DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment neb and KIF1B

DIOPT Version :9

Sequence 1:	NP_476817.1	Gene:	neb / 35293	FlyBaseID:	FBgn0004374	Length:	1121	Species:	Drosophila melanogaster
Sequence 2:	NP_001352880.1	Gene:	KIF1B / 23095	HGNCID:	16636	Length:	1816	Species:	Homo sapiens

Alignment Length:	925	Identity:	299/925 - (32%)
Similarity:	449/925 - (48%)	Gaps:	193/925 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 VAVRVRPLNALECTRGQVTNVVQVHGNSNELTVQAGSSADASAGVTHFFSYDQVYYS-CDPERKN 186
            |||||||.|:.| |..:...::|:.|||..: :...:..:|...    ||:|..|:| ..||...
Human     8 VAVRVRPFNSRE-TSKESKCIIQMQGNSTSI-INPKNPKEAPKS----FSFDYSYWSHTSPEDPC 66

  Fly   187 FACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGPPHDEAGIIP 251
            ||.|.:|:....:.::..||||||.|:|||||||:||||:|||.:           ...:|||||
Human    67 FASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQ-----------EESQAGIIP 120

  Fly   252 RFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQQQQRPAL 316
            :.|.|||.:|.. ...:::...|||||.|||.|::.|||:                  .:.:..|
Human   121 QLCEELFEKIND-NCNEEMSYSVEVSYMEIYCERVRDLLN------------------PKNKGNL 166

  Fly   317 KVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNIVLNLTDLS 381
            :|||||:.||||.|||..:|.||:.:.:.:..||..|..|:|.||:.|||||::|.||.......
Human   167 RVREHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKHD 231

  Fly   382 SDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINKSLLTLGKVIAA 446
            ::..||::            :.|||||||||||||...:|:.|.|::||.:|||||.||||||:|
Human   232 NETNLSTE------------KVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISA 284

  Fly   447 LADSRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASIHADETLATLRY 511
            ||:.....:.......|  .|:|||:|||||||||||||||:|.|:|.:|||.|:.||||:||||
Human   285 LAEVDNCTSKSKKKKKT--DFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRY 347

  Fly   512 ACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSL------------------------------ 546
            |.:|:.|.....:||.|:.|::|:|:.||.|||.|
Human   348 ADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRAQGLGDIIDIDPLIDDYSGSGSKYLKDF 412

  Fly   547 ---RNEY----ERQR-----RLSGNSNNPVPRKIIIETSVDETEVEALR-------------QQL 586
               ::.|    |.||     ..|..|....|....:.:.|..|.|.:::             ::|
Human   413 QNNKHRYLLASENQRPGHFSTASMGSLTSSPSSCSLSSQVGLTSVTSIQERIMSTPGGEEAIERL 477

  Fly   587 AERERELSRAQKSWMEKLKEAEDQRKSELRVLKRRGLA-------LELTAEQKQACLVNLTADPI 644
            .|.|:.::...::|.|||::.|..|.....:|...|:|       |.:.:.:|...||||..||:
Human   478 KESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIREDGGTLGVFSPKKTPHLVNLNEDPL 542

  Fly   645 LSGTLFYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVALQHCSIEHER---GGKLYVIPGSED 706
            :|..|.|.:..|:.|:|:     ..:..:.||||.|..:..:||....||   |..:..:...|.
Human   543 MSECLLYYIKDGITRVGQ-----ADAERRQDIVLSGAHIKEEHCIFRSERSNSGEVIVTLEPCER 602

  Fly   707 FETYVNGELLKDRRQLFHGDRLVIGGSHYFRISNPFCSQRGKAD-----------HPVDFQLAHQ 760
            .||||||:.:....||..|:|:::|.:|.||.::|   ::.:|:           .|||:..|.:
Human   603 SETYVNGKRVSQPVQLRSGNRIIMGKNHVFRFNHP---EQARAEREKTPSAETPSEPVDWTFAQR 664

  Fly   761 EILQKQEQQLRSELE--AEKRAALTKIEQERA-----QHARDFEERLQCLELEQFKYKCNSEMLE 818
            |:|:||...::.|:|  .::...|.|.|:|.|     |...|:|.:||.|:.:.......:|..|
Human   665 ELLEKQGIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLDYESKLQALQKQVETRSLAAETTE 729

  Fly   819 TERQALALAQQQEHTP-LRHEDAVST------PAQKSTILEDIQRIMLNPSEESLHKTQLMVKEA 876
            .|       :::|..| .:||..::.      .:.:.|.|.|:           |....:.:|||
Human   730 EE-------EEEEEVPWTQHEFELAQWAFRKWKSHQFTSLRDL-----------LWGNAVYLKEA 776

  Fly   877 TQRCRQLD----------------------LPLEFRQTQTPDEFGLLRTVIL--ILDKQRGLKAE 917
            .....:|.                      ||.|..:|.....|.  |||:.  :.|.:.|....
Human   777 NAISVELKKKVQFQFVLLTDTLYSPLPPELLPTEMEKTHEDRPFP--RTVVAVEVQDLKNGATHY 839

  Fly   918 WPTARLGVWLDLVRD 932
            |...:|...|||:|:
Human   840 WSLEKLKQRLDLMRE 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	172/402 (43%)
		KISc	120..525	CDD:214526	172/402 (43%)
		Kinesin_assoc	524..657	CDD:292801	45/194 (23%)
		FHA	634..740	CDD:238017	37/108 (34%)
KIF1B	NP_001352880.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	172/402 (43%)
		Interaction with KBP. /evidence=ECO:0000269\|PubMed:16225668	270..350		50/81 (62%)
		Kinesin_assoc	358..555	CDD:318424	45/196 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	431..450		3/18 (17%)
		FHA	532..636	CDD:238017	37/108 (34%)
		Prefoldin	662..717	CDD:324325	18/54 (33%)
		KIF1B	845..892	CDD:315155	5/10 (50%)
		DUF3694	1266..1413	CDD:315198
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1550..1570
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1617..1660
		PH_KIFIA_KIFIB	1697..1799	CDD:269939
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0245
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820