DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment neb and Kif13a

DIOPT Version :9

Sequence 1:	NP_476817.1	Gene:	neb / 35293	FlyBaseID:	FBgn0004374	Length:	1121	Species:	Drosophila melanogaster
Sequence 2:	NP_001100932.1	Gene:	Kif13a / 308173	RGDID:	1307825	Length:	1689	Species:	Rattus norvegicus

Alignment Length:	1018	Identity:	305/1018 - (29%)
Similarity:	470/1018 - (46%)	Gaps:	226/1018 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 FACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGPPH-DEAGII 250
            :|.|..||:.....:::.||:|||||:|||||||||||:||||              | ::.|:|
  Rat     9 YAGQEVVFKCLGEGILEKAFQGYNACIFAYGQTGSGKSFSMMG--------------HAEQLGLI 59

  Fly   251 PRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQQQQRPA 315
            ||.|..||:||...:::.| ..:|||||.||||||:.|||                 ..:..|.:
  Rat    60 PRLCCALFQRISLEQNESQ-TFKVEVSYMEIYNEKVRDLL-----------------DPKGSRQS 106

  Fly   316 LKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNIVLNLTDL 380
            ||||||.:.||||..||..:|.|:..:.:.::.||..|..|:|.||::|||||::|||::..|..
  Rat   107 LKVREHKVLGPYVDGLSQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLY 171

  Fly   381 SSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINKSLLTLGKVIA 445
            ....|.|.:            :.||:||||||||||:|.:|:.|||::||.:|||||.|||.||:
  Rat   172 DLQSGNSGE------------KVSKVSLVDLAGSERVSKTGAAGERLKEGSNINKSLTTLGLVIS 224

  Fly   446 ALADSRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASIHADETLATLR 510
            :|||.       ..|.| .:.|||||:|||||||::||||||:|.|:||||||:.:.:|||:|||
  Rat   225 SLADQ-------AAGKG-KNKFVPYRDSVLTWLLKDNLGGNSQTSMIATISPAADNYEETLSTLR 281

  Fly   511 YACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSLRNEYERQRRLSGNSNNPVPRKIIIETSVD 575
            ||.:|:.|||...|||.|:.|:||:||.||::|:...::.|..:
  Rat   282 YADRAKRIVNHAVVNEDPNAKVIRELREEVEKLREQLSQAEAMK--------------------- 325

  Fly   576 ETEVEALRQQLAERERELSRAQKSWMEKLKEAEDQRKSELRVLKRRGLALE---LTAEQKQACLV 637
               ...|:::|.|.|:.:.....:|.|||::.|:..:...|.|:..|::||   :.....:..||
  Rat   326 ---APELKEKLEESEKLIKELTVTWEEKLRKTEEIAQERQRQLESMGISLETSGIKVGDDKCYLV 387

  Fly   638 NLTADPILSGTLFYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVALQHCSIEHERGGKLYVIP 702
            ||.|||.|:..|.|.| :...|:       |:.:|| ||.|.|..:..:||.|:....|.:.:.|
  Rat   388 NLNADPALNELLVYYL-KDHTRV-------GADTSQ-DIQLFGIGIQPEHCEIDIATDGDITLTP 443

  Fly   703 GSEDFETYVNGELLKDRRQLFHGDRLVIGGSHYFRISNP----------FCSQRGKADHPVD--- 754
             .|:..:.|||.|:....||:||||::.|.:|:|||:.|          |..:....:|.:|
  Rat   444 -KENARSCVNGTLVCSVTQLWHGDRILWGNNHFFRINLPKRKRRDWLKDFEKETSATEHDLDAAS 507

  Fly   755 ---------FQLAHQEILQKQ----------EQQLRSELEAEKRAALTKIEQERAQHARDFEERL 800
                     ::.|..|::.|.          .|.|..:...|||.||   |::|..:.|:.|:..
  Rat   508 EASSEPDYNYEFAQMEVIMKTLNSNDPVQNVVQVLEKQYLEEKRTAL---EEQRLMYERELEQLR 569

  Fly   801 QCLELEQFKYKCNSEMLETERQALALAQQQEHTPLRHEDAVSTPAQKSTILEDIQRIMLNPSEES 865
            |.|..|:......|:.|....|.   |||:          |:..|::.   :::.|..|....|.
  Rat   570 QQLSPERQPPSSASDRLAYSSQT---AQQK----------VTQWAEER---DELFRQSLAKLREQ 618

  Fly   866 LHKTQLMVKEATQRCRQLDLPLEFRQT-QTPDEFGLLRTVILILDKQRGLKAEWPTARLGVWLDL 929
            |.|...:|:||.....::....:::.| |.|       ...|..:::||.              :
  Rat   619 LVKANTLVREANFLAEEMGKLTDYQVTLQIP-------AANLSANRKRGA--------------I 662

  Fly   930 VRDNAEQQEKLNATTIFQSVE------VDWEPLDADLNETL-----------------SDTHNSS 971
            |.:.|.|..:...:|...::|      :|...|..:..|.:                 .:.||..
  Rat   663 VSEPAIQARRKGKSTQVWTIEKLENKLIDMRDLYQEWKENVPKAKRLCGKRGDPFYEAQENHNLI 727

  Fly   972 RIALNLSAMKDVLLNKPLKRLLNASSSKSNTPRQTSTPSPGSQLVHFTKRLLTYDPEEIPESQSS 1036
            .:|           |..|:.|......:...|..:.......:|.....|:....||.:.|..||
  Rat   728 GVA-----------NVFLECLFCDVKLQYAVPIISQQGEVAGRLHVEVMRVTGTVPERVSEDDSS 781

  Fly  1037 FTTLVQQELQIMQRSAQRLRR----HCEAALLERENHQDNGVLAVSLQEALARMDTVLNGMHTSL 1097
            ..:.....|:::..|.:.:.|    .|...:.|...      |.:||...:....|..:...:::
  Rat   782 ENSSESGSLEVVDSSGEVIHRVKKLTCRVIIKEATG------LPISLSNFVFCQYTFWDQYESTV 840

  Fly  1098 ARAEATACVTSP-------------------TKTQKAVRFLID 1121
            |.......|.||                   |.|::.:.|:.|
  Rat   841 AAPVVDPDVPSPQSKDAQYTVTFSHCKDYVVTVTEEFLEFISD 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	156/338 (46%)
		KISc	120..525	CDD:214526	156/338 (46%)
		Kinesin_assoc	524..657	CDD:292801	38/135 (28%)
		FHA	634..740	CDD:238017	40/105 (38%)
Kif13a	NP_001100932.1	Motor_domain	3..296	CDD:277568	156/338 (46%)
		KISc	9..296	CDD:214526	156/338 (46%)
		Kinesin_assoc	293..405	CDD:292801	38/136 (28%)
		FHA	383..480	CDD:238017	40/106 (38%)
		KIF1B	685..729	CDD:289208	5/43 (12%)
		DUF3694	<1148..1207	CDD:289256
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920