Protein Alignment neb and Klp31E

DIOPT Version :10

• Sequence 1: NP_476817.1
• Gene: neb / 35293
• FlyBaseID: FBgn0004374
• Length: 1121
• Species: Drosophila melanogaster
• Sequence 2: NP_609398.2
• Gene: Klp31E / 34422
• FlyBaseID: FBgn0032243
• Length: 1048
• Species: Drosophila melanogaster
• Alignment Length: 1128
• Identity: 263/1128 - (23%)
• Similarity: 431/1128 - (38%)
• Gaps: 337/1128 - (29%)

  Fly   114 SVSEESNMIVAVRVRPLNALE-------CTRGQVTNVVQVHGNSNELTVQAGSSADASAGVTHFF 171
            |::::|::.||||:||.|:.|       ||                 ||..| ......|....|
  Fly     7 SINKDSSVRVAVRIRPQNSRELIDMCRICT-----------------TVTLG-EPQIFLGSDKAF 53

  Fly   172 SYDQVY----YSCDPERKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSM-MGI- 230
            ::|.|:    ..||           ::......|:|:...||||.:.|||||||||:|:| .|.
  Fly    54 TFDYVFDTNSNQCD-----------IYSDCVEKLVDSTLHGYNATVLAYGQTGSGKTYTMGTGFD 107

  Fly   231 ---EALDDAALDGGPPHDEAGIIPRFCHELFRRIEAVKSQQ---------QLQVEVEVSYFEIYN 283
               |:.|...|         |||||....:|..||.::...         ..|..:.|.|.|:||
  Fly   108 HESESSDSVQL---------GIIPRAVRHIFSGIEQLEGSSTSEHPAAGGSPQFSLAVQYIELYN 163

  Fly   284 EKIHDLLSVQHAAAATGESTPIQQQQQQQRPALKVRE-------------HPIFGPYVVDLSAHS 335
            |.|.|||.            |..:...     .|:.|             .||:.|
  Fly   164 EDIFDLLD------------PFNKNSN-----FKIHEDASGQITISGASIKPIYQP--------- 202

  Fly   336 VDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNIVLNLTDLSSDDGLSSDTDSSTASSLRQ 400
               :.||: :|..|...|.||||.|||:|||||::|.|.:....|.:......|.|..|.:
  Fly   203 ---HDALK-YLQQGALARTTASTKMNDQSSRSHALFTIFVRRQRLLTPSDNVPDNDLETLT---- 259

  Fly   401 TRRSKISLVDLAGSERISVSGSNGERIREGVSINKSLLTLGKVIAALAD-SRKAIANGPLGSGTP 464
               ||...||||||||:..:.:.|||.|||:|||..||.||..|:||.| |::|:
  Fly   260 ---SKFHFVDLAGSERLKRTQATGERAREGISINCGLLALGNCISALGDKSKRAL---------- 311

  Fly   465 STFVPYRESVLTWLLRENLGGNSKTVMLATISPASIHADETLATLRYACKARSIVNRVKVNESPH 529
              .||||:|.||.||:::|||||:|:|:|.:||:.....|||.||:||.:||:|.|:||:|:...
  Fly   312 --HVPYRDSKLTRLLQDSLGGNSQTLMIACVSPSDRDFMETLNTLKYANRARNIKNKVKINQDQS 374

  Fly   530 DKIIRDLRAEVDRLKSLRNEYERQRRLSGNSNNPVPRKIIIETSVDETEVEALRQQLAERER--- 591
            .:.|..||.|:..|:....||::.:.:.....|........|..:..:|::.|:|:|...:.
  Fly   375 SRTISQLRREIAALQLELLEYKQGKLIVDCEGNTTISDTFNENKLLLSEIKRLQQRLKSLQSTIA 439

  Fly   592 --------------------------ELSRAQKSWM-------EKLKEAEDQRKSELRVLKRRGL 623
                                      |:::....:|       .||.|:|:.||.         :
  Fly   440 TLTQRNADLKTNLDLNKWTSDDNSDVEIAKVVGQYMLEIEELQTKLIESEEHRKQ---------M 495

