DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment neb and Klp10A

DIOPT Version :9

Sequence 1:	NP_476817.1	Gene:	neb / 35293	FlyBaseID:	FBgn0004374	Length:	1121	Species:	Drosophila melanogaster
Sequence 2:	NP_001285109.1	Gene:	Klp10A / 32049	FlyBaseID:	FBgn0030268	Length:	805	Species:	Drosophila melanogaster

Alignment Length:	566	Identity:	157/566 - (27%)
Similarity:	234/566 - (41%)	Gaps:	142/566 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 STPASEMRKKVLMTRAEDREHRDRPEQLLNTAFSGSTPQPKPKPTALNACYTPSSLYRNANSTPG 87
            ||..|...|:|...: |:||.| |..|          .:.|.:..||            .|..||
  Fly   206 STRRSHALKEVERLK-ENREKR-RARQ----------AEMKEEKVAL------------MNQDPG 246

  Fly    88 RAKTPGTGKSSCSRTKERDSLMESCLSVS----EESNMIVAVRVRPLNALECTRGQVTNVVQVHG 148
            ....     .:....:|..|.:|....:.    ::..:.|.||.||::..|..|.:: :|:.|..
  Fly   247 NPNW-----ETAQMIREYQSTLEFVPLLDGQAVDDHQITVCVRKRPISRKEVNRKEI-DVISVPR 305

  Fly   149 NSNELTVQAGSSADASAGV-THFFSYDQVYY-SCDPERKNFACQAKVFEGTARPLIDTAFEGYNA 211
            ....:..:..|..|.:..: .|.|.:|..:. :||        .|.|::.||:||:.|.|||..|
  Fly   306 KDMLIVHEPRSKVDLTKFLENHKFRFDYAFNDTCD--------NAMVYKYTAKPLVKTIFEGGMA 362

  Fly   212 CLFAYGQTGSGKSYSMMGIEALDDAALDGGPPHDEAGIIPRFCHELFRRIEAVKSQQQLQVEVEV 276
            ..||||||||||:::|.|       ..:|.....:.||......::|..:. :...:.:.:.|..
  Fly   363 TCFAYGQTGSGKTHTMGG-------EFNGKVQDCKNGIYAMAAKDVFVTLN-MPRYRAMNLVVSA 419

  Fly   277 SYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQQQQRPALKVREHPIFGPYVVDLSAHSVDSYSA 341
            |:||||:.|:.||||                    .:..|:|.|.......||.|:...||....
  Fly   420 SFFEIYSGKVFDLLS--------------------DKQKLRVLEDGKQQVQVVGLTEKVVDGVEE 464

  Fly   342 LRNWLAVGNSQRATASTAMNDKSSRSHSIFNIVLNLTDLSSDDGLSSDTDSSTASSLRQTRRSKI 406
            :...:..||:.|.:..|:.|..|||||::|.|||.....:...|                   |.
  Fly   465 VLKLIQHGNAARTSGQTSANSNSSRSHAVFQIVLRPQGSTKIHG-------------------KF 510

  Fly   407 SLVDLAGSER-ISVSGSNGERIREGVSINKSLLTLGKVIAALADSRKAIANGPLGSGTPSTFVPY 470
            |.:||||:|| :..|.::.:...||..||||||.|.:.|.||              |..|..:|:
  Fly   511 SFIDLAGNERGVDTSSADRQTRMEGAEINKSLLALKECIRAL--------------GKQSAHLPF 561

  Fly   471 RESVLTWLLREN-LGGNSKTVMLATISPASIHADETLATLRYACKARSIVNRVKVNESPHDKIIR 534
            |.|.||.:||:: :|..|||.|:|.|||.....:.||.|||||       :|||      :.:::
  Fly   562 RVSKLTQVLRDSFIGEKSKTCMIAMISPGLSSCEHTLNTLRYA-------DRVK------ELVVK 613

  Fly   535 DLRAEVDRLKSLRNEYERQRRLSGNSNNPVPRKIIIETSVDETEVE 580
            |: .||               ..|....|      ||.:.||.|.|
  Fly   614 DI-VEV---------------CPGGDTEP------IEITDDEEEEE 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	126/409 (31%)
		KISc	120..525	CDD:214526	126/408 (31%)
		Kinesin_assoc	524..657	CDD:292801	11/57 (19%)
		FHA	634..740	CDD:238017
Klp10A	NP_001285109.1	KISc_KIF2_like	278..608	CDD:276818	124/406 (31%)
Klp10A	NP_001285109.1	Kinesin	284..609	CDD:278646	124/407 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437826
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030