DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment neb and Klp98A

DIOPT Version :9

Sequence 1:	NP_476817.1	Gene:	neb / 35293	FlyBaseID:	FBgn0004374	Length:	1121	Species:	Drosophila melanogaster
Sequence 2:	NP_524532.2	Gene:	Klp98A / 43310	FlyBaseID:	FBgn0004387	Length:	1265	Species:	Drosophila melanogaster

Alignment Length:	1043	Identity:	319/1043 - (30%)
Similarity:	497/1043 - (47%)	Gaps:	201/1043 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 SNMIVAVRVRPLNALECTRGQVTNVVQVHGNSNELTVQAGSSADASAGVTHFFSYDQVYYSCDPE 183
            |::.|||||||.|:.|........:...:..:..|..:..|..||.....|.|::|..|:|.|.|
  Fly     2 SSLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSFDAE 66

  Fly   184 RKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGPPHDEAG 248
            ..:||.|.:|:......::|.|:||||||:||||||||||:::|||..             :..|
  Fly    67 DPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTP-------------NNPG 118

  Fly   249 IIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQQQQR 313
            :|||.|.|||.|:. |..:.........||.|||||::.|||    ||.:||.
  Fly   119 LIPRICEELFARMR-VGQESGTGYRTHASYLEIYNERVKDLL----AAQSTGH------------ 166

  Fly   314 PALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNIVLNLT 378
             .|:||||...||||.:||.|:|..:..::..:|.||:||.||||.|||.|||||:||.|.....
  Fly   167 -GLRVREHRSLGPYVENLSQHAVSDFDEIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQA 230

  Fly   379 DLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINKSLLTLGKV 443
            ...:|  :.|:|            .|||.|||||||||.:.:|:.|:|::||..|||||:|||.|
  Fly   231 VFMND--MPSET------------VSKIHLVDLAGSERANATGATGQRLKEGAHINKSLVTLGSV 281

  Fly   444 IAALAD--------SRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASI 500
            |:|||:        |..|:|..|.|:.....::|||:|:|||||:::|||||||:|:|.:|||..
  Fly   282 ISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSILTWLLKDSLGGNSKTIMIAALSPADC 346

  Fly   501 HADETLATLRYACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSLRNEYERQRRLSGNSNNPVP 565
            :..|||:|||||.:|::|:|:..|||..:.|:||:||.|:::|||:         |:|:.::..|
  Fly   347 NYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELREEINKLKSM---------LAGDIHSLQP 402

  Fly   566 R-KIIIETSVDETEVEALRQQLAERERELSRAQKSWMEKLKEAED--QRKSELRVLKRRGLALEL 627
            . |::.:....|.:.:.|.::              |.||.|.|:.  |.:..|. |::.|:.:.|
  Fly   403 SLKVLADLQKKEAQEKVLTEE--------------WTEKWKVAQSILQEQKSLG-LRKSGVGVVL 452

  Fly   628 TAEQKQACLVNLTADPILSGTLFYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVALQHCSIEH 692
            .:|...  |:.:..| :.:|...|.|.:|..|||     ...:....||.|.|..:..||||| .
  Fly   453 DSEMPH--LIGIHND-VTTGVTLYSLKEGETRIG-----SEDADVAQDIELAGDGIRAQHCSI-F 508

  Fly   693 ERGGKLYVIPGSEDFETYVNGELLKDRRQLFHGDRLVIGGSHYFRISNPFCSQRGKADHPVDFQL 757
            .:||.:.:.|... .:.:||..|:.:.:|:..||.:::|.::.||.:||..:.:.:.|      |
  Fly   509 LKGGVVTLHPWPL-AQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLRKD------L 566

  Fly   758 AHQE--------ILQKQEQQLRSELEAEKRAALTKIEQERAQH-----ARDFEERLQCLELEQFK 809
            :..:        |...:|..|...:.:::..|......||..:     :||..|    |:.|
  Fly   567 SRSQLDMSRLSLITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPMSRDDPE----LQDE--- 624

  Fly   810 YKCNSEMLETERQALALAQQQEHTPLRHEDAVSTPAQKSTILEDIQRI---------MLNPSEES 865
               |.::|:|...||   :|.....::..|...|..:|.|  |::.|:         :||..|:.
  Fly   625 ---NRKILDTIENAL---KQLNVERVQMHDQYKTKVRKLT--EELIRLEQEEMDGLQLLNCREQE 681

  Fly   866 L--HKTQLMVKEATQR------CRQLDLPLEFRQTQTPDEFGLLRTVILILDKQRGLKAEWPTAR 922
            |  .|..|:.::..::      |||:..    .|||              ||.::...:|:....
  Fly   682 LIARKDMLLWEKNNEKVQIDIVCRQISA----FQTQ--------------LDSKKRDFSEYVAKE 728

  Fly   923 LGVW-----LDLVRDNAEQQEKLNATTIFQSVEVDWEPLDADLNETLSDT--HNSSRIALNLSAM 980
            |...     ||.:....|:...||...:.|..    :.||....:.:.||  .|:..|    ..:
  Fly   729 LQELQDCGKLDEMGMKIEEGTPLNDELLLQVS----DSLDLFAAQFIKDTVRRNNEEI----RKL 785

  Fly   981 KDVLLNKPLKRLLNASSSKSNTPRQTSTPSPGSQLVHFTKRLLTYDPEEIPESQSSFTTLVQQEL 1045
            .:.:..|  :|:||||::|.....:|..... :||    :||.....|...|||:........:|
  Fly   786 DEQIAEK--ERILNASTTKIAKVDETMLEIQ-AQL----ERLRLERAESEAESQAMRAKKQNMKL 843

  Fly  1046 QIMQRSAQRLRRHCEAALLERENHQDNGVLAVSLQEALARMDTVLNGMHTSLARAEATACVTSPT 1110
            |:..:|         .:.....|..|:    ||..:.....||    .||:.:.   .:.|:|||
  Fly   844 QLGNKS---------MSTSTSTNEADD----VSKSDTYETCDT----FHTAQSN---LSLVSSPT 888

  Fly  1111 KTQ 1113
            .|:
  Fly   889 ITE 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	173/413 (42%)
		KISc	120..525	CDD:214526	172/412 (42%)
		Kinesin_assoc	524..657	CDD:292801	34/135 (25%)
		FHA	634..740	CDD:238017	30/105 (29%)
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	173/413 (42%)
		KISc	3..371	CDD:214526	172/412 (42%)
		Kinesin_assoc	370..478	CDD:292801	34/134 (25%)
		FHA	456..555	CDD:238017	30/108 (28%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437734
Domainoid	1	1.000	252	1.000	Domainoid score	I517
eggNOG	1	0.900	-	-		E2759_KOG0245
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123768at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850