Protein Alignment neb and Kif3b

DIOPT Version :10

• Sequence 1: NP_476817.1
• Gene: neb / 35293
• FlyBaseID: FBgn0004374
• Length: 1121
• Species: Drosophila melanogaster
• Sequence 2: NP_001099999.1
• Gene: Kif3b / 296284
• RGDID: 1306815
• Length: 747
• Species: Rattus norvegicus
• Alignment Length: 962
• Identity: 255/962 - (26%)
• Similarity: 407/962 - (42%)
• Gaps: 268/962 - (27%)

  Fly   116 SEESNMIVAVRVRPLNALECTRGQVTNVVQVHGNSNELTVQ--AGSSADASAGVTHFFSYDQVYY 178
            |.||..:| ||.||:|..| .......||.|.....:::|:  .|:|.:    :...|::|.||
  Rat     6 SSESVRVV-VRCRPMNGKE-KAAAYDKVVDVDVKLGQVSVKNPKGTSHE----MPKTFTFDAVY- 63

  Fly   179 SCDPERKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGPP 243
              |...|.|    ::::.|.|||:|:..:|:|..:|||||||:||:|:|.|:.         |.|
  Rat    64 --DWNAKQF----ELYDETFRPLVDSVLQGFNGTIFAYGQTGTGKTYTMEGVR---------GDP 113

  Fly   244 HDEAGIIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQ 308
             ::.|:||.....:|..|...::||.|   |..||.|||.|:|.||||
  Rat   114 -EKRGVIPNSFDHIFTHISRSQNQQYL---VRASYLEIYQEEIRDLLS----------------- 157

  Fly   309 QQQQRPALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNI 373
             :.|...|:::|.|..|.||.|||:....|...:.:.:.|||..|:..:|.||:.|||||:||.|
  Rat   158 -KDQTKRLELKERPDTGVYVKDLSSFVTKSVKEIEHVMNVGNQNRSVGATNMNEHSSRSHAIFVI 221

  Fly   374 VLNLTDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINKSLL 438
            .:..:::    ||..:         ...|..|::|||||||||.:.:|:.|||::|...||.||.
  Rat   222 TVECSEV----GLDGE---------NHIRVGKLNLVDLAGSERQAKTGAQGERLKEATKINLSLS 273

  Fly   439 TLGKVIAALADSRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASIHAD 503
            .||.||:||.|.:             ||.:|||:|.||.||:::||||:||||:|.:.|||.:.:
  Rat   274 ALGNVISALVDGK-------------STHIPYRDSKLTRLLQDSLGGNAKTVMVANVGPASYNVE 325

  Fly   504 ETLATLRYACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSL-------RNEYERQRRLSGNSN 561
            |||.|||||.:|::|.|:.:|||.|.|.::|:.:.|:.|||:.       |.:...:||..|.|.
  Rat   326 ETLTTLRYANRAKNIKNKPRVNEDPKDALLREFQEEIARLKAQLEKRSIGRRKRREKRREGGGSG 390

  Fly   562 NPVPRKIIIETSVDETEVEALRQQLAERERELSRAQKSWMEKLKEAEDQRKSELRVLKRRGLALE 626
            .          ..:|.|.|.     .|.|.|.......|.|:      |.|.|:
  Rat   391 G----------GGEEEEEEG-----EEGEEEGDDKDDYWREQ------QEKLEI----------- 423

  Fly   627 LTAEQKQACLVNLTADPILSGTLFYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVALQHCSIE 691
                :|:|                                         ||.|..|||.:...:.
  Rat   424 ----EKRA-----------------------------------------IVEDHSLVAEEKMRLL 443

  Fly   692 HERGGKLYVIPGSEDFETYVNGELLKDRRQLFHGDRLVIGGSHYFRISNPFCSQRGKADHPVDFQ 756
            .|:..|:..:...:|     ..|:|..:.:... .:|::||.:.                 ||..
  Rat   444 KEKEKKMEDLRREKD-----AAEMLGAKIKAME-SKLLVGGKNI-----------------VDHT 485

  Fly   757 LAHQEILQKQEQQLRSELEAEKRAALTKIEQERAQHARDFEERLQCLELEQFKYKCNSEMLETER 821
            ...|:||:::.|::     ||::....:|:|:  ..:|| ||.|              |:.||
  Rat   486 NEQQKILEQKRQEI-----AEQKRREREIQQQ--MESRD-EETL--------------ELKET-- 526

  Fly   822 QALALAQQQEHTPLRHEDAVSTPAQKSTI--LEDIQRIMLNPSEESLHKTQLMVKEATQRCRQLD 884
                      :|.|:.|..:.|...|...  |:.::..:.:..||.:.:.|
  Rat   527 ----------YTSLQQEVDIKTKKLKKLFSKLQAVKAEIHDLQEEHIKERQ-------------- 567

  Fly   885 LPLEFRQTQTPDEFGLLRTVILILDKQRGLKAEWPTARLGVWLDLVRDN---AEQQEKLNATTIF 946
               |..|||.              :..|.||.:          .|:.:|   .|::.|:...:.|
  Rat   568 ---ELEQTQN--------------ELTRELKLK----------HLIIENFIPLEEKNKIMNRSFF 605

  Fly   947 QSVEVDWE--PLDADLNETLSDTHNSS---RIALNLSAMKDVLLN-KPLKRLLNASSSKSNTPRQ 1005
            ...|..|:  |:....|:.:.....|:   :..|:..|...:::. :|..|..|....:.:.|.:
  Rat   606 DDEEDHWKLHPITRLENQQMMKRPVSAVGYKRPLSQHARMSMMIRPEPRYRAENIMLLELDMPSR 670

  Fly  1006 TSTPSPG---SQLVHFTKRLLTYDPEEIPESQSSFTTLVQQELQIMQRSAQR 1054
            |:....|   |..|.........|.:||....|||.:...::.:...:|.::
  Rat   671 TTRDYEGPAISPKVQAALDAALQDEDEIQVDASSFESTANRKAKARPKSGRK 722

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	150/407 (37%)
		SMC_N	514..>615	CDD:481474	28/107 (26%)
		FHA_KIF14	627..741	CDD:438759	16/113 (14%)
Kif3b	NP_001099999.1	KISc_KIF3	8..340	CDD:276822	149/401 (37%)
		Smc	<355..>581	CDD:440809	69/390 (18%)