DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment neb and Kif18a

DIOPT Version :9

Sequence 1:	NP_476817.1	Gene:	neb / 35293	FlyBaseID:	FBgn0004374	Length:	1121	Species:	Drosophila melanogaster
Sequence 2:	XP_006499322.1	Gene:	Kif18a / 228421	MGIID:	2446977	Length:	919	Species:	Mus musculus

Alignment Length:	1132	Identity:	282/1132 - (24%)
Similarity:	428/1132 - (37%)	Gaps:	380/1132 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 GTGKSSCSRTKERDSLMESCLSVSEESNMIVAVRVRPLNALE-----CTRGQVTNVVQVHGNSNE 152
            ||.:..|.|.|                   |.|||||.|..|     |   :|.:||..|..|.:
Mouse     3 GTEEDLCHRMK-------------------VVVRVRPENTKEKAVQFC---KVVHVVDKHILSFD 45

  Fly   153 LTVQAGSSADASAGVTHF-----------FSYDQVYYSCDPERKNFACQAKVFEGTARPLIDTAF 206
             ..|...|.......|:|           |.:|.|:       ...:.|.:|||.|.:|::.:..
Mouse    46 -PKQEEISFFHRKKTTNFDITKRQNKDLKFVFDAVF-------DETSTQMEVFEHTTKPILHSFL 102

  Fly   207 EGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGPPHDEAGIIPRFCHELFRRIEAVKSQQQLQ 271
            .|||..:||||.|||||:::|:|..|             |.|::.....:||:.|:.:|.::  :
Mouse   103 NGYNCTVFAYGATGSGKTHTMLGSAA-------------EPGVMYLTMLDLFKCIDEIKEEK--E 152

  Fly   272 VEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQQQQRPALKVREHPIFGPYVVDLSAHSV 336
            ....|||.|:|||:|.|||:         .|.|           |.|||....|..|..|:.|..
Mouse   153 CSTAVSYLEVYNEQIRDLLT---------NSGP-----------LAVREDSQKGVVVQGLTLHQP 197

  Fly   337 DSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNIVLNLTDLSSDDGLSSDTDSSTASSLRQT 401
            .|...:...|..||..|....|.:|..|||||::|.|.|...|             .|||..:..
Mouse   198 KSSEEILQLLDNGNKNRTQHPTDVNAVSSRSHAVFQIYLRQQD-------------KTASINQNV 249

  Fly   402 RRSKISLVDLAGSERISVSGSNGERIREGVSINKSLLTLGKVIAALADSRKAIANGPLGSGTPST 466
            |.:|:||:|||||||.||||:.|.|..||.:||||||.||.||.|||::::.           :.
Mouse   250 RIAKMSLIDLAGSERASVSGAKGSRFVEGTNINKSLLALGNVINALANTKRR-----------NQ 303

  Fly   467 FVPYRESVLTWLLRENLGGNSKTVMLATISPASIHADETLATLRYACKARSIVNRVKVNE----- 526
            .:|||.|.||.||:::||||.:|:|:|.:||:|:..|:|..||:||.:|:.|.:.:|.|.
Mouse   304 HIPYRNSKLTRLLKDSLGGNCQTIMIAAVSPSSLFYDDTYNTLKYANRAKEIKSSLKSNVLNLNS 368

  Fly   527 --SPHDKIIRDLRAEVDRLKSLRNEYERQRRLSGNS-------NNPVPRKIIIETSVDETE---- 578
              |.:.||....:||:..||.....||.|:.||..:       :||..|         |||
Mouse   369 HISQYVKICNMQKAEILMLKEKLKAYEEQKALSDRNDCAKLVHSNPEDR---------ETERFQE 424

  Fly   579 --------VEALRQQLAEREREL-SRAQKSWM--------------EKLKEAEDQRKSELRVLKR 620
                    .|.:||:..:.|..| :.|.||..              :|:::|..:|...|..||.
Mouse   425 ILNCLFQNREGIRQEYLKLEMLLKANALKSSYHQQCHKQIEMMCSEDKVEKATCKRDHRLEKLKT 489

  Fly   621 RGLALELTAEQKQACLVNLTADPILSGTLFYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVAL 685
            ....||...|:                                      .|.|.|
Mouse   490 NSCFLEKKKEE--------------------------------------VSKQFD---------- 506

  Fly   686 QHCSIEHERGGKLYVIPGSEDFETYVNGELLKDRRQLFHGDRLVIGGSHYFRISNPFCSQRGKAD 750
            ::.:..|....::.::..:.|....:|.||        |        .|:..:.|
Mouse   507 ENTNWLHRVENEMRLLGQNGDIPEALNKEL--------H--------CHHLHLQN---------- 545

  Fly   751 HPVDFQLAHQEILQKQEQQLRSELEAEKRAALT-------KIEQERAQHA------RDFEERLQC 802
            ..:..|:||...|...::|...:.||...|.|.       |:::....:|      :|.|..::.
Mouse   546 KELKTQMAHMTALACLQEQQHKQTEAVLNALLPVLRKQYWKLKETGLSNAAFDSDFKDIEHLVER 610

  Fly   803 LELEQFKYKCNSE----------------MLE-----------TERQALALAQQQE------HTP 834
            .::..:..:.|..                .||           ::...|.|..|:.      .:|
Mouse   611 KKVVAWADQTNEHSNRNDLPGISLLMTFPQLEPIQSISCCTSVSDPNVLKLTPQRRTRRKIIPSP 675

  Fly   835 LRHEDAVSTPAQKSTILED-----IQRIMLNPSE--------ESLHKTQL----MVKEATQR--C 880
            |:.:....:...:||.|.|     :|.|:..|.:        .||.:|..    ::.:.:|:  |
Mouse   676 LKVQHTQKSALSESTQLNDSFSKELQPIVYTPEDCKKAQDLFPSLTRTSSQSANVMNDNSQKALC 740

  Fly   881 RQLDLPLEFRQTQTPDEFGLLRTVILILDKQRGLKAEWPTARLGVWLDLVRDNAEQQEKLNATTI 945
            | ::.||    ::|..:.||..|..| .|..||||.:||               ||
Mouse   741 R-IESPL----SRTECKQGLYSTSTL-CDSIRGLKNKWP---------------EQ--------- 775

  Fly   946 FQSVEVDWEPLDADLNETLSDTHNSSRIALNLSAMKD-----------VLLNKPLKRLLNASSSK 999
                    |||.:    :.|..|   ||..:..:.||           :.:....||.....||.
Mouse   776 --------EPLAS----SKSSVH---RIESSSFSTKDSMPESAGVPSYMAMTTAAKRKWKQMSST 825

  Fly  1000 SNTPRQTSTPSPGSQLVHFTKRL----LTYDP---------EEIPESQSSFTTLVQQELQIMQRS 1051
            ||...: |..|.|     |.||:    .:..|         :|||..|  ..|.::...:.:|:.
Mouse   826 SNASIK-SDESCG-----FAKRIRRDNSSVKPMQENRLKAIKEIPTKQ--IQTCLENLEETLQKK 882

  Fly  1052 AQRLRRHCEAAL---LE------RENH 1069
            ....:..|...:   ||      :|.|
Mouse   883 MYNKKNQCPCVVFMPLEMYFKSGKEGH 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	147/421 (35%)
		KISc	120..525	CDD:214526	147/420 (35%)
		Kinesin_assoc	524..657	CDD:292801	36/173 (21%)
		FHA	634..740	CDD:238017	10/105 (10%)
Kif18a	XP_006499322.1	KISc_KIP3_like	11..355	CDD:276821	147/432 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000