Protein Alignment neb and kif11

DIOPT Version :10

• Sequence 1: NP_476817.1
• Gene: neb / 35293
• FlyBaseID: FBgn0004374
• Length: 1121
• Species: Drosophila melanogaster
• Sequence 2: NP_001016116.2
• Gene: kif11 / 548870
• XenbaseID: XB-GENE-978999
• Length: 1067
• Species: Xenopus tropicalis
• Alignment Length: 1133
• Identity: 287/1133 - (25%)
• Similarity: 467/1133 - (41%)
• Gaps: 307/1133 - (27%)

  Fly   120 NMIVAVRVRPLNALECTRGQVTNVVQVHGNSNELTVQAGSSADASAGVTHFFSYDQVYYSCDPER 184
            |:.|.||.||.|.|| .:....:|::......|:.|:.|...|.....|  :::|.|:   .|..
 Frog    18 NIQVVVRCRPFNQLE-RKASSHSVLECDAPRKEVCVRTGGINDKLGKKT--YTFDMVF---GPAA 76

  Fly   185 KNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGPPHDEAGI 249
            |    |..|:.....|::|....|||..:|||||||:||:::|.|..:.|:.......|  .|||
 Frog    77 K----QIDVYRSVVCPILDEVIMGYNCTVFAYGQTGTGKTFTMEGERSADEEFTWEQDP--LAGI 135

  Fly   250 IPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQQQQRP 314
            |||..|::|.::    |:...:..|:||..|||||::.||||   .:...||...:....:.:|.
 Frog   136 IPRTLHQIFEKL----SENGTEFSVKVSLLEIYNEELFDLLS---PSPDVGERLQMFDDPRNKRG 193

  Fly   315 ALKVREHPIFGPYVVDLSAHSVDS-YSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNIVLNLT 378
            .:      |.|  :.::|.|:.|. |..|..    |.::|.||||.||..||||||:|::.:::.
 Frog   194 VI------IKG--LEEVSVHNKDEVYHILER----GAARRKTASTLMNAYSSRSHSVFSVTIHMK 246

  Fly   379 DLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINKSLLTLGKV 443
            :             :|.......:..|::||||||||.|..||:..:|.||..:||:||||||:|
 Frog   247 E-------------TTVDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRV 298

  Fly   444 IAALADSRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASIHADETLAT 508
            |.||.:.              :..:|||||.||.:|:::|||.:||.::||:|||||:.:||::|
 Frog   299 ITALVER--------------APHIPYRESKLTRILQDSLGGRTKTSIIATVSPASINLEETVST 349

  Fly   509 LRYACKARSIVNRVKVNESPHDK-IIRDLRAEVDRLKS------------LRNE-YERQRRLSGN 559
            |.||.:|::|:|:.:||:....: :|::...|::|||.            |.|| ||   :|.|.
 Frog   350 LEYANRAKNIMNKPEVNQKLTKRALIKEYTEEIERLKRDLATAREKNGVYLSNENYE---QLQGK 411

  Fly   560 --SNNPVPRKIIIETSVDETEVEALRQQLAERERELSRAQKSWMEKLKEAEDQRKSELRVLKRRG 622
              |...:..:...:.:..|.|::.:.:..||.::||.........|.||.|:.:|:
 Frog   412 VLSQEEIITEYTEKITAMEEEIKRINELFAENKKELEECTTILQCKEKELEETQKN--------- 467

  Fly   623 LALELTAEQ--KQACLVNL--TADPILSGTLFYLLPQGLVRIGRGRLPGGSSSSQPDI-----VL 678
              |..:.||  ::|.:|..  |.:..|.||...||.  .||           .:..|:     .|
 Frog   468 --LHESKEQLAQEAFVVTALETTEKKLHGTANKLLT--TVR-----------ETSKDVSGLHAKL 517

