DRSC/TRiP Functional Genomics Resources

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Protein Alignment neb and KIF1A

DIOPT Version :10

Sequence 1:NP_476817.1 Gene:neb / 35293 FlyBaseID:FBgn0004374 Length:1121 Species:Drosophila melanogaster
Sequence 2:XP_047300774.1 Gene:KIF1A / 547 HGNCID:888 Length:1825 Species:Homo sapiens


Alignment Length:935 Identity:293/935 - (31%)
Similarity:458/935 - (48%) Gaps:193/935 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   123 VAVRVRPLNALECTRGQVTNVVQVHGNSNELTVQAGSSADASAGVTHFFSYDQVYYS-CDPERKN 186
            |||||||.|:.|.:|.... ::|:.|::..:.     :..........||:|..|:| ..||..|
Human     8 VAVRVRPFNSREMSRDSKC-IIQMSGSTTTIV-----NPKQPKETPKSFSFDYSYWSHTSPEDIN 66

  Fly   187 FACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGPPHDEAGIIP 251
            :|.|.:|:......::..||||||.|:|||||||:||||:|||.:           ..|:.||||
Human    67 YASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQ-----------EKDQQGIIP 120

  Fly   252 RFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQQQQRPAL 316
            :.|.:||.||... :...:...|||||.|||.|::.|||:                  .:.:..|
Human   121 QLCEDLFSRINDT-TNDNMSYSVEVSYMEIYCERVRDLLN------------------PKNKGNL 166

  Fly   317 KVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNIVLNLTDLS 381
            :|||||:.||||.|||..:|.||:.:::.:..||..|..|:|.||:.|||||::|||:  .|...
Human   167 RVREHPLLGPYVEDLSKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNII--FTQKR 229

  Fly   382 SDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINKSLLTLGKVIAA 446
            .|    ::|:.:|      .:.|||||||||||||...:|:.|.|::||.:|||||.||||||:|
Human   230 HD----AETNITT------EKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISA 284

  Fly   447 LADSRKAIANGPLGS--GTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASIHADETLATL 509
            ||:    :.:||..:  ...:.|:|||:|||||||||||||||:|.|:|.:|||.|:.||||:||
Human   285 LAE----MDSGPNKNKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTL 345

  Fly   510 RYACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSLR---------------------NEYERQ 553
            |||.:|:.|.....:||.|::|:||:|:.||.||:.|.                     ::.|..
Human   346 RYADRAKQIRCNAVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDITDTNTVPGGPKYVSDLENN 410

  Fly   554 RRLSGNSNNPVPRKIIIETSV-----DETEVEALR-----------------------QQLAERE 590
            ....|.:.|..|..:...|:.     ..:.:.||.                       ::|.|.|
Human   411 NLNRGGTVNEAPDPLSTVTNALVGMSPSSSLSALSSRAASVSSLHERILFAPGSEEAIERLKETE 475

  Fly   591 RELSRAQKSWMEKLKEAEDQRKSELRVLKRRGLA-------LELTAEQKQACLVNLTADPILSGT 648
            :.::...::|.|||:..|..|.....:|...|:|       |.:.:.:|...||||..||::|..
Human   476 KIIAELNETWEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSEC 540

  Fly   649 LFYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVALQHCSIEHE-RGGK--LYVIPGSEDFETY 710
            |.|.:..|:.|:||     .....:.||||.|..:..:||....: |||.  :..:...|..:||
Human   541 LLYYIKDGITRVGR-----EDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTY 600

  Fly   711 VNGELLKDRRQLFHGDRLVIGGSHYFRISNPFCSQRGK--------ADHPVDFQLAHQEILQKQE 767
            |||:.:.:...|..|:|:::|.||.||.::|..:::.:        ...|||:..|.:|:|:||.
Human   601 VNGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERERTPCAETPAEPVDWAFAQRELLEKQG 665

  Fly   768 QQLRSELEAEKRAALTKIEQERAQHARDFEERLQCLELEQFKYKCNSEMLETERQALALAQ--QQ 830
            ..::.|:|       .::::...|:.|:.||....||.::..|:...|.|:.:..:....:  ::
Human   666 IDMKQEME-------QRLQELEDQYRREREEATYLLEQQRLDYESKLEALQKQMDSRYYPEVNEE 723

  Fly   831 EHTPLRHEDAVSTPAQKS---------------TILEDIQRIMLNPSEESLHKTQLMVKEATQRC 880
            |..|   ||.|....::.               |.|.|:           |....:.:|||....
Human   724 EEEP---EDEVQWTERECELALWAFRKWKWYQFTSLRDL-----------LWGNAIFLKEANAIS 774

  Fly   881 RQLDLPLEFR---QTQT------PDEFGLL--------------RTVIL--ILDKQRGLKAEWPT 920
            .:|...::|:   .|.|      ||   ||              ||::.  :.|::.|....|..
Human   775 VELKKKVQFQFVLLTDTLYSPLPPD---LLPPEAAKDRETRPFPRTIVAVEVQDQKNGATHYWTL 836

  Fly   921 ARLGVWLDLVRDNAEQQEKLNATTI 945
            .:|...|||:|:..::..::.::.|
Human   837 EKLRQRLDLMREMYDRAAEVPSSVI 861

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nebNP_476817.1 KISc_KIF1A_KIF1B 119..525 CDD:276816 172/404 (43%)
SMC_N 514..>615 CDD:481474 30/149 (20%)
FHA_KIF14 627..741 CDD:438759 38/116 (33%)
KIF1AXP_047300774.1 KISc_KIF1A_KIF1B 4..361 CDD:276816 172/404 (43%)
Kinesin_assoc 358..549 CDD:465047 42/190 (22%)
FHA_KIF1A 525..639 CDD:438778 38/118 (32%)
ERM_helical 658..>711 CDD:466641 15/59 (25%)
KIF1B 839..886 CDD:463574 6/23 (26%)
DUF3694 1275..1431 CDD:463599
PH_KIFIA_KIFIB 1706..1808 CDD:269939
Blue background indicates that the domain is not in the aligned region.

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