DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment neb and nod

DIOPT Version :9

Sequence 1:	NP_476817.1	Gene:	neb / 35293	FlyBaseID:	FBgn0004374	Length:	1121	Species:	Drosophila melanogaster
Sequence 2:	NP_001285129.1	Gene:	nod / 32107	FlyBaseID:	FBgn0002948	Length:	666	Species:	Drosophila melanogaster

Alignment Length:	578	Identity:	140/578 - (24%)
Similarity:	220/578 - (38%)	Gaps:	151/578 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 VAVRVRPLNALECTRGQVTNVVQVHGNSNELTVQAGSSADASAGVTHFFSYDQVYYSCDPERKNF 187
            :|||..|..             |..|......||....:|..:.:.     ||..:..|......
  Fly    11 IAVREAPYR-------------QFLGRREPSVVQFPPWSDGKSLIV-----DQNEFHFDHAFPAT 57

  Fly   188 ACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGPP----HDEAG 248
            ..|.::::....||:|...||:.....||||||:||||| ||:.          ||    .:..|
  Fly    58 ISQDEMYQALILPLVDKLLEGFQCTALAYGQTGTGKSYS-MGMT----------PPGEILPEHLG 111

  Fly   249 IIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQQQQR 313
            |:||...::|.|:.|.:...:..::|..|:.||||||..|||.          |||
  Fly   112 ILPRALGDIFERVTARQENNKDAIQVYASFIEIYNEKPFDLLG----------STP--------- 157

  Fly   314 PALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNIVLNLT 378
                  ..|:........:...:.|.:.|.:.|.:|...|....|.||..|||||:|..|.:.
  Fly   158 ------HMPMVAARCQRCTCLPLHSQADLHHILELGTRNRRVRPTNMNSNSSRSHAIVTIHVK-- 214

  Fly   379 DLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINKSLLTLGKV 443
                                .:|..|::::|||||||.:..:|..|...:|||:||..||::.||
  Fly   215 --------------------SKTHHSRMNIVDLAGSEGVRRTGHEGVARQEGVNINLGLLSINKV 259

  Fly   444 IAALADSRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASIHADETLAT 508
            :.::|...              |.:|||:||||.:|:.:|...|....||.|||......|||:|
  Fly   260 VMSMAAGH--------------TVIPYRDSVLTTVLQASLTAQSYLTFLACISPHQCDLSETLST 310

  Fly   509 LRYACKAR--------------SIVNR--------------VKVNESPHDKIIRDLRAEVDRLKS 545
            ||:...|:              |:..|              :|.|.:.|:.|:.. :::....|.
  Fly   311 LRFGTSAKKLRLNPMQVARQKQSLAARTTHVFRQALCTSTAIKSNAANHNSIVVP-KSKYSTTKP 374

  Fly   546 LRNEYERQRRLSGNSNNPVPR-KIIIETSVDETEVEALRQQ-----------------------L 586
            |.....|.|...|.:.....| :.::|......|:.::..|                       .
  Fly   375 LSAVLHRTRSELGMTPKAKKRARELLELEETTLELSSIHIQDSSLSLLGFHSDSDKDRHLMPPPT 439

  Fly   587 AERERELSRAQKSWMEKLKEAEDQRKSELRVLKRRGLALELTAEQKQACLVNLTADPI 644
            .:..|:.|....:.|..::|.|.:..|::    ::.:.........:..|.|.|..||
  Fly   440 GQEPRQASSQNSTLMGIVEETEPKESSKV----QQSMVAPTVPTTVRCQLFNTTISPI 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	117/433 (27%)
		KISc	120..525	CDD:214526	117/433 (27%)
		Kinesin_assoc	524..657	CDD:292801	23/145 (16%)
		FHA	634..740	CDD:238017	5/11 (45%)
nod	NP_001285129.1	KISc	8..325	CDD:214526	114/403 (28%)
		KISc	8..318	CDD:276812	113/396 (29%)
		ComEA	540..648	CDD:224472
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437916
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030