  Fly   679 DGPLVALQHCSIEHER-----GGKLYVIPGSEDFETYVNGELLKDRRQLFHGDRL--VIGGSH-- 734
            |......||.:..||.     ..:..||..|.| |..|..:.:.|    |:.:.:  ::|.|.
 Frog   518 DRKRAVDQHNTQVHENFAEQMNKRFSVIERSVD-EYSVKQQGMLD----FYTNSIDDLLGASSAA 577

  Fly   735 ----YFRISNPFCSQR----GKADHPVDFQLAHQEILQKQ----------------EQQLRSELE 775
                ...::..|.|.:    .|..|.|| ::..||.|..|                ||.||::|.
 Frog   578 LSVTATAVAKSFTSVQETVSEKVSHSVD-EILKQETLSSQAKDDLQKLMAAHRTGLEQALRTDLL 641

  Fly   776 AEKRAALT-----------------KIEQER-------AQHAR-------DFEERLQCLELEQFK 809
            ....|.|.                 ||:..:       .:|:|       |....|..::.|...
 Frog   642 PVVTAVLNLNSHLSHCLQNFQAVADKIDSHKEEMNSFFTEHSRSLHRLRLDSGSALSSIQSEYES 706

  Fly   810 YKCNSE---------------MLETERQALALAQQQ----------------------------- 830
            .|...|               .|:.:...||:..||
 Frog   707 LKVEIETAQSMHSEGVNNLIGSLQNQLNLLAMETQQNFSGFLAKGGKLQKSVGCLQQDLDSISSD 771

  Fly   831 --EHTPLRHEDAVSTPAQKSTILEDIQRIM---LNPSEESLHKTQLMV-------KEATQRC--- 880
              |||...|:   ....|...|..:|:::.   :...|||..:.:.:.       :|:...|
 Frog   772 AIEHTSSHHD---KFAGQSQDIAVEIRQLAASNMGTLEESSKQCEKLTGSINAISRESQHWCESA 833

  Fly   881 -RQLDLPLEFRQTQTPDEFGLLRTVILILDKQRGLKAEWPTARLGVWLDLV----RDNAEQQ-EK 939
             :|:|..||       ::...|||      .::.|::......:|....:|    ..||::| |:
 Frog   834 SQQIDSLLE-------EQVCYLRT------SKKHLQSLQKDVEVGCGASVVEITEHVNAQRQAEE 885

  Fly   940 LNATTIFQSVEVDWEPLD---ADLNETLSDTHNSSRIALNLSAMKDVLLNKPLKRLLNASSSKSN 1001
            ...|::.:.|..|.|.|.   .:|:|.:....|.....||.....||              ....
 Frog   886 KALTSLVEQVRDDKEMLGEQRLELHEQVQSGQNKVNSYLNEELRNDV--------------PTGT 936

  Fly  1002 TPRQTSTPSPGSQLVHFTKRLLTYDPEEIPESQSSFTTLVQQELQIMQRSAQRLRRHCEAAL--- 1063
            ||::.....| |.||. ||      |.::         |::|..|..|...:.:......|:
 Frog   937 TPQRRDYVYP-SLLVR-TK------PRDV---------LLEQFRQQQQEYLESISSVISEAVEPP 984

  Fly  1064 LERENHQDNGVLAVSLQEALARMDTVLN 1091
            :|:::.:|...:||:        |:|::
 Frog   985 VEQDSLEDEPPVAVN--------DSVMS 1004

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	142/405 (35%)
		SMC_N	514..>615	CDD:481474	29/116 (25%)
		FHA_KIF14	627..741	CDD:438759	29/135 (21%)
kif11	NP_001016116.2	KISc_BimC_Eg5	16..368	CDD:276815	144/407 (35%)
		SMC_prok_B	376..>635	CDD:274008	64/291 (22%)
		sbcc	406..>915	CDD:129705	109/557 (20%)
		Microtub_bind	927..1066	CDD:464048	22/117 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1048..1067