Protein Alignment neb and Kif16b

DIOPT Version :10

• Sequence 1: NP_476817.1
• Gene: neb / 35293
• FlyBaseID: FBgn0004374
• Length: 1121
• Species: Drosophila melanogaster
• Sequence 2: XP_038960967.1
• Gene: Kif16b / 311478
• RGDID: 1310146
• Length: 1876
• Species: Rattus norvegicus
• Alignment Length: 1103
• Identity: 319/1103 - (28%)
• Similarity: 509/1103 - (46%)
• Gaps: 237/1103 - (21%)

  Fly   133 LECTRGQVTNVVQVHGNSNELTVQAGSSADASAGVTHFFSYDQVYYSCDPERKNFACQAKVFEGT 197
            :|.::..:||          |.:..|.:.|:....|..|:||..:||.|.:..::..|..||:..
  Rat    31 MEKSKTTITN----------LKIPEGGTGDSGRERTKTFTYDFSFYSADTKSPDYVSQETVFKTL 85

  Fly   198 ARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGPPHDEAGIIPRFCHELFRRIE 262
            ...::.:||||||||:||||||||||||:|||         :.|    ::|:|||.|..||.||.
  Rat    86 GTDVVKSAFEGYNACVFAYGQTGSGKSYTMMG---------NSG----DSGLIPRICEALFSRIN 137

  Fly   263 AVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQQQQRPALKVREHPIFGPY 327
            ......:.....||||.|||||::.|||                :::..:...|:|||||..|||
  Rat   138 ETTRWDEASFRTEVSYLEIYNERVRDLL----------------RRKSSKTFNLRVREHPKEGPY 186

  Fly   328 VVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNIVLNLTDLSSDDGLSSDTDS 392
            |.|||.|.|.:||.:...:..||..|.||:|.|||.|||||:||.|  ..|....|..:..:|
  Rat   187 VEDLSKHLVQNYSDVEELMDAGNINRTTAATGMNDVSSRSHAIFTI--KFTQAKFDAEMPCET-- 247

  Fly   393 STASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINKSLLTLGKVIAALADSRKAIANG 457
                      .|||.|||||||||...:|:.|.|::||.:|||||:|||.||:||||..:..||
  Rat   248 ----------VSKIHLVDLAGSERADATGATGVRLKEGGNINKSLVTLGNVISALADLSQDAAN- 301

  Fly   458 PLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASIHADETLATLRYACKARSIVNRV 522
            ||.. ....|||||:|||||||:::|||||||:|:||||||.::..|||:|||||.:|::|:|:.
  Rat   302 PLVK-KKQVFVPYRDSVLTWLLKDSLGGNSKTIMIATISPADVNYGETLSTLRYANRAKNIINKP 365

  Fly   523 KVNESPHDKIIRDLRAEVDRLKSLRNEYERQRRLSGNSNNPVPRKIIIETSVDETEVEALRQQLA 587
            .:||..:.|:||:||||:.|||:|..:        ||       :|.:   :|.....::.::|.
  Rat   366 TINEDANVKLIRELRAEIARLKTLLAQ--------GN-------QIAL---LDSPTALSMEEKLH 412

  Fly   588 ERERELSRAQKSWMEKLKEAEDQRKSELRVLKRRGLALELTAEQKQACLVNLTADPILSGTLFYL 652
            :.|..:....|.|..|..|.::..|.:...|::.|:.:.|.:|...  |:.:..|.:.:|.:.|.
  Rat   413 QNEARVQELTKEWTNKWNETQNILKEQTLALRKEGIGVVLDSELPH--LIGIDDDLLSTGIILYH 475

  Fly   653 LPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVALQHCSIEHERGGKLYVIP--GSEDFETYVNGEL 715
            |.:|...:||     ..:|::.||||.|..:..:||..|: .||.:.:||  ||   :..|||..
  Rat   476 LKEGQTYVGR-----EDASTEQDIVLHGLDLESEHCVFEN-AGGTVTLIPLSGS---QCSVNGVQ 531

