Protein Alignment neb and KIF16B

DIOPT Version :10

• Sequence 1: NP_476817.1
• Gene: neb / 35293
• FlyBaseID: FBgn0004374
• Length: 1121
• Species: Drosophila melanogaster
• Sequence 2: XP_005260807.1
• Gene: KIF16B / 55614
• HGNCID: 15869
• Length: 1883
• Species: Homo sapiens
• Alignment Length: 1079
• Identity: 327/1079 - (30%)
• Similarity: 509/1079 - (47%)
• Gaps: 207/1079 - (19%)

  Fly   123 VAVRVRPLN------------ALECTRGQVTNVVQVHGNSNELTVQAGSSADASAGVTHFFSYDQ 175
            |||||||:|            .:|.::..:||          |.:..|.:.|:....|..|:||.
Human     6 VAVRVRPMNRREKDLEAKFIIQMEKSKTTITN----------LKIPEGGTGDSGRERTKTFTYDF 60

  Fly   176 VYYSCDPERKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDG 240
            .:||.|.:..::..|..||:.....::.:||||||||:||||||||||||:|||         :.
Human    61 SFYSADTKSPDYVSQEMVFKTLGTDVVKSAFEGYNACVFAYGQTGSGKSYTMMG---------NS 116

  Fly   241 GPPHDEAGIIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPI 305
            |    ::|:|||.|..||.||.......:.....||||.|||||::.|||
Human   117 G----DSGLIPRICEGLFSRINETTRWDEASFRTEVSYLEIYNERVRDLL--------------- 162

  Fly   306 QQQQQQQRPALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSI 370
             :::..:...|:|||||..||||.|||.|.|.:|..:...:..||..|.||:|.|||.|||||:|
Human   163 -RRKSSKTFNLRVREHPKEGPYVEDLSKHLVQNYGDVEELMDAGNINRTTAATGMNDVSSRSHAI 226

  Fly   371 FNIVLNLTDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINK 435
            |.|  ..|....|..:..:|            .|||.|||||||||...:|:.|.|::||.:|||
Human   227 FTI--KFTQAKFDSEMPCET------------VSKIHLVDLAGSERADATGATGVRLKEGGNINK 277

  Fly   436 SLLTLGKVIAALADSRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASI 500
            ||:|||.||:||||..:..||  ..:.....|||||:|||||||:::|||||||:|:||||||.:
Human   278 SLVTLGNVISALADLSQDAAN--TLAKKKQVFVPYRDSVLTWLLKDSLGGNSKTIMIATISPADV 340

  Fly   501 HADETLATLRYACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSLRNEYERQRRLSGNSNNPVP 565
            :..|||:|||||.:|::|:|:..:||..:.|:||:||||:.|||:|..:        ||
Human   341 NYGETLSTLRYANRAKNIINKPTINEDANVKLIRELRAEIARLKTLLAQ--------GN------ 391

  Fly   566 RKIIIETSVDETEVEALRQQLAERERELSRAQKSWMEKLKEAEDQRKSELRVLKRRGLALELTAE 630
             :|.:   :|.....::.::|.:.|..:....|.|..|..|.::..|.:...|::.|:.:.|.:|
Human   392 -QIAL---LDSPTALSMEEKLQQNEARVQELTKEWTNKWNETQNILKEQTLALRKEGIGVVLDSE 452

  Fly   631 QKQACLVNLTADPILSGTLFYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVALQHCSIEHERG 695
            ...  |:.:..|.:.:|.:.|.|.:|...:||     ..:|::.||||.|..:..:||..|: .|
Human   453 LPH--LIGIDDDLLSTGIILYHLKEGQTYVGR-----DDASTEQDIVLHGLDLESEHCIFEN-IG 509

  Fly   696 GKLYVIP--GSEDFETYVNGELLKDRRQLFHGDRLVIGGSHYFRISNP----FCSQRGKADHPVD 754
            |.:.:||  ||   :..|||..:.:...|..|..:::|.::.||.::|    ...::.|:.....
Human   510 GTVTLIPLSGS---QCSVNGVQIVEATHLNQGAVILLGRTNMFRFNHPKEAAKLREKRKSGLLSS 571

  Fly   755 FQLAHQEILQKQEQQ------------------LRSELEAEKRAALTKIEQERAQHARDFEERLQ 801
            |.|:..::.:.:|..                  ||.|.|.::|..|.|:|.:| :...:.||:.:
Human   572 FSLSMTDLSKSRENLSAVMLYNPGLFPIKGPICLRLEFERQQREELEKLESKR-KLIEEMEEKQK 635

  Fly   802 C--LELEQFKYKCNSEMLETERQALALAQQQE-------HTPLRHEDAVSTPAQKSTI----LED 853
            .  .|||:.:.:..::..|||...|.:.:|:|       |...:.:|.:   |:|...    |.:
Human   636 SDKAELERMQQEVETQRKETEIVQLQIRKQEESLKRRSFHIENKLKDLL---AEKEKFEEERLRE 697

  Fly   854 IQRIMLNPSEESLHKTQLMVKEATQRCRQLD-----------LPLEFRQTQTPDEFGLLRTVILI 907
            .|.|.|....:. .:|.|.|:|..||.::|:           ..|:..|.:..:::..|.
Human   698 QQEIELQKKRQE-EETFLRVQEELQRLKELNNNEKAEKFQIFQELDQLQKEKDEQYAKLE----- 756

  Fly   908 LDKQRGLKAEWPTARLGVWLDLVRDNAEQ-QEKLNATTIFQSVEVDW---EPLDAD-LNETL--- 964
            |:|:|..:.|.....|...|:      || :||.....:.:..||.|   |..|.: :.|:|
Human   757 LEKKRLEEQEKEQVMLVAHLE------EQLREKQEMIQLLRRGEVQWVEEEKRDLEGIRESLLRV 815

  Fly   965 --------SDTHNSSRIALNLSAMKDVLLNKPLKRLLNAS----SSKSNTPRQTSTPSPGSQLVH 1017
                    .|.....:..|.....|    .:.|.:|:|..    ..|....::....   .:::.
Human   816 KEARAGGDEDGEELEKAQLRFFEFK----RRQLVKLVNLEKDLVQQKDILKKEVQEE---QEILE 873

  Fly  1018 FTK-------RLL------TYDPEEIPESQSSFTTLVQQELQIMQRSAQRLRRHCEAALLERENH 1069
            ..|       |||      ..|..|:|:....... |:..||..:|..|.|.::....|||.:..
Human   874 CLKCEHDKESRLLEKHDESVTDVTEVPQDFEKIKP-VEYRLQYKERQLQYLLQNHLPTLLEEKQR 937

  Fly  1070 Q----DNGVLAVSLQEALARMDTVLNGMHTSLARAEATA 1104
            .    |.|.|  ||...|.:::..:......||:.:|.|
Human   938 AFEILDRGPL--SLDNTLYQVEKEMEEKEEQLAQYQANA 974

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	175/413 (42%)
		SMC_N	514..>615	CDD:481474	27/100 (27%)
		FHA_KIF14	627..741	CDD:438759	33/115 (29%)
KIF16B	XP_005260807.1	KISc_KIF1A_KIF1B	2..365	CDD:276816	175/413 (42%)
		Kinesin_assoc	364..476	CDD:465047	33/131 (25%)
		FHA_KIF16B	446..562	CDD:438784	34/126 (27%)
		Smc	<606..>1089	CDD:440809	87/395 (22%)