DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment neb and Kif13b

DIOPT Version :9

Sequence 1:	NP_476817.1	Gene:	neb / 35293	FlyBaseID:	FBgn0004374	Length:	1121	Species:	Drosophila melanogaster
Sequence 2:	NP_998791.1	Gene:	Kif13b / 305967	RGDID:	1303307	Length:	1767	Species:	Rattus norvegicus

Alignment Length:	917	Identity:	296/917 - (32%)
Similarity:	448/917 - (48%)	Gaps:	218/917 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 ESNMIVAVRVRPLNALE------CTRGQVTNVVQVHGNSNELT-VQAGSSADASAGVTHFFSYDQ 175
            :|.:.|||||||:|..|      |       ||.|..|...|. :....|...:.|....|:||.
  Rat     3 DSKVKVAVRVRPMNRREIDLHTKC-------VVDVEANKVILNPINTNLSKGDARGQPKIFAYDH 60

  Fly   176 VYYSCDPE-RKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALD 239
            .::|.|.. |:.:|.|..||:.....::..||:|||||:||||||||||||:|||..
  Rat    61 CFWSMDESVREKYAGQDDVFKCLGENILQNAFDGYNACIFAYGQTGSGKSYTMMGTA-------- 117

  Fly   240 GGPPHDEAGIIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTP 304
                 |:.|:|||.|..||.|.:..::::| ..:|||||.||||||:.|||
  Rat   118 -----DQPGLIPRLCSGLFERTQKEENEEQ-SFKVEVSYMEIYNEKVRDLL-------------- 162

  Fly   305 IQQQQQQQRPALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHS 369
               ..:..|..||||||.:.||||..||..:|.||..:.:.::.||..|..|:|.||::|||||:
  Rat   163 ---DPKGSRQTLKVREHSVLGPYVDGLSKLAVTSYKDIESLMSEGNKSRTVAATNMNEESSRSHA 224

  Fly   370 IFNIVLNLTDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSIN 434
            :|.|.|..|......|.|.:            :..|:||||||||||.:.:|:.|:|::||.:||
  Rat   225 VFKITLTHTLYDVKSGTSGE------------KVGKLSLVDLAGSERATKTGAAGDRLKEGSNIN 277

  Fly   435 KSLLTLGKVIAALADSRKAIANGPLGSG-TPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPA 498
            |||.|||.||:||||.         |:| ..:.|||||:|||||||:::|||||||.|:||:|||
  Rat   278 KSLTTLGLVISALADQ---------GAGKNKNKFVPYRDSVLTWLLKDSLGGNSKTAMVATVSPA 333

  Fly   499 SIHADETLATLRYACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSLRNEYERQRRLSGNSNNP 563
            :.:.||||:|||||.:|:.|:|...|||.|:.:||||||.||::|:....:.|..:       :|
  Rat   334 ADNYDETLSTLRYADRAKHIINHAVVNEDPNARIIRDLREEVEKLREQLTKAEAMK-------SP 391

  Fly   564 VPRKIIIETSVDETEVEALRQQLAERERELSRAQKSWMEKLKEAEDQRKSELRVLKRRGLALE-- 626
                             .|:.:|.|.|:.:.....:|.|||::.|:..:...:.|:..|::|:
  Rat   392 -----------------ELKDRLEESEKLIQEMTVTWEEKLRKTEEIAQERQKQLESLGISLQTS 439

  Fly   627 -LTAEQKQACLVNLTADPILSGTL-FYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVALQHCS 689
             :.....:..||||.|||.|:..| :||....|:         ||::|| ||.|.|..:..:|..
  Rat   440 GIKVGDDKCFLVNLNADPALNELLVYYLKEHTLI---------GSANSQ-DIQLCGMGILPEHGI 494

  Fly   690 IEHERGGKLYVIPGSEDFETYVNGELLKDRRQLFHGDRLVIGGSHYFRISNPFCSQRGKADHP-- 752
            |:....|::.:.| .::..|:|||..:....||.||||::.|.:|:||::.|  .::.||:..
  Rat   495 IDIMPEGQVMLTP-QKNTRTFVNGSSVSSPIQLHHGDRILWGNNHFFRLNLP--KKKKKAEREDE 556

  Fly   753 ------------------------------VDFQLAHQEILQK------QEQQLRSEL----EAE 777
                                          .:|:.|..|:..|      ..|.:.|.|    |.|
  Rat   557 EREASLKNDSSSEQLDADGDSSSEVSSEINFNFEYAQMEVTMKALGSNDPMQSILSSLEQQHEEE 621

  Fly   778 KRAALTKIEQERAQHARDFE--------ERLQCLELEQFKYKCNSEMLETERQALALAQQQEHTP 834
            ||:||   |::|..:..:.|        ||..|..:::..:...|            |||:
  Rat   622 KRSAL---ERQRLMYEHELEQLRRRLSPERQNCRGVDRLSFHSPS------------AQQR---- 667

  Fly   835 LRH--EDAVSTPAQKSTILEDIQRIMLNPSEESLHKTQLMVKEATQRCRQLDLPLEFRQT-QTPD 896
            ||.  |:      :::|:...:.|:     .|.:.|..|:|:||:....:||...|::.| |.|
  Rat   668 LRQWAEE------REATLNNSLMRL-----REQIVKANLLVREASYIAEELDKRTEYKVTLQIP- 720

  Fly   897 EFGLLRTVILILDKQRGLKAEWPTARL-------GVWLDLVRDNAEQQEK--LNATTIFQSVEVD 952
                  ...|..:::||.....|..::       .:|      :.|:.|.  |:...::|    :
  Rat   721 ------ASSLDANRKRGSLLSEPAIQVRRKGKGKQIW------SLEKLENRLLDMRDLYQ----E 769

  Fly   953 WEPLDAD 959
            |:..:.|
  Rat   770 WKECEED 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	177/414 (43%)
		KISc	120..525	CDD:214526	176/413 (43%)
		Kinesin_assoc	524..657	CDD:292801	38/136 (28%)
		FHA	634..740	CDD:238017	38/106 (36%)
Kif13b	NP_998791.1	KISc_KIF1A_KIF1B	4..360	CDD:276816	177/414 (43%)
		KISc	6..360	CDD:214526	176/412 (43%)
		Kinesin_assoc	357..469	CDD:292801	38/135 (28%)
		FHA	447..544	CDD:238017	38/107 (36%)
		KIF1B	756..802	CDD:289208	5/25 (20%)
		C2	<888..>952	CDD:301316
		DUF3585	<1073..1143	CDD:304905
		DUF3694	<1211..1278	CDD:289256
		CAP_GLY	1644..1707	CDD:279625
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920