DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment neb and kif14

DIOPT Version :9

Sequence 1:	NP_476817.1	Gene:	neb / 35293	FlyBaseID:	FBgn0004374	Length:	1121	Species:	Drosophila melanogaster
Sequence 2:	XP_005170522.1	Gene:	kif14 / 562052	ZFINID:	ZDB-GENE-030131-5759	Length:	1506	Species:	Danio rerio

Alignment Length:	1273	Identity:	402/1273 - (31%)
Similarity:	616/1273 - (48%)	Gaps:	275/1273 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 NK--STPVRQRIQQFQ----TRGVHKSTPASEMRKKVLMTRAEDREHRDRPEQLLNTAFSGSTPQ 61
            ||  |||.|:  .||:    .|.|.:.....:..|.........|  ..:|.|:  ::.||.:..
Zfish   112 NKTVSTPTRR--TQFEKLSVKRDVFEKLAGKDASKPTFPKPGSAR--GAKPPQM--SSESGRSAG 170

  Fly    62 PKPKPTALNACYTPSS----LYRNA----NSTP--GR---AKTPGTGKSSCSRTKERDSLMESCL 113
            .|.....||...||:|    :.|.|    :|||  ||   ..||..|.|..|..:.::..||:
Zfish   171 EKLLVGGLNRHMTPASQPAQVRRPAGLMSSSTPHGGRRVEGHTPAEGLSKMSELQTQELKMEN-- 233

  Fly   114 SVSEESNMIVAVRVRPLNALECTRGQVTNVVQVHGNSNELT-VQAGSSADASAGVTHFFSYDQVY 177
                 |.:.|||||||.:    :|.::....||....|:.| ||...:..     ||.|::|..:
Zfish   234 -----SAVTVAVRVRPFS----SREKIEKACQVIFMENQDTLVQHPDTKQ-----THKFTFDFSF 284

  Fly   178 YSCDPERKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGP 242
            .|.:....:|:.|..::|..||||::.||||:|.||||||||||||||:|||.
Zfish   285 CSINEADASFSSQQLIYEKLARPLLERAFEGFNTCLFAYGQTGSGKSYTMMGF------------ 337

  Fly   243 PHDEAGIIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQ 307
             .:|.|:|||||.|||.|: |....:::...:|:||||:|||||||||..             :.
Zfish   338 -GEETGVIPRFCEELFSRL-ARSETKEMSCHLEMSYFEVYNEKIHDLLVA-------------KD 387

  Fly   308 QQQQQRPALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFN 372
            :|.|::..|:|||||::||||.|||.:.|.|||.::.||.:||.|||||:|.||||||||||:|.
Zfish   388 EQNQKKMPLRVREHPVYGPYVADLSTNVVSSYSDIKTWLELGNKQRATAATGMNDKSSRSHSVFT 452

  Fly   373 IVLNLTDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINKSL 437
            :|:..|          .|:............|:|:|||||||||.:.:.::|:|:|||.||||||
Zfish   453 LVMTQT----------KTEFVEEEEHDHCITSRINLVDLAGSERCTSAQTSGDRLREGASINKSL 507

  Fly   438 LTLGKVIAALAD---SRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPAS 499
            |||||||::|::   |||.:            |.|||||||||||:|:|||||||.|:||:|||:
Zfish   508 LTLGKVISSLSEQSQSRKKV------------FTPYRESVLTWLLKESLGGNSKTAMIATLSPAA 560

  Fly   500 IHADETLATLRYACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSLRNEYERQRRLSGNSNNPV 564
            .:.:|:|:|||||.:||.|:|..||||..:.|:||||:|||::|        |..::|.....|.
Zfish   561 SNMEESLSTLRYAQQARMIINIAKVNEDTNAKLIRDLKAEVEKL--------RAAQMSSQGVEPE 617

  Fly   565 PRKIIIETSVDETEVEALRQQLAERERELSRAQKSWMEKLKEAEDQRKSELRVLKRRGLALELTA 629
            ..::.      :.|:.||:.:|.::|.|::.|.::|.|||:|||.:::.|.:.|:|.|:..::
Zfish   618 KMRLF------QQEIAALKNKLCQQEHEMAEAHRTWKEKLEEAERRKREEAKELQRAGVTFKV-- 674

  Fly   630 EQKQACLVNLTADPILSGTLFYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVALQHCSIEHER 694
            :.:...||||..||.||..|.|::.:|..::|:.:     |.|..||.|.|.|:|.|||.|...:
Zfish   675 DNRLPNLVNLNEDPQLSEMLLYMIKEGQTKVGKLK-----SESAHDIQLSGALIADQHCVISSVK 734

