Protein Alignment neb and KIF17

DIOPT Version :10

• Sequence 1: NP_476817.1
• Gene: neb / 35293
• FlyBaseID: FBgn0004374
• Length: 1121
• Species: Drosophila melanogaster
• Sequence 2: XP_047282102.1
• Gene: KIF17 / 57576
• HGNCID: 19167
• Length: 1063
• Species: Homo sapiens
• Alignment Length: 1081
• Identity: 271/1081 - (25%)
• Similarity: 411/1081 - (38%)
• Gaps: 327/1081 - (30%)

  Fly   123 VAVRVRPLN------------ALECTRGQVTNVVQVHGNSNELTVQAGSSADASAGVTHFFSYDQ 175
            |.||.||:|            .::|.|.|.  .:|..|.::|...|              |::|.
Human     8 VVVRCRPMNQRERELRCQPVVTVDCARAQC--CIQNPGAADEPPKQ--------------FTFDG 56

  Fly   176 VYYSCDPERKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDG 240
            .|: .|...:      :::...|.||::...||||..:|||||||||||::|.|:.
Human    57 AYH-VDHVTE------QIYNEIAYPLVEGVTEGYNGTIFAYGQTGSGKSFTMQGLP--------- 105

  Fly   241 GPPHDEAGIIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPI 305
             .|..:.|||||....:|   |:|:..:..:..|..||.|||||.:.|||         |..|
Human   106 -DPPSQRGIIPRAFEHVF---ESVQCAENTKFLVRASYLEIYNEDVRDLL---------GADT-- 155

  Fly   306 QQQQQQQRPALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSI 370
                   :..|:::|||..|.||..||.|:|.|.:...:.:..|...|:...|.||..|||||||
Human   156 -------KQKLELKEHPEKGVYVKGLSMHTVHSVAQCEHIMETGWKNRSVGYTLMNKDSSRSHSI 213

  Fly   371 FNIVLNLTDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINK 435
            |.|.:   ::|:.|....|          ..|..|::|||||||||.|.:|:.|||::|...||.
Human   214 FTISI---EMSAVDERGKD----------HLRAGKLNLVDLAGSERQSKTGATGERLKEATKINL 265

  Fly   436 SLLTLGKVIAALADSRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASI 500
            ||..||.||:||.|.|             ...||||:|.||.||:::||||:||:|:|.:|||..
Human   266 SLSALGNVISALVDGR-------------CKHVPYRDSKLTRLLQDSLGGNTKTLMVACLSPADN 317

  Fly   501 HADETLATLRYACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSLRNEYERQRRLSGNSNNPVP 565
            :.||||:|||||.:|::|.|:.::||.|.|.::|:.:.|:.:||::..:......||...:..||
Human   318 NYDETLSTLRYANRAKNIRNKPRINEDPKDALLREYQEEIKKLKAILTQQMSPSSLSALLSRQVP 382

  Fly   566 -------RKIIIETSVD---ETEVEALRQQLAER------------------ERELSRAQKSWME 602
                   .|::.:..:.   |.|.:.:|::..||                  |.:::..:.|:..
Human   383 PDPVQVEEKLLPQPVIQHDVEAEKQLIREEYEERLARLKADYKAEQESRARLEEDITAMRNSYDV 447

  Fly   603 KLKEAEDQRKSELRVLKRRGLALEL----------TAEQKQACLVNLTADPILSGTL-------- 649
            :|...|:..:.|...:.:.|:..:.          :||...|........|.:..|.
Human   448 RLSTLEENLRKETEAVLQVGVLYKAEVMSRAEFASSAEYPPAFQYETVVKPKVFSTTDTLPSDDV 512

  Fly   650 --------FYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVALQHCSIEHERGGKLYVIPGSED 706
                    |..||:  |...:..:..|||.|.          :|:..|:..       ..||.|:
Human   513 SKTQVSSRFAELPK--VEPSKSEISLGSSESS----------SLEETSVSE-------AFPGPEE 558

  Fly   707 FETYVNGELLKDRRQLFHGDRLVIGGSHYFRISNPFCSQRGKADHPVDFQLAHQEILQKQEQQLR 771
            ..........::.|            |.||...   |..:..|.|    .|..|..|.::|.|
Human   559 PSNVEVSMPTEESR------------SRYFLDE---CLGQEAAGH----LLGEQNYLPQEEPQ-- 602

  Fly   772 SELEAEKRAALTKIEQERAQHARDFEERLQCLELEQFKYKCNSEMLETERQALALAQQQEHTPLR 836
                                     |..||.|      ........|.|.:...|:.....|...
Human   603 -------------------------EVPLQGL------LGLQDPFAEVEAKLARLSSTVARTDAP 636

  Fly   837 HEDAVSTPAQKSTILEDIQRIMLNPSEESLHKTQLMVKEATQRCRQLDLPLEFRQTQTPDEF--- 898
            ..|....|.|.....:     :|.||:..                        .:.:..|:|
Human   637 QADVPKVPVQVPAPTD-----LLEPSDAR------------------------PEAEAADDFPPR 672

  Fly   899 ---GLLRTVILILDKQRGLKAEWPTARLGVWLDLVRDNA--EQQEKLNATTIFQSVEVDWEPLDA 958
               .|...|.|.:.:         ||..||||:.....|  .|.|.|.||...:...|..|.  |
Human   673 PEVDLASEVALEVVR---------TAEPGVWLEAQAPVALVAQPEPLPATAGVKRESVGMEV--A 726

  Fly   959 DLNETLSDTHNSSRIALNLSAMKDVLL------NKPLKR-------------------------- 991
            .|.:......:..::...|..::..::      ||.||.
Human   727 VLTDDPLPVVDQQQVLARLQLLEQQVVGGEQAKNKDLKEKHKRRKRYADERRKQLVAALQNSDED 791

  Fly   992 -----LLNASSSKSNTPRQTSTPSPGSQLVHFTKRLLTYDPEEIPESQSSF--------TTLVQQ 1043
                 |||...|.....|..      |:|:...:|.|.....||.:.||.|        .|:.:|
Human   792 SGDWVLLNVYDSIQEEVRAK------SKLLEKMQRKLRAAEVEIKDLQSEFQLEKIDYLATIRRQ 850

  Fly  1044 E------LQIMQRSAQRLRRHCEAALLE---REN--HQDNG 1073
            |      .|::::....:||.|..:.||   ||:  .:|||
Human   851 ERDSMLLQQLLEQVQPLIRRDCNYSNLEKILRESCWDEDNG 891

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	149/413 (36%)
		SMC_N	514..>615	CDD:481474	25/128 (20%)
		FHA_KIF14	627..741	CDD:438759	22/139 (16%)
KIF17	XP_047282102.1	Motor_domain	4..335	CDD:473979	147/406 (36%)