Protein Alignment neb and kif3a

DIOPT Version :10

• Sequence 1: NP_476817.1
• Gene: neb / 35293
• FlyBaseID: FBgn0004374
• Length: 1121
• Species: Drosophila melanogaster
• Sequence 2: NP_001017604.2
• Gene: kif3a / 550267
• ZFINID: ZDB-GENE-050417-71
• Length: 701
• Species: Danio rerio
• Alignment Length: 909
• Identity: 254/909 - (27%)
• Similarity: 397/909 - (43%)
• Gaps: 240/909 - (26%)

  Fly   113 LSVSEESNMIVAVRVRPLNALECTRG--QVTNVVQVHGNSNELTVQAGSSADASAGVTHFFSYDQ 175
            |.||:  |:.|.||.||||..|...|  |...|.::.|.   :||   :..|.|:.....|::|.
Zfish    12 LEVSD--NVKVVVRCRPLNEKEKIMGHKQSVTVDEIRGT---ITV---NKLDISSEPPKTFTFDT 68

  Fly   176 VYYSCDPERKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDG 240
            |:   .|:.|    |..|:..||||:||:..||||..:|||||||:||:::|.|:.|:.:.
Zfish    69 VF---GPDSK----QLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAVPEL---- 122

  Fly   241 GPPHDEAGIIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPI 305
                  .||||.....:|..|  .|::...:..|.|||.|||||::.|||.
Zfish   123 ------RGIIPNSFAHVFGHI--AKAEGDTRFLVRVSYLEIYNEEVRDLLG-------------- 165

  Fly   306 QQQQQQQRPALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSI 370
              :.|.||  |:|:|.|..|.|:.|||.:.|::...:...:.:|:..|:..:|.||:.|||||:|
Zfish   166 --KDQMQR--LEVKERPDVGVYIKDLSGYVVNNADDMDRIMTLGHKNRSVGATNMNEHSSRSHAI 226

  Fly   371 FNIVLNLTDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINK 435
            |.|.:..::...|..             :..|..|:.|||||||||...:|:.|:|::|...||.
Zfish   227 FTITIECSEKGVDGN-------------QHVRMGKLHLVDLAGSERQGKTGATGQRLKEATKINL 278

  Fly   436 SLLTLGKVIAALADSRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASI 500
            ||.|||.||:||.|.:             ||.||||.|.||.||:::|||||||:|.|.|.||..
Zfish   279 SLSTLGNVISALVDGK-------------STHVPYRNSKLTRLLQDSLGGNSKTMMCANIGPADY 330

  Fly   501 HADETLATLRYACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSLRNEYERQRRLSGNSNNPVP 565
            :.|||::|||||.:|::|.|:.::||.|.|.::|..:.|::.||   .:.|....:||:..:.
Zfish   331 NYDETISTLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELK---KKLEEGEEISGSDGSG-- 390

  Fly   566 RKIIIETSVDETEVEALRQQLAERERELSRAQKSWMEKLKEAEDQRKSELRVLKRRGLALELTAE 630
                 ...:||.:|    ....||.|:....:|...:|:.|.:.:.:.|     |:.|..:|..|
Zfish   391 -----SDDMDEDDV----GDGGERRRKRRGRKKVSPDKMVEMQAKIEEE-----RKALEAKLDME 441

  Fly   631 QKQACLVNLTADPILSGTLFYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVALQHCSIEHERG 695
            :::                            |.:........:.|:     |.|.|    ||
Zfish   442 EEE----------------------------RNKARAELEKREKDL-----LKAQQ----EH--- 466

  Fly   696 GKLYVIPGSEDFETYVNGELLKDRRQLFHGDRLVIGGSHYFRISNPFCSQRGKADHPVDFQLAHQ 760
                              .||.::..... .|:::||                    ||. ||..
Zfish   467 ------------------HLLLEKLSALE-KRVIVGG--------------------VDL-LAKA 491

  Fly   761 EILQKQEQQLRSELEAEKRAA--LTKIEQERAQHARDFEERLQCLELE-QFKYKCNSE---MLET 819
            |..:|..::..:|||..::.|  |.:..:|:.|...|.||:...|:.| |.|.|...:   ||..
Zfish   492 EEQEKLLEESNNELEERRKRAEQLRRELEEKEQERLDIEEKYTSLQEEAQGKTKKLKKVWTMLMA 556

  Fly   820 ERQALALAQQQEHTPLRHEDAVSTPAQKSTILEDIQRIMLNPSEESLHKTQLMVKEATQRCRQLD 884
            .:..:|..||:.|..:            ..:||:|:::    |.|.  :.|:::         :|
Zfish   557 AKSEMADLQQEHHREI------------EGLLENIRQL----SREL--RLQMLI---------ID 594

  Fly   885 --LPLEFRQTQTPDEFGLLRTVILILDKQRGLKAEWPTARLGVW-LDLVRDNAEQQEKLNATTIF 946
              :|.|:::        ::...:           .| ...:|.| |..|........|  .|.:.
Zfish   595 NFIPQEYQE--------MIENYV-----------HW-NEDIGEWQLKCVAYTGNNMRK--QTPVS 637

  Fly   947 QSVEVDWEPLDADLNET-LSDTHNSSRIALNLSAMKDVLLNKPLKRLLNASSSKSNTPRQTSTP 1009
            ...|.|  |.:.||:.. |:.|..|.|.:|    ||   |.:|.......|..|:...:::|.|
Zfish   638 DKKEKD--PFEVDLSHVYLAYTEESMRQSL----MK---LERPRTSKNGKSRPKTGRRKRSSKP 692

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	153/407 (38%)
		SMC_N	514..>615	CDD:481474	23/100 (23%)
		FHA_KIF14	627..741	CDD:438759	14/113 (12%)
kif3a	NP_001017604.2	KISc_KIF3	16..348	CDD:276822	151/402 (38%)
		Smc	<424..>589	CDD:440809	49/267 (18%)