  Fly   695 GG-KLYVIPGSEDFETYVNGELLKDRRQLFHGDRLVIGGSHYFRISNPFCSQRGK-------ADH 751
            |. .:..:|.:   :|:|||.|:.:...|.||||:::||.||||.::|...|.||       .|.
Zfish   735 GTVSIKPMPNA---KTFVNGHLVSECTVLHHGDRVILGGDHYFRFNHPAEVQSGKRASCWSSGDG 796

  Fly   752 PVDFQLAHQEILQKQEQQLRSEL-EAEKRA-------------------------------ALTK 784
            ..||:.|..|:|..|..||.:|: ||..:|                               ||.:
Zfish   797 HKDFEFAKNELLSAQRAQLEAEIQEARLKAKEEMMQGIQVAKEMAQKELSEQKSLYEIKIRALER 861

  Fly   785 IEQERAQHARDFE----------ERLQ----CLELEQFKYKCNSEM-LETERQALALAQQQEHTP 834
            ..:|.::..|:.|          |:||    .||.|...:|...:| .:..|||:|     :| .
Zfish   862 ELKEESERKREQELHKQRAASQIEQLQSVKTLLEKEVSSHKRRLQMEAQATRQAMA-----DH-D 920

  Fly   835 LRHEDAVST-PAQKSTILEDIQRI-------------MLNPSEESLHKTQLMVKEATQRCRQLDL 885
            :||...|:. .|:|..|.||:.:|             |..|..::: |..||::||.:...:|..
Zfish   921 VRHAKIVAALEAEKRKIAEDLAQIEMKRALKVTQTPKMAIPQWDAM-KLSLMIEEANKISGKLRK 984

  Fly   886 PLEFRQTQTPD---EFGLLRTVILILDKQRGLKAEWPTARLGVWLDLVRDNAEQQEKLNATTIFQ 947
            ...|.:.:..|   |.|..:..:.:.:.:.|:...|...:....|..:|:..:.:.......:|.
Zfish   985 HTVFSRHEAADKEVEGGDAQLQVQVQNTKLGISTFWSLEKFQSNLAAMREIEQGESASKDDDVFY 1049

  Fly   948 SVEVDWEPLDADLNETLSDTHNSSRIALNLSAMKDV------------------------LLNKP 988
            ....:|||   ||:.:.|.:..|.|.:.:|...:.:                        |:|||
Zfish  1050 DPNDEWEP---DLSASSSTSSFSRRRSRSLLKSRRISGRLYEIRVHPIQSLHCTPSQSTGLMNKP 1111

  Fly   989 LKRLLNASSSKSNTP--------------RQTSTPSPGSQL----------VHFTKRLLT--YDP 1027
            ..  |::|:|.|..|              |...:......|          ||...|.:|  |:.
Zfish  1112 PS--LHSSTSDSALPGICKDLIGSAVARLRSCQSADESESLADKLTLDLLSVHRAVRAITDLYED 1174

  Fly  1028 EEIPESQSSFTTLVQQELQIMQRS-----AQRLRRHCEAAL-------------LERENHQDNGV 1074
            .:....::.|....:.:..:::.:     |..:..|..:::             |:.|..:..|.
Zfish  1175 LDDDSEENLFACSTEAQTHLVKATSAVERAVFITMHWVSSITFGSITVSQRAEELKMEVKKIGGY 1239

  Fly  1075 LAVSLQEALARMDTVLNGMHTSLARAEATACVTSPTKT 1112
            |.:.:|..    |:.::.|.|. ||.....|:.:..||
Zfish  1240 LQLLIQGC----DSEISSMVTE-ARKRVAECMNAVFKT 1272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	189/409 (46%)
		KISc	120..525	CDD:214526	188/408 (46%)
		Kinesin_assoc	524..657	CDD:292801	43/132 (33%)
		FHA	634..740	CDD:238017	42/106 (40%)
kif14	XP_005170522.1	KISc	235..586	CDD:214526	188/408 (46%)
		KISc_KIF1A_KIF1B	236..586	CDD:276816	188/407 (46%)
		Kinesin_assoc	583..701	CDD:292801	44/133 (33%)
		FHA	681..778	CDD:238017	42/104 (40%)
		Prefoldin	806..878	CDD:298833	14/71 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581690
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0245
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	484	1.000	Inparanoid score	I1402
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123768at33208
OrthoFinder	1	1.000	-	-		FOG0006888
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_108291
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5465
SonicParanoid	1	1.000	-	-		X4992
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.790