTVLHPPPSNTKQGERKPPKVFAFDYC 60

  Fly   177 YYSCDPER-KNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDG 240
            ::|.|... ..:|.|..||:.....:::.||:|||||:|||||||||||:||||
Human    61 FWSMDESNTTKYAGQEVVFKCLGEGILEKAFQGYNACIFAYGQTGSGKSFSMMG----------- 114

  Fly   241 GPPH-DEAGIIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTP 304
               | ::.|:|||.|..||:||...:::.| ..:|||||.||||||:.|||
Human   115 ---HAEQLGLIPRLCCALFKRISLEQNESQ-TFKVEVSYMEIYNEKVRDLL-------------- 161

  Fly   305 IQQQQQQQRPALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHS 369
               ..:..|.:||||||.:.||||..||..:|.|:..:.:.::.||..|..|:|.||::|||||:
Human   162 ---DPKGSRQSLKVREHKVLGPYVDGLSQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHA 223

  Fly   370 IFNIVLNLTDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSIN 434
            :|||::..|......|.|.:            :.||:||||||||||:|.:|:.|||::||.:||
Human   224 VFNIIITQTLYDLQSGNSGE------------KVSKVSLVDLAGSERVSKTGAAGERLKEGSNIN 276

  Fly   435 KSLLTLGKVIAALADSRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPAS 499
            |||.|||.||::|||.       ..|.| .|.|||||:|||||||::||||||:|.|:||||||:
Human   277 KSLTTLGLVISSLADQ-------AAGKG-KSKFVPYRDSVLTWLLKDNLGGNSQTSMIATISPAA 333

  Fly   500 IHADETLATLRYACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSLRNEYERQRRLSGNSNNPV 564
            .:.:|||:|||||.:|:.|||...|||.|:.|:||:||.||::|:...::.|..:
Human   334 DNYEETLSTLRYADRAKRIVNHAVVNEDPNAKVIRELREEVEKLREQLSQAEAMK---------- 388

  Fly   565 PRKIIIETSVDETEVEALRQQLAERERELSRAQKSWMEKLKEAEDQRKSELRVLKRRGLALELT- 628
                          ...|:::|.|.|:.:.....:|.|||::.|:..:...|.|:..|::||::
Human   389 --------------APELKEKLEESEKLIKELTVTWEEKLRKTEEIAQERQRQLESMGISLEMSG 439

  Fly   629 --AEQKQACLVNLTADPILSGTLFYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVALQHCSIE 691
              ....:..||||.|||.|:..|.|.| :...|:       |:.:|| ||.|.|..:..|||.|:
Human   440 IKVGDDKCYLVNLNADPALNELLVYYL-KDHTRV-------GADTSQ-DIQLFGIGIQPQHCEID 495

  Fly   692 HERGGKLYVIPGSEDFETYVNGELLKDRRQLFHGDRLVIGGSHYFRISNP----------FCSQR 746
            ....|.:.:.| .|:..:.|||.|:....||:||||::.|.:|:|||:.|          |..:.
Human   496 IASDGDVTLTP-KENARSCVNGTLVCSTTQLWHGDRILWGNNHFFRINLPKRKRRDWLKDFEKET 559

  Fly   747 GKADHPVD------------FQLAHQEILQKQ----------EQQLRSELEAEKRAALTKIEQER 789
            |..:|.:|            ::.|..|::.|.          .|.|..:...|||:||   |::|
Human   560 GPPEHDLDAASEASSEPDYNYEFAQMEVIMKTLNSNDPVQNVVQVLEKQYLEEKRSAL---EEQR 621

  Fly   790 AQHARDFEERLQCLELEQFKYKCNSEMLETERQALALAQQQEHTPLRHEDAVSTPAQKST----I 850
            ..:.|         ||||.:     :.|..:|      |.|...|.|...:..|..||.|    .
Human   622 LMYER---------ELEQLR-----QQLSPDR------QPQSSGPDRLAYSSQTAQQKVTQWAEE 666

  Fly   851 LEDIQRIMLNPSEESLHKTQLMVKEATQRCRQLDLPLEFRQT-QTPDEFGLLRTVILILDKQRGL 914
            .:::.|..|....|.|.|...:|:||.....::....:::.| |.|       ...|..:::||.
Human   667 RDELFRQSLAKLREQLVKANTLVREANFLAEEMSKLTDYQVTLQIP-------AANLSANRKRGA 724

  Fly   915 KAEWPTARLGVWLDLVRDNAEQQEKLNATTIFQSVE------VDWEPLDADLNETL--------- 964
                          :|.:.|.|..:...:|...::|      :|...|..:..|.:
Human   725 --------------IVSEPAIQVRRKGKSTQVWTIEKLENKLIDMRDLYQEWKEKVPEAKRLYGK 775

  Fly   965 --------SDTHNSSRIALNLSAMKDVLLNKPLKRLLNASSSKSNTPRQTSTPSPGSQLVHFTKR 1021
                    .:.||...:|           |..|:.|......:...|..:.......:|.....|
Human   776 RGDPFYEAQENHNLIGVA-----------NVFLECLFCDVKLQYAVPIISQQGEVAGRLHVEVMR 829

  Fly  1022 LLTYDPEEIPESQSSFTTLVQQELQIMQRSAQRLRR 1057
            :....||.:.|..||..:.....|:::..|.:.:.|
Human   830 VTGAVPERVVEDDSSENSSESGSLEVVDSSGEIIHR 865

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	176/413 (43%)
		KISc	120..525	CDD:214526	176/412 (43%)
		Kinesin_assoc	524..657	CDD:292801	38/135 (28%)
		FHA	634..740	CDD:238017	41/105 (39%)
KIF13A	NP_071396.4	KISc_KIF1A_KIF1B	5..359	CDD:276816	176/412 (43%)
		Kinesin_assoc	356..468	CDD:318424	38/136 (28%)
		FHA	446..543	CDD:238017	41/106 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	556..575		3/18 (17%)
		SMC_N	<606..771	CDD:330553	44/208 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	633..656		6/28 (21%)
		KIF1B	748..792	CDD:315155	5/43 (12%)
		DUF3694	<1215..1279	CDD:315198
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1385..1404
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1507..1531
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1612..1645
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1749..1779

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920