DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment neb and kif1ab

DIOPT Version :9

Sequence 1:	NP_476817.1	Gene:	neb / 35293	FlyBaseID:	FBgn0004374	Length:	1121	Species:	Drosophila melanogaster
Sequence 2:	XP_009296795.1	Gene:	kif1ab / 566766	ZFINID:	ZDB-GENE-070912-480	Length:	1799	Species:	Danio rerio

Alignment Length:	928	Identity:	297/928 - (32%)
Similarity:	462/928 - (49%)	Gaps:	190/928 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 VAVRVRPLNALECTRGQVTNVVQVHGNSNELTVQAGSSADASAGVTHFFSYDQVYYS-CDPERKN 186
            |||||||.|:.|..:.... ::|:.||:..:........:.|      |::|..|:| ..||..|
Zfish     8 VAVRVRPFNSREIGKDSKC-IIQMSGNTTTILNPKQPKENKS------FNFDYSYWSHTTPEDVN 65

  Fly   187 FACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGPPHDEAGIIP 251
            :|||.:|:......::..||||||.|:|||||||:||||:|||.:           ..|:.||||
Zfish    66 YACQKQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQ-----------EKDQEGIIP 119

  Fly   252 RFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQQQQRPAL 316
            ..|.:||.:|.. .:...:...|||||.|||.|::.|||:                  .:.:..|
Zfish   120 LLCEDLFTKIND-NNDNNMSYSVEVSYMEIYCERVRDLLN------------------PKNKGNL 165

  Fly   317 KVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNIVLNLTDLS 381
            :|||||:.||||.|||..:|.||:.:::.:..||..|..|:|.||:.|||||::|||:  .|...
Zfish   166 RVREHPLMGPYVEDLSKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNII--FTQKQ 228

  Fly   382 SDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINKSLLTLGKVIAA 446
            .|    :|::::|      .:.|||||||||||||...:|:.|.|::||.:|||||.||||||:|
Zfish   229 HD----NDSENTT------EKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISA 283

  Fly   447 LADSRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASIHADETLATLRY 511
            ||:...| .|.........:|:|||:|||||||||||||||:|.|:|.:|||.|:.||||:||||
Zfish   284 LAEMDSA-PNKNKKKKKVESFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRY 347

  Fly   512 ACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSL----------------------------RN 548
            |.:|:.|.....:||.|:::::|:|:.||.|||.|                            |.
Zfish   348 ADRAKQIRCNAVINEDPNNRLVRELKEEVARLKDLLYAQGLGDIIENLSNYKANISSIQAVNQRG 412

  Fly   549 EYER-QRRLSGNSNNP--------------VPRKIIIETSVDETEVEALRQQLAERERELSRAQK 598
            ::.. ...::|.|.:|              :..:|:.....:|. :|.|:    |.|:.::...:
Zfish   413 DFSTVTNAMTGMSPSPSLSALTSRVGSISSLHDRIMFSPGSEEA-IERLK----ETEKIIAELNE 472

  Fly   599 SWMEKLKEAEDQRKSELRVLKRRGLALE-------LTAEQKQACLVNLTADPILSGTLFYLLPQG 656
            :|.|||:..|..|.....:|...|:|:.       :.:.:|...||||..||::|..|.|.:..|
Zfish   473 TWEEKLRRTEAIRMEREALLAEMGVAMREDGGTVGVFSPKKTPHLVNLNEDPLMSECLLYYIKDG 537

  Fly   657 LVRIGRGRLPGGSSSSQPDIVLDGPLVALQHC---SIEHERGGKLYVIPGSEDFETYVNGELLKD 718
            :.::||     ..:||:.||||.|..:..:||   |..:..|....|:...|..||||||:.:.:
Zfish   538 ITKVGR-----EDASSRQDIVLSGHFIKDEHCIFTSTTNAIGEGTVVLEPCEGAETYVNGKRVTE 597

  Fly   719 RRQLFHGDRLVIGGSHYFRISNPFCSQRGK-----AD---HPVDFQLAHQEILQKQE-------- 767
            ...|..|:|:::|.||.||.::|..:::.:     ||   .|||:..|.:|:|:||.
Zfish   598 PTVLKSGNRIIMGKSHVFRFNDPEQARQDRERTPCADTPVEPVDWAFAQRELLEKQGIDMKQEMD 662

  Fly   768 ---QQLRSELEAEKRAALTKIEQERAQHARDFEERLQCLELEQFKYKCNSEMLETERQALALAQQ 829
               |:|..:...|:..|...:||:|.    |:|.:|:.|: :|...:...|..|.|.:.
Zfish   663 QRLQELEDQYRKEREEASNLLEQQRL----DYESKLEALQ-KQVNSRYYPETTEEEEEL------ 716

  Fly   830 QEHTP-LRHEDAVSTPAQKS------TILEDIQRIMLNPSEESLHKTQLMVKEATQRCRQLDLPL 887
            ::..| .:.|..::..|.:.      |.|.|:           |....:.:|||.....:|...:
Zfish   717 EDEVPWTKRETELALWAFRKWRFYQFTSLRDL-----------LWGNAIFLKEANAISVELKKKV 770

  Fly   888 EFR---QTQT------PDEFGLL--------------RTVIL--ILDKQRGLKAEWPTARLGVWL 927
            :|:   .|.|      ||   ||              ||::.  :.|::.|....|...:|...|
Zfish   771 QFQFVLLTDTLYSPLPPD---LLPPSIAKDREKRLFPRTIVAVEVQDQKNGATHYWTLDKLRQRL 832

  Fly   928 DLVRDNAEQQEKLNATTI 945
            ||:|:..::..::.:|.:
Zfish   833 DLMREMYDRAAEVPSTAV 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	172/402 (43%)
		KISc	120..525	CDD:214526	172/402 (43%)
		Kinesin_assoc	524..657	CDD:292801	40/182 (22%)
		FHA	634..740	CDD:238017	39/108 (36%)
kif1ab	XP_009296795.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	172/402 (43%)
		KISc	5..361	CDD:214526	172/402 (43%)
		Kinesin_assoc	358..538	CDD:292801	40/184 (22%)
		FHA	515..618	CDD:238017	39/107 (36%)
		ATP-synt_B	<647..696	CDD:304375	14/52 (27%)
		KIF1B	828..874	CDD:289208	6/23 (26%)
		DUF3694	1320..1428	CDD:289256
		PH_KIFIA_KIFIB	1680..1782	CDD:269939
		PH	1685..1778	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0245
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820