DRSC/TRiP Functional Genomics Resources

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Protein Alignment neb and KIF3C

DIOPT Version :10

Sequence 1:NP_476817.1 Gene:neb / 35293 FlyBaseID:FBgn0004374 Length:1121 Species:Drosophila melanogaster
Sequence 2:NP_002245.4 Gene:KIF3C / 3797 HGNCID:6321 Length:793 Species:Homo sapiens


Alignment Length:847 Identity:229/847 - (27%)
Similarity:355/847 - (41%) Gaps:274/847 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   100 SRTKERDSLMESCLSVSEESNMIVAVRVRPLNALECTRGQVTNVVQVHGNSNELTVQAGSSADAS 164
            |:||..::|.             |..|.|||:..|...|. ..::.:.....::|::...:|...
Human     3 SKTKASEALK-------------VVARCRPLSRKEEAAGH-EQILTMDVKLGQVTLRNPRAAPGE 53

  Fly   165 AGVTHFFSYDQVYYSCDPERKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMG 229
            ...|  |::|.||   |...|    ||.:::.|.|||||:..:|:|..:|||||||:||:|:|.|
Human    54 LPKT--FTFDAVY---DASSK----QADLYDETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTMQG 109

  Fly   230 --IEALDDAALDGGPPHDEAGIIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSV 292
              :|.            :..|:||.....:|..|...::||.|   |..||.|||.|:|.|||| 
Human   110 TWVEP------------ELRGVIPNAFEHIFTHISRSQNQQYL---VRASYLEIYQEEIRDLLS- 158

  Fly   293 QHAAAATGESTPIQQQQQQQRPALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATAS 357
                             ::....|:::|:|..|.|:.|||:....:...:.:.:.:||..||..|
Human   159 -----------------KEPGKRLELKENPETGVYIKDLSSFVTKNVKEIEHVMNLGNQTRAVGS 206

  Fly   358 TAMNDKSSRSHSIFNIVLNLTDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGS 422
            |.||:.|||||:||.|.:..::..||   ..|          ..|..|::|||||||||.:.:|.
Human   207 THMNEVSSRSHAIFIITVECSERGSD---GQD----------HIRVGKLNLVDLAGSERQNKAGP 258

  Fly   423 N------------------------GERIREGVSINKSLLTLGKVIAALADSRKAIANGPLGSGT 463
            |                        |||.:|...||.||..||.||||||.:|            
Human   259 NTAGGAATPSSGGGGGGGGSGGGAGGERPKEASKINLSLSALGNVIAALAGNR------------ 311

  Fly   464 PSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASIHADETLATLRYACKARSIVNRVKVNESP 528
             ||.:|||:|.||.||:::||||:||:|:||:.|||...||:|:|||:|.:|::|.|:.:|||.|
Human   312 -STHIPYRDSKLTRLLQDSLGGNAKTIMVATLGPASHSYDESLSTLRFANRAKNIKNKPRVNEDP 375

  Fly   529 HDKIIRDLRAEVDRLKS------------LRNEYERQRRLSG--------------------NSN 561
            .|.::|:.:.|:.|||:            .|....|::.:|.                    |:|
Human   376 KDTLLREFQEEIARLKAQLEKRGMLGKRPRRKSSRRKKAVSAPPGYPEGPVIEAWVAEEEDDNNN 440

  Fly   562 NPVPRKIIIETSVDETEVEALRQQLAERERELSRAQ--KSWM--EKLKEAEDQRKSELRVLKRRG 622
            |..|.:.|:|:::::.....|::|....|.|.:..|  :|.:  ||.|..|::.|. |..|:|..
Human   441 NHRPPQPILESALEKNMENYLQEQKERLEEEKAAIQDDRSLVSEEKQKLLEEKEKM-LEDLRREQ 504

  Fly   623 LALELTAEQKQACLVNLTADPILSGTLFYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVALQH 687
            .|.||.|.:.:|.                                                    
Human   505 QATELLAAKYKAM---------------------------------------------------- 517

  Fly   688 CSIEHERGGKLYVIPGSEDFETYVNGELLKDRRQLFHGDRLVIGGSHYFRISNPFCSQRGKADHP 752
                                                 ..:|:|||             |...||.
Human   518 -------------------------------------ESKLLIGG-------------RNIMDHT 532

  Fly   753 VD----FQLAHQEILQ--------KQEQQLRSELEAEKRAALTKIEQE---RAQHARDFEERLQC 802
            .:    .:|..|||.:        :||..||.|...|.|...|.::||   :.:..:....:||.
Human   533 NEQQKMLELKRQEIAEQKRREREMQQEMMLRDEETMELRGTYTSLQQEVEVKTKKLKKLYAKLQA 597

  Fly   803 LELE-QFKYKCNSEMLETERQALALAQQQEHTPLRHE----DAVSTPAQKSTILEDIQRIMLNPS 862
            ::.| |.::   .|.:.. ||.|..||.::...|:.:    :....|.:|:.|:   .|:.|:..
Human   598 VKAEIQDQH---DEYIRV-RQDLEEAQNEQTRELKLKYLIIENFIPPEEKNKIM---NRLFLDCE 655

  Fly   863 EE 864
            ||
Human   656 EE 657

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nebNP_476817.1 KISc_KIF1A_KIF1B 119..525 CDD:276816 148/431 (34%)
SMC_N 514..>615 CDD:481474 33/136 (24%)
FHA_KIF14 627..741 CDD:438759 7/113 (6%)
KIF3CNP_002245.4 KISc_KIF3 9..365 CDD:276822 147/437 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 251..288 7/36 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 394..424 3/29 (10%)
Smc <452..>635 CDD:440809 51/289 (18%)
Globular. /evidence=ECO:0000255 630..793 7/31 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 750..793
Blue background indicates that the domain is not in the aligned region.

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