DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment neb and Kif28p

DIOPT Version :9

Sequence 1:	NP_476817.1	Gene:	neb / 35293	FlyBaseID:	FBgn0004374	Length:	1121	Species:	Drosophila melanogaster
Sequence 2:	NP_001257314.1	Gene:	Kif28p / 289309	RGDID:	1559696	Length:	1034	Species:	Rattus norvegicus

Alignment Length:	880	Identity:	251/880 - (28%)
Similarity:	377/880 - (42%)	Gaps:	206/880 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 LSVSEESNMIVAVRVRPLNALECTRGQVTNVVQVHGNSNELTVQAGSSADASAGVTHFFSYDQVY 177
            |.|....::.|||||||.:..|...|... |:.:|..|  :|::....|:    :...|::|..|
  Rat     9 LPVPRTDSVRVAVRVRPFSQREKNSGSQC-VISMHARS--ITIRDPKDAE----LVKTFTFDLAY 66

  Fly   178 YSCDPERKN-------------FACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMG 229
            :|.|..:|:             ||.|:.||....|.::|:|::||||.|.|||||||||||||:|
  Rat    67 WSHDGFQKDEDGVLIPSDPTSKFAGQSDVFHDIGRGILDSAWQGYNATLLAYGQTGSGKSYSMIG 131

  Fly   230 IEALDDAALDGGPPHDEAGIIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQH 294
            ..|             ..|||||.|.|||:.||  |.::.|:.:|..|..|||||:|.||||...
  Rat   132 YGA-------------NKGIIPRVCEELFQAIE--KQKESLEAQVMFSMLEIYNEQIRDLLSRTK 181

  Fly   295 AAAATGESTPIQQQQQQQRPALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTA 359
            |..                 .|:|||....|.:|..|.....:....:...:..|:..|.||||.
  Rat   182 APG-----------------GLRVREDQRLGFFVEGLKWVPCEDSVQIEKLVEQGSKIRMTASTN 229

  Fly   360 MNDKSSRSHSIFNIVLNLTDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNG 424
            ||..|||||.:  |.:....:..|..|              |::|.|::||||||||...|||.|
  Rat   230 MNASSSRSHML--IAIRFKQVFLDTAL--------------TKQSSINMVDLAGSERQRSSGSEG 278

  Fly   425 ERIREGVSINKSLLTLGKVIAALADSRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKT 489
            :|:|||..:|.||..||.||:||||         |..|.....:|||:||||.||:..|||||:|
  Rat   279 DRLREGSRVNLSLTNLGNVISALAD---------LAMGKKVLHIPYRDSVLTKLLQSALGGNSRT 334

  Fly   490 VMLATISPASIHADETLATLRYACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSLRNEYERQR 554
            .::|.:|||.|..:|||:|||||.:|:.:.||..:|..|   ::|..|||...|...
  Rat   335 TLIAALSPADICYEETLSTLRYAERAKKVRNRAVINTCP---LVRASRAENALLLGF-------- 388

  Fly   555 RLSGNSNNPVPRKIIIETSVDETEVEALRQQLAERERELSRAQKSWMEKLKEAEDQRKSELRVLK 619
               |.:.           :.:.:......|||.        ...:|.:.|::|..:.:.:...|
  Rat   389 ---GGAG-----------AAEHSACFWAEQQLG--------TWGTWAQLLEQARREWEQQYMAL- 430

  Fly   620 RRGLALELTAEQKQAC-----LVNLTADPILSGTLFYLLPQGLVRIGRGRLPGGSSSSQPDIVLD 679
                     |:::|..     |:|:..||.|:|.|.:.:..|...:||        ::...|.|.
  Rat   431 ---------AQEQQMVKILPHLLNVNEDPQLTGVLKFFIHNGSCEVGR--------AASNAICLQ 478

  Fly   680 GPLVALQHCSIEHERGGKLYVIPGSEDFETYVNGELLKDRRQLFHGDRLVIGGSHYFRISNPFCS 744
            ...::.:|.|..: ..||:.|.|.... :..|||..:..|.:|.|.||:::|.:..| :...|.|
  Rat   479 SLGISDKHASFTN-MDGKVTVAPHITG-KVIVNGVPVSSRTKLQHLDRIILGSNSAF-LYIGFPS 540

  Fly   745 QRGKAD-HPVDFQLAHQEILQKQEQQLRSELEAEKRAALTKIEQERAQHARDFEERLQCLELEQF 808
            :||..| ...|:.....|                 |||...:..:....|...:::.....|..|
  Rat   541 ERGAEDLGRFDYDFFQME-----------------RAAAEGVSVDMLGTASPGDDQADPSILAVF 588

  Fly   809 KYKCNSEMLETERQALALAQQQEHTPLRHEDAVSTPAQKSTILEDIQR-IMLNPSEESLHKT--- 869
            :.......|..|...::   ::....|:.|..|...|...:...|:|: :|:..:::..|:.
  Rat   589 QDYIKLMPLVVEANQMS---EELKKGLKMELKVKNLASSDSRGCDLQKEVMVKVTKQGTHEVWIW 650

  Fly   870 --------QLMVKEATQRCRQLDLPLEFRQT---QTPDEFGLLRTVILILDKQRGLKAEW---PT 920
                    :.:::|..||.      ||.|.:   |..|.|                   |   ..
  Rat   651 SKAKFINRKFLMEELYQRF------LESRDSHVAQEDDPF-------------------WDPVEV 690

  Fly   921 ARLG---VWLDLVRDN---AEQQEKLNATTIFQSV 949
            ..||   |||..:...   .||.|.||...:.::|
  Rat   691 LHLGSAHVWLQSLAHRMMLEEQVEFLNCEGLEEAV 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	160/418 (38%)
		KISc	120..525	CDD:214526	160/417 (38%)
		Kinesin_assoc	524..657	CDD:292801	24/137 (18%)
		FHA	634..740	CDD:238017	28/110 (25%)
Kif28p	NP_001257314.1	Motor_domain	15..370	CDD:277568	160/418 (38%)
		KISc	16..370	CDD:214526	160/417 (38%)
		FHA	<435..535	CDD:224630	29/110 (26%)
		FHA	440..537	CDD:238017	28/107 (26%)
		KIF1B	655..689	CDD:289208	10/58 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0245
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123768at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820