DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment neb and Cenpe

DIOPT Version :9

Sequence 1:	NP_476817.1	Gene:	neb / 35293	FlyBaseID:	FBgn0004374	Length:	1121	Species:	Drosophila melanogaster
Sequence 2:	XP_038959788.1	Gene:	Cenpe / 362044	RGDID:	1307115	Length:	2456	Species:	Rattus norvegicus

Alignment Length:	1069	Identity:	282/1069 - (26%)
Similarity:	455/1069 - (42%)	Gaps:	269/1069 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 VSEESNMIVAVRVRPLNALECTRGQVTNVVQVHGNSNELTVQAGSSADASAGVTHFFSYDQVYYS 179
            ::||:.:.|.|||||||:.|...|:.:::......:.......|.|          |.:|:|::|
  Rat     1 MAEEAAVAVCVRVRPLNSREEELGEASHIYWKTDKNAIYQSDGGKS----------FQFDRVFHS 55

  Fly   180 CDPERKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGPPH 244
             :...||      |:|..|.|:|.:|.:|||..:||||||.|||:::|||.|
  Rat    56 -NETTKN------VYEEIAVPIISSAIQGYNGTIFAYGQTASGKTHTMMGSE------------- 100

  Fly   245 DEAGIIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQ 309
            |..|:|||..|::|:||:....::.|   :.|||.|||||.|.|||.                ..
  Rat   101 DCLGVIPRAIHDIFQRIKKFPEREFL---LRVSYMEIYNETITDLLC----------------NT 146

  Fly   310 QQQRPALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNIV 374
            |:.:| |.:||......||.||:...|.:......|||.|...|....|.||.:|||||:||.::
  Rat   147 QKVKP-LIIREDINRNVYVADLTEEVVYTAEMALKWLATGEKNRHYGITKMNQRSSRSHTIFRMI 210

  Fly   375 LNLTDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINKSLLT 439
            |.    |.:...||:.|.|       .:.|.::|||||||||.:.:|:.|.|::||..||::||.
  Rat   211 LE----SREKAESSNCDGS-------IKVSHLNLVDLAGSERAAQTGAEGMRLKEGCYINRNLLI 264

  Fly   440 LGKVIAALADSRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASIHADE 504
            ||:||..|:|       |.:|.     |:.||:|.||.:|:.:||||:||.::.||:|||:  ||
  Rat   265 LGQVIKKLSD-------GQVGG-----FINYRDSKLTRILQNSLGGNAKTRIICTITPASL--DE 315

  Fly   505 TLATLRYACKARSIVNRVKVNESPHDK-IIRDLRAEVDRLKSLRNEYERQRRLSGNSNNPVPRKI 568
            ||.||::|..|:.:.|...|||..:|: :::..|.|:..||....|                  :
  Rat   316 TLTTLQFASTAKYMKNTPYVNEVSNDEALLKRYRREIVDLKKQLEE------------------V 362

  Fly   569 IIETSVDETEVEALRQQLAERERELSRAQKSWMEKLK-----EAEDQRKSELRVLKRR------G 622
            ..:|...|.|.:.|.|.|.|::. |.:.|...::.||     .:....:.||.:.|:|      |
  Rat   363 NTKTRAQEIEKDQLAQLLDEKDL-LQKVQDEKIQNLKRMLVTSSSIALQQELEIKKKRRVTWCFG 426

  Fly   623 LALELTAEQKQACLVNLT-------ADPILSGTLFYLLPQGLVRIGRGRLPGGSSSSQPDIVLDG 680
            ...:....::.....|:|       ..|:...:|..|              |.|:.|....|.|.
  Rat   427 KMKDSNYVKEFKIPTNITTRTRKTSVTPLRENSLMKL--------------GESALSWESEVFDN 477

  Fly   681 PLVALQHCSIEHERGGKLYVIPGSEDFETYV--------------------NGEL---LKDRRQL 722
            .|..|    .|.|......:: ..|:.|:.:                    |.:|   ||::.:|
  Rat   478 TLEPL----AEAEWSSATALL-SEENLESELTSLNTQYNNLVLDYEQLRRENEDLKLKLKEKNEL 537

  Fly   723 FHGDRLVIGGSHYFRISNPFCSQRGKADHPVDFQLAHQ----EILQKQEQQLRSELEAEKRAALT 783
            ...:               |..||.:.|.  :.||.|:    :.|.|..::...:||.|   ..:
  Rat   538 EEFE---------------FLEQREEKDQ--ELQLMHEVSNLKNLIKHAEEYNQDLENE---LSS 582

  Fly   784 KIE--QERAQHARDFEERLQCLELEQFK--YKCNSEMLETERQAL---------ALAQQQEHTPL 835
            |:|  :|:....::.:..:...:.|..|  ...:||..|..:||:         ||..::|...|
  Rat   583 KVELLKEKEDQIKELQRYIDAQKSETTKTDLSYSSEATEDLKQAMRTLSDLDTVALDAKRESAFL 647

  Fly   836 RHEDAVSTPAQKSTILEDIQRIMLNPSEES---------LHKTQLMVKEATQRCRQLDLPLEFRQ 891
            |.|:           ||..:||  |...:|         :::.||..|:..|...:.:|.|.|::
  Rat   648 RSEN-----------LELKERI--NELSDSCKQMENGIQMYQRQLEAKKQVQADLEKELQLAFQE 699

  Fly   892 ----TQTPDEFGLLRTVIL---ILDKQRGLKAEWPTARLGVWLDLVRDNAEQQEKLNATTIFQSV 949
                :...|..|||..:.|   |.|.|:.|..|            |.:....|::::..:..:|:
  Rat   700 ISKLSALVDGKGLLSNLELEKRITDLQKELNKE------------VEEKETLQKEVHLLSELKSL 752

  Fly   950 EVDWEPLDADLNETLSD---------------THNSSRIALNLSAM---KDVLLNKPLKRLLNAS 996
            ..:.|.|..:|:|...:               .|..|||...|..:   ||.|....|
  Rat   753 PSEVETLRRELHEKSEELCVITTEREKLFSEMAHKDSRIQGLLEEIGNTKDDLAASQL------- 810

  Fly   997 SSKSNTPRQTSTPSPGSQLVHFTKRLLTYDPEEIPESQSSFTTLV-------QQELQIMQRSAQR 1054
            |.:|:.....:..|...:|.|..:.:|. :.|.:.:..|..|..:       |:.|..|:...::
  Rat   811 SQRSSDEECQALKSLHVELKHRQEEVLE-ESERVKQELSQKTQELAQKTAEGQEMLNQMEELREK 874

  Fly  1055 LRRHCEAALLERENHQDNGVLAVSLQEAL 1083
            |.|. :::|...|  ::..:|...||:.|
  Rat   875 LERR-DSSLQSAE--KEKNLLTEKLQQTL 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	147/405 (36%)
		KISc	120..525	CDD:214526	147/404 (36%)
		Kinesin_assoc	524..657	CDD:292801	30/151 (20%)
		FHA	634..740	CDD:238017	21/135 (16%)
Cenpe	XP_038959788.1	KISc_CENP_E	6..329	CDD:276825	146/397 (37%)
		Smc	<334..1057	CDD:224117	133/661 (20%)
		Smc	787..1603	CDD:224117	28/125 (22%)
		Smc	1320..2167	CDD:224117
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000