Protein Alignment neb and Kif14

DIOPT Version :10

• Sequence 1: NP_476817.1
• Gene: neb / 35293
• FlyBaseID: FBgn0004374
• Length: 1121
• Species: Drosophila melanogaster
• Sequence 2: NP_001414162.1
• Gene: Kif14 / 360849
• RGDID: 1310650
• Length: 1672
• Species: Rattus norvegicus
• Alignment Length: 1218
• Identity: 408/1218 - (33%)
• Similarity: 585/1218 - (48%)
• Gaps: 262/1218 - (21%)

  Fly     3 NKSTPVRQRIQQFQTRGVHKSTPASEMRKKVLMTRAEDREHRDRPEQLL----NTAFSG-----S 58
            |....:.:.:..|:.......|||    |.||       |||..|...|    :.|.|.     :
  Rat   293 NNGKDIAKHVSTFRNSSSETQTPA----KCVL-------EHRWAPRHGLPPPKSPALSTLKNRIA 346

  Fly    59 TPQPKPKPTALNACYTPSSLYRNANSTPGRAKTPGTGKSSCSRT-KERDSLMESCLSVSEESNMI 122
            :|:.||:|        .|||.  ||.:...:..|...||:...| .|.|||.      .|.|.:.
  Rat   347 SPRVKPRP--------KSSLL--ANKSSQESTLPPEEKSTVQNTFTEPDSLK------VENSQVT 395

  Fly   123 VAVRVRPLNALECTR--GQVTNVVQVHGNSNELTVQAGSSADASAGVTHFFSYDQVYYSCDPERK 185
            |||||||.:..|.|.  .||     |..|..|:||:......     .:.|.||..::|.|....
  Rat   396 VAVRVRPFSKREKTEKASQV-----VFRNGEEITVEHPDMKQ-----IYSFIYDVAFWSFDECHP 450

  Fly   186 NFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGPPHDEAGII 250
            .:|.|..|:|..|.||:|.||||||.||||||||||||||:|||:             ::|.|||
  Rat   451 GYANQTTVYETLAAPLLDRAFEGYNTCLFAYGQTGSGKSYTMMGL-------------NEEPGII 502

  Fly   251 PRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQQQQRPA 315
            ||||.:||.:| |.|...::...:|:|:||:|||||||||      ...||:       .|::..
  Rat   503 PRFCEDLFAQI-AKKQASEVSYHLEMSFFEVYNEKIHDLL------VCKGEN-------GQRKQP 553

  Fly   316 LKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNIVLNLTDL 380
            |:|||||:.||||..||.:.|.|||.:::||.:||.|||||:|.||||||||||:|.:|:..|..
  Rat   554 LRVREHPVSGPYVEGLSMNVVSSYSDIQSWLELGNKQRATAATGMNDKSSRSHSVFTLVMTQTKT 618

  Fly   381 SSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINKSLLTLGKVIA 445
            ...:|...|.        |.|  |:|:|:|||||||.|.:.|:|||::||||||||||||||||:
  Rat   619 EFVEGEEHDH--------RIT--SRINLIDLAGSERCSTAHSSGERLKEGVSINKSLLTLGKVIS 673

  Fly   446 ALADSRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASIHADETLATLR 510
            ||::.    |||      ...|:|||||.|||||:|:|||||||.|:||||||:.:.:|||:|||
  Rat   674 ALSEQ----ANG------KRVFIPYRESTLTWLLKESLGGNSKTAMIATISPAASNIEETLSTLR 728

  Fly   511 YACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSLRNEYERQRRLSGNSNNPVPRKIIIETSVD 575
            ||.:||.|||..||||..:.|:||:|:||:::||:.:.          :|.|..|.:.    .:.
  Rat   729 YATQARLIVNVAKVNEDMNAKLIRELKAEIEKLKAAQK----------SSRNIDPERY----RLC 779

  Fly   576 ETEVEALRQQLAERERELSRAQKSWMEKLKEAEDQRKSELRVLKRRGLALELTAEQKQACLVNLT 640
            ..|:.:||.:|.::||:::..|:.|.||.::||.::..|.:.|::.|:..::  :.....||||.
  Rat   780 RQEISSLRMKLHQQERDMAEIQRVWKEKFEQAEKRKLQETKELQKAGVTFQM--DNHLPNLVNLN 842

