DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment neb and KIF13B

DIOPT Version :9

Sequence 1:	NP_476817.1	Gene:	neb / 35293	FlyBaseID:	FBgn0004374	Length:	1121	Species:	Drosophila melanogaster
Sequence 2:	XP_011542759.1	Gene:	KIF13B / 23303	HGNCID:	14405	Length:	1847	Species:	Homo sapiens

Alignment Length:	909	Identity:	294/909 - (32%)
Similarity:	443/909 - (48%)	Gaps:	202/909 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 ESNMIVAVRVRPLNALECTRGQVTNVVQVHGNSNELT-VQAGSSADASAGVTHFFSYDQVYYSCD 181
            :|.:.||||:||:|..| |......||.|..|...|. |....|...:.|....|:||..::|.|
Human     3 DSKVKVAVRIRPMNRRE-TDLHTKCVVDVDANKVILNPVNTNLSKGDARGQPKVFAYDHCFWSMD 66

  Fly   182 PE-RKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGPPHD 245
            .. ::.:|.|..||:.....::..||:|||||:||||||||||||:|||..             |
Human    67 ESVKEKYAGQDIVFKCLGENILQNAFDGYNACIFAYGQTGSGKSYTMMGTA-------------D 118

  Fly   246 EAGIIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQQ 310
            :.|:|||.|..||.|.:..::::| ..:|||||.||||||:.|||                 ..:
Human   119 QPGLIPRLCSGLFERTQKEENEEQ-SFKVEVSYMEIYNEKVRDLL-----------------DPK 165

  Fly   311 QQRPALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNIVL 375
            ..|..||||||.:.||||..||..:|.||..:.:.::.||..|..|:|.||::|||||::|.|.|
Human   166 GSRQTLKVREHSVLGPYVDGLSKLAVTSYKDIESLMSEGNKSRTVAATNMNEESSRSHAVFKITL 230

  Fly   376 NLTDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINKSLLTL 440
            ..|......|.|.:            :..|:||||||||||.:.:|:.|:|::||.:|||||.||
Human   231 THTLYDVKSGTSGE------------KVGKLSLVDLAGSERATKTGAAGDRLKEGSNINKSLTTL 283

  Fly   441 GKVIAALADSRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASIHADET 505
            |.||:||||..        .....:.|||||:|||||||:::|||||||.|:||:|||:.:.|||
Human   284 GLVISALADQS--------AGKNKNKFVPYRDSVLTWLLKDSLGGNSKTAMVATVSPAADNYDET 340

  Fly   506 LATLRYACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSLRNEYERQRRLSGNSNNPVPRKIII 570
            |:|||||.:|:.|||...|||.|:.:||||||.||::|:....:.|..:       :|
Human   341 LSTLRYADRAKHIVNHAVVNEDPNARIIRDLREEVEKLREQLTKAEAMK-------SP------- 391

  Fly   571 ETSVDETEVEALRQQLAERERELSRAQKSWMEKLKEAEDQRKSELRVLKRRGLALE---LTAEQK 632
                      .|:.:|.|.|:.:.....:|.|||::.|:..:...:.|:..|::|:   :.....
Human   392 ----------ELKDRLEESEKLIQEMTVTWEEKLRKTEEIAQERQKQLESLGISLQSSGIKVGDD 446

  Fly   633 QACLVNLTADPILSGTL-FYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVALQHCSIEHERGG 696
            :..||||.|||.|:..| :||....|:         ||::|| ||.|.|..:..:||.|:....|
Human   447 KCFLVNLNADPALNELLVYYLKEHTLI---------GSANSQ-DIQLCGMGILPEHCIIDITSEG 501

  Fly   697 KLYVIPGSEDFETYVNGELLKDRRQLFHGDRLVIGGSHYFRISNPFCSQRGKADH---------- 751
            ::.:.| .::..|:|||..:....||.||||::.|.:|:||::.|  .::.||:.
Human   502 QVMLTP-QKNTRTFVNGSSVSSPIQLHHGDRILWGNNHFFRLNLP--KKKKKAEREDEDQDPSMK 563

  Fly   752 --------PVD--------------FQLAHQEI----------LQKQEQQLRSELEAEKRAALTK 784
                    .||              ::.|..|:          :|.....|..:.|.|||:||
Human   564 NENSSEQLDVDGDSSSEVSSEVNFNYEYAQMEVTMKALGSNDPMQSILNSLEQQHEEEKRSAL-- 626

  Fly   785 IEQERAQHARDFE--------ERLQCLELEQFKYKCNSEMLETERQALALAQQQEHTPLRH--ED 839
             |::|..:..:.|        |:..|..:::|.:...|            |||:    ||.  |:
Human   627 -ERQRLMYEHELEQLRRRLSPEKQNCRSMDRFSFHSPS------------AQQR----LRQWAEE 674

  Fly   840 AVSTPAQKSTILEDIQRIMLNPSEESLHKTQLMVKEATQRCRQLDLPLEFRQT-QTPDEFGLLRT 903
                  :::|:...:.|:     .|.:.|..|:|:||.....:||...|::.| |.|       .
Human   675 ------REATLNNSLMRL-----REQIVKANLLVREANYIAEELDKRTEYKVTLQIP-------A 721

  Fly   904 VILILDKQRGLKAEWPTARL-------GVWLDLVRDNAEQQEKL-NATTIFQSVEVDWEPLDAD 959
            ..|..:::||.....|..::       .:|         ..||| |.....:.:..:|:..:.|
Human   722 SSLDANRKRGSLLSEPAIQVRRKGKGKQIW---------SLEKLDNRLLDMRDLYQEWKECEED 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	175/407 (43%)
		KISc	120..525	CDD:214526	174/406 (43%)
		Kinesin_assoc	524..657	CDD:292801	38/136 (28%)
		FHA	634..740	CDD:238017	39/106 (37%)
KIF13B	XP_011542759.1	KISc_KIF1A_KIF1B	4..360	CDD:276816	175/407 (43%)
		KISc	6..360	CDD:214526	174/405 (43%)
		Kinesin_assoc	357..469	CDD:292801	38/135 (28%)
		FHA	447..544	CDD:238017	39/107 (36%)
		RILP-like	<610..710	CDD:304877	30/129 (23%)
		KIF1B	756..802	CDD:289208	4/21 (19%)
		DUF3585	<1099..1143	CDD:304905
		DUF3694	<1221..1279	CDD:289256
		Jun	<1560..1664	CDD:281890
		CAP_GLY	1725..1788	CDD:279625
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920