DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment neb and kif13ba

DIOPT Version :9

Sequence 1:	NP_476817.1	Gene:	neb / 35293	FlyBaseID:	FBgn0004374	Length:	1121	Species:	Drosophila melanogaster
Sequence 2:	XP_005169924.1	Gene:	kif13ba / 571520	ZFINID:	ZDB-GENE-070521-1	Length:	1822	Species:	Danio rerio

Alignment Length:	940	Identity:	313/940 - (33%)
Similarity:	451/940 - (47%)	Gaps:	213/940 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 ESNMIVAVRVRPLNALE------CTRGQVTNVVQVHGNSNELTVQAGSSADASAGVTHFFSYDQV 176
            :||:.|||||||:|..|      |       ||::.||...| .......|:|.|....|:||..
Zfish     8 DSNVKVAVRVRPMNRREKDLNTKC-------VVEMEGNQTFL-YSTNLGKDSSRGQPKTFAYDYC 64

  Fly   177 YYSCD-PERKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDG 240
            ::|.| .|.:.||.|..||:.....|:..||:|||||:||||||||||||:|||
Zfish    65 FWSMDESETEKFAGQDVVFQCLGESLLHNAFQGYNACIFAYGQTGSGKSYTMMG----------- 118

  Fly   241 GPPHDEAGIIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPI 305
              ..|:.|:|||.|..||.| ..:..:::....|||||.||||||:.|||
Zfish   119 --SVDQPGLIPRLCSSLFER-TVLHQREEESFTVEVSYMEIYNEKVRDLL--------------- 165

  Fly   306 QQQQQQQRPALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSI 370
              ..:..|.||:||||.:.||||..||..:|:||..:.:.::.||..|..|:|.||::|||||::
Zfish   166 --DPKGSRQALRVREHKVLGPYVDGLSRLAVESYKDIESLMSEGNKSRTVAATNMNEESSRSHAV 228

  Fly   371 FNIVL--NLTDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSI 433
            |||:|  .|.||.|  |.|.:            :.||:||||||||||.:.:|:.|||::||.:|
Zfish   229 FNIILTHTLKDLQS--GTSGE------------KVSKLSLVDLAGSERAAKTGAAGERLKEGSNI 279

  Fly   434 NKSLLTLGKVIAALADSRKAIANGPLGSG-TPSTFVPYRESVLTWLLRENLGGNSKTVMLATISP 497
            ||||.|||.||:||||.         |:| ..:.|||||:|||||||:::|||||:|.|:||:||
Zfish   280 NKSLTTLGLVISALADQ---------GAGKNKNKFVPYRDSVLTWLLKDSLGGNSRTAMVATVSP 335

  Fly   498 ASIHADETLATLRYACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSLRNEYERQRRLSGNSNN 562
            |:.:.||||:|||||.:|:||||...|||.|:.:|||:||.||::|:...
Zfish   336 AADNYDETLSTLRYADRAKSIVNHAVVNEDPNARIIRELREEVEKLRDQL--------------- 385

  Fly   563 PVPRKIIIETSVDETEVEALRQQLAERERELSRAQKSWMEKLKEAEDQRKSELRVLKRRGLALE- 626
                     |..:..:...|:::|.|.|:.:.....:|.|||::.|:..:...:.|:..|::|:
Zfish   386 ---------TQAESMKAPELKERLEESEKLIQEMTVTWEEKLRKTEEIAQERQKQLESLGISLQS 441

  Fly   627 --LTAEQKQACLVNLTADPILSGTLFYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVALQHCS 689
              :...:.:..||||.|||.|:..|.|.|.:        ....||:.|| ||.|.|..:..:||.
Zfish   442 SGIKVGEDKCFLVNLNADPALNELLVYYLKE--------HTKVGSADSQ-DIQLCGMGIQAEHCV 497

  Fly   690 IEHERGGKLYVIPGSEDFETYVNGELLKDRRQLFHGDRLVIGGSHYFRISNPFCSQRGKADH--- 751
            |.....|.:::.| ..:..|.|||..:..|:||.||||::.|.:|:|||:.|....||:.:.
Zfish   498 INITPEGAVFINP-YRNSRTCVNGSPVTSRQQLHHGDRILWGNNHFFRINLPKRRLRGEEEEGEG 561

  Fly   752 --------------------------PVDFQLAHQEILQKQ----------EQQLRSELEAEKRA 780
                                      ...::.|..|::.|.          .|.|..:.|.|||.
Zfish   562 GNMKSSNSNEQLDGEGDTASEVSSEVSFSYEFAQTEVMMKALGSNDPMQAVLQSLERQHEEEKRT 626

  Fly   781 ALTKIEQERAQHARDFEERLQCLELEQFKYKCNSEMLETERQALALAQQQEHTP-LRHEDAVSTP 844
            ||   |::|..:.:         ||:|.:     ..|..:||::.:.|.|...| .|..:.:|..
Zfish   627 AL---ERQRLMYEQ---------ELQQLR-----RQLTPDRQSMQIPQSQPLQPHYRSMERLSQG 674

  Fly   845 AQKSTILEDIQRIMLNPSEE-------SLHK-------TQLMVKEATQRCRQLDLPLEFRQT-QT 894
            ...|:  ...|..:...|||       ||.|       ..|:|:||:....:||...|:|.| |.
Zfish   675 GMSSS--SSAQHRLRQWSEEREVVLTRSLRKLREQIVRANLLVQEASFIAEELDKRTEYRVTLQI 737

  Fly   895 P---------DEFGLLRTVILILDKQRGLKAEWPTARL-----------GVWLDLVRDNAEQQEK 939
            |         .:..|....|.:..|.:| |..|...::           ..|.|...||:..:..
Zfish   738 PAANLNANRKRDAVLSEPAIQVRRKGKG-KQIWALEKMENRLVDMRELYQEWKDFDEDNSVMRSY 801

  Fly   940 LNATTIFQSVEVDWEPLDADLNETLSDTHN 969
            ......|         .|..:|.:|....|
Zfish   802 FKRADPF---------FDEQVNHSLIGVAN 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	187/415 (45%)
		KISc	120..525	CDD:214526	186/414 (45%)
		Kinesin_assoc	524..657	CDD:292801	36/135 (27%)
		FHA	634..740	CDD:238017	40/105 (38%)
kif13ba	XP_005169924.1	KISc_KIF1A_KIF1B	9..363	CDD:276816	187/415 (45%)
		KISc	10..363	CDD:214526	186/414 (45%)
		Kinesin_assoc	360..472	CDD:292801	36/135 (27%)
		FHA	450..547	CDD:238017	40/106 (38%)
		KIF1B	774..820	CDD:289208	8/54 (15%)
		DUF3585	<1100..1161	CDD:304905
		DUF3694	<1239..1297	CDD:289256
		CAP_GLY	1718..1781	CDD:279625
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920