  Fly   641 ADPILSGTLFYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVALQHCSIEHERGGKLYVIPGSE 705
            .||.||..|.|::.:|:..:|:     .:.:|..||.|.|.|:|..||:| ...||.:.::|..|
  Rat   843 EDPQLSEMLLYMVKEGITTVGK-----HTPNSSHDIQLSGVLIADDHCTI-RSYGGTVSIVPAGE 901

  Fly   706 DFETYVNGELLKDRRQLFHGDRLVIGGSHYFRISNPFCSQRGK--------ADHPVDFQLAHQEI 762
             .:|||||..:.:...|.||||:|:||.||||.::|...|:||        ::.|.||:.|..|:
  Rat   902 -AKTYVNGMHISEPTVLHHGDRVVLGGDHYFRFNHPVEVQKGKKTSRNNLTSEGPKDFEFAKNEL 965

  Fly   763 LQKQEQQLRSE----------------------------------------LEAE-----KRAAL 782
            |..|..:|.:|                                        ||||     :|..|
  Rat   966 LAAQRSRLEAEIKDAQLKAKEEMMQGIQIAKEMAQQELSSQRAAYENKIRALEAELREESQRKRL 1030

  Fly   783 TKIEQERAQH-ARDFEERLQCLELEQFKYKCNSEMLETERQALALAQQQEHTPLRHE---DAVST 843
            .:|..::|.| ..:.|:..|.||.|.:..|...||     :.||..|..|...:||.   :|:..
  Rat  1031 EEINNQKASHKIEELEKAKQHLEQEVYVNKRRLEM-----ETLATKQALEDHRIRHARILEALER 1090

  Fly   844 PAQKSTILEDIQRIMLN-----------PSEESLHKTQLMVKEATQRCRQLDLPLEFRQTQTPDE 897
            ..||  |.|::|.:..|           |:..|: |...|::||.....:......|.:....|:
  Rat  1091 EKQK--IAEEVQILQENRGNRNKTFTIQPNWSSM-KLSTMIQEANAISDKFKKHYVFGRHDASDK 1152

  Fly   898 FGLLRTVILILDKQRGLKAEWPTARLGVWLDLVRDNAEQQEKLNATTIFQSVEVDWEPLDADLNE 962
             |.....:.:.:.|.|:...|...:....|..::|..|.........:|...|.:|||   |:..
  Rat  1153 -GRSDPSVRVRNLQLGISTFWNLEKFESKLAAMKDLYESNSGTRGEDVFCDPEDEWEP---DITS 1213

  Fly   963 T----LSDTHNSS-----RIALNLSAMKDV-------------LLNKPLKRLLNASSS------- 998
            |    ||...:.|     |::   ..:.|:             |:.||.....|:|.|
  Rat  1214 TPVSSLSRRRSRSLMKNRRVS---GCLHDIHPIQSMHPSHTSGLMEKPSTIYSNSSESFLPGICK 1275

  Fly   999 -----------KSNTPRQTSTPSPGSQLVHFTKRLLTYD---PEEIPESQSS-FTTLVQQELQIM 1048
                       :|....:|...|..:.|:.....::...   .|:..|||.: |:....|.|.|.
  Rat  1276 ELIGSSIDFLGQSFDEEKTIADSLINNLLKLYNGVIAISKAHEEQDEESQDNVFSDRAAQALTIQ 1340

  Fly  1049 QRSAQR----LRRH-------CE-AALLERENHQD----NGVLAVSLQ 1080
            ...|..    |.:|       |. :|.||.|..||    .|.|.:.||
  Rat  1341 VACAFEQLVVLFKHWLDDFPPCSGSARLEEELRQDIKKLGGYLQLFLQ 1388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	201/407 (49%)
		SMC_N	514..>615	CDD:481474	32/100 (32%)
		FHA_KIF14	627..741	CDD:438759	43/113 (38%)
Kif14	NP_001414162.1	None