  Fly   716 LKDRRQLFHGDRLVIGGSHYFRISNP----FCSQRGKADHPVDFQLAHQEILQKQEQQ------- 769
            :.|..||..|..:::|.::.||.::|    ...::.|:.....|.|:..::.:..|..
  Rat   532 IVDATQLNQGAVILLGRTNMFRFNHPKEAAKLREKRKSGLLSSFSLSMTDLSKSCENLSAVMLYN 596

  Fly   770 -----------LRSELEAEKRAALTKIEQERAQHARDFEERLQC--LELEQFKYKCNSEMLETE- 820
                       ||.|.|.::|..|.|:|.:| :...:.||:.:.  .|||:.:.:..:...|||
  Rat   597 PGLFPMKGPICLRLEFERQQREELEKLESKR-KLIEEMEEKQKSDKAELERMQQEVETRRKETEI 660

  Fly   821 -----------------------RQALALAQQQEHTPLRHEDAVSTPAQKS-----TILEDIQRI 857
                                   :..||..::.|...||.:..:....::.     .|.|:::|:
  Rat   661 VQRQIRKQEESLKRRSFHIENKLKDLLAEKERFEEERLREQQGLEQQKRQEEDSFFRIREELRRL 725

  Fly   858 M-LNPSEES-----------LH--------KTQL-------MVKEATQRCRQLDLPLEFRQTQTP 895
            . ||..|::           ||        |.||       ..||...|...|:..|..||...|
  Rat   726 QELNSHEQAEKGQPLQDLDWLHREQDAQSAKLQLEKRRLEEQEKEQVLRVAHLEEQLRKRQDTAP 790

  Fly   896 --------------DEFGLLRTVIL---------------ILDKQRGLKAEWPTARLGVWLDLVR 931
                          .|...:|..:|               .|::.:....|:...:|.....|.:
  Rat   791 LLCPGEAQQAQEERRELEGIRGALLQAKEIRAGGDHTFRGELERAQQYFLEFKRRQLVKLATLEK 855

  Fly   932 DNAEQQEKLNATTIFQSVEVDWEPLDADLNETLSDTHN----------------SSRIALNLSAM 980
            |..:|:::|:.....:...::....:|....:|..|.|                .||:......:
  Rat   856 DLVQQKDRLSKEVQEEKEALEHVKCEAGEEPSLLATDNCNILCGPQDLDKIKTAESRLQSKEHQL 920

  Fly   981 KDVLLNKPLKRLLNASSSKSNTPRQTSTPSPG----SQLVHFTKRLLTYDPEEIPESQSSFTTLV 1041
            :|:|.|. |..||....      |.......|    ..:::..::.:....|:|.:.|::.:.|.
  Rat   921 QDLLQNH-LPALLEEKQ------RVLEILDCGVLGLDNILYHVEKEMEEKEEQITQYQANASQLQ 978

  Fly  1042 QQELQI-----MQRSAQRLRRHCEAALLERENHQDNGVLAVSLQEALARMDTVLNGMHTSLAR 1099
            |.:..:     :.|..:::||. |..:||.:..|..    .:|::|:|:::.    .|::|.|
  Rat   979 QLQATVQFTANVARQEEKVRRK-EKEILESQEKQQR----EALEQAVAKLEQ----RHSALKR 1032

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	170/391 (43%)
		SMC_N	514..>615	CDD:481474	27/100 (27%)
		FHA_KIF14	627..741	CDD:438759	35/115 (30%)
Kif16b	XP_038960967.1	KISc_KIF1A_KIF1B	15..368	CDD:276816	170/391 (43%)
		Kinesin_assoc	367..479	CDD:465047	33/131 (25%)
		FHA	449..565	CDD:469597	36/126 (29%)
		Smc	<609..>1087	CDD:440809	82/441 (19%)