  Fly   624 ALELTAEQKQACLVNLTADPILSGTLFYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVALQHC 688
            .::.|...:       .|.|:....:.....:.|.|             :.::::...|..:|:.
  Fly   496 EIKATTSPR-------NAKPVYDSDIITKAKKDLER-------------ERELLMSRSLPGIQNQ 540

  Fly   689 SIEHERGGKLYVIPGSEDFETYVNGELLKDRRQLFHGDRLVIGGSHYFRISNPFCSQRGKADHPV 753
            ::..|.     ....|.|.|.   .|::||...:                           |:.:
  Fly   541 NVSSEE-----TEVASSDSEA---EEVVKDLEAI---------------------------DNDI 570

  Fly   754 DFQ---LAHQEILQKQEQQLRSELEAEKRAALTKIEQERAQHARD-------------FEERLQC 802
            :.:   :...|:...:.:|:|:..|.:......||  |..|..||             .::.|:.
  Fly   571 EMRTKLIEQLELTNSRYEQMRTHYEEKLSVLYCKI--ENTQKERDDVLANMTTSVSTPSKDSLKK 633

  Fly   803 LELEQFKYKCNSEMLETERQALALAQQQEHTPLR-----HEDAVSTPAQKSTILEDIQ-RIMLNP 861
            ::.:   |:.....::||.:.|..| |:||...:     ||..:.|...:...|:..: ::|...
  Fly   634 VKTD---YESKISHMQTEIRKLQNA-QREHIRSKQQLKSHEVRIGTLRNELNELKFAKVKLMKKM 694

  Fly   862 SEES-LHK----------TQLMVKEATQRCRQLDLPLEF--------RQTQTPDEFGLLRTVILI 907
            |::| .||          .||:.::..|:...|.|..:.        |:|:         .||.:
  Fly   695 SQQSNRHKQEESRKSKEIAQLLKEQRRQKNAVLTLEAKVSAKEQILKRKTE---------EVIAL 750

  Fly   908 LDKQRGLKAEWPTARLGVWLDLVRDNAEQQEKLNATTIF--QSVEVDWEPLDADLNETLSDTHNS 970
            ...|||...:             |..|....|:.....|  :|....||.|..::.....:....
  Fly   751 RKSQRGKSGQ-------------RAPAHLTSKIATLDGFSTRSARHRWENLYRNILHAARNRQLI 802

  Fly   971 SRIALNLSAMKDVLLNKPLKRLLNASSSKSNTPRQTSTPSPGSQLVHFTKRLLTYDPEEIPESQS 1035
            :::...|..:  :|..:.|.|.||...:.....|||...:....|    |..::|..|.|...|.
  Fly   803 TQLEKELERL--ILEREDLSRELNIMENGQTADRQTDEFNEVDNL----KTNISYIQENIEHVQQ 861

  Fly  1036 SF------------------------TTLVQQELQIMQRSAQRLRRHCEAALLE----------R 1066
            :.                        :|:.:.:..:.:.|...:...|..|:.|          :
  Fly   862 AIMEFEDTKDTVQSHVNKIQSLLDEVSTVAEAKFILQKFSDTAIVMSCNLAIAESHLQEKESLLK 926

  Fly  1067 ENHQDNGVLAVSLQEALARMDTV 1089
            |..|::|:....||..|::...|
  Fly   927 EVKQESGIQQQILQHFLSQNSNV 949

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	150/444 (34%)
		SMC_N	514..>615	CDD:481474	28/136 (21%)
		FHA_KIF14	627..741	CDD:438759	14/113 (12%)
Klp31E	NP_609398.2	KISc_KIF4	12..364	CDD:276823	146/438 (33%)
		Mplasa_alph_rch	<372..>748	CDD:275316	71/454 (16%)
		SMC_prok_B	622..>899	CDD:274008	54/308 (18%)
		Rcc_KIF21	798..870	CDD:410202	15/77 (19%)