Protein Alignment neb and klp-4

DIOPT Version :9

• Sequence 1: NP_476817.1
• Gene: neb / 35293
• FlyBaseID: FBgn0004374
• Length: 1121
• Species: Drosophila melanogaster
• Sequence 2: NP_001359864.1
• Gene: klp-4 / 180608
• WormBaseID: WBGene00002217
• Length: 1576
• Species: Caenorhabditis elegans
• Alignment Length: 1130
• Identity: 319/1130 - (28%)
• Similarity: 501/1130 - (44%)
• Gaps: 277/1130 - (24%)

  Fly   117 EESNMIVAVRVRPLNALECTRGQVTNVVQVHGNSNEL--TVQAGSSADASAGVTHFFSYDQVYYS 179
            |||.:.||:||||.|..|... :..:||::......|  .::..:|..        |::|..:.|
 Worm     6 EESAVKVAIRVRPFNKRELDL-KTKSVVRIQKEQCVLHHPIEEKNSKT--------FTFDHSFCS 61

  Fly   180 CDPERKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGPPH 244
            .||...:||.|..|.......:::.||.|||||:||||||||||||:|||..
 Worm    62 TDPHSYDFASQETVSYHLGSGVVENAFSGYNACIFAYGQTGSGKSYTMMGTP------------- 113

  Fly   245 DEAGIIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQ 309
            |:.|||||.|:::|.||:.. |...|..:|||||.|||||::.|||                 ..
 Worm   114 DQPGIIPRVCNDIFTRIQET-SNSSLSFKVEVSYMEIYNERVRDLL-----------------DP 160

  Fly   310 QQQRPALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNIV 374
            ::...|||||||.|.||.|..||..:|:|:..:.|.|..||..|..|:|.||.:|||||::|:::
 Worm   161 KKSSKALKVREHKILGPMVDGLSILAVNSFEQISNLLEEGNKSRTVAATNMNAESSRSHAVFSLI 225

  Fly   375 LNLTDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINKSLLT 439
            :..|....::|.|.:            :.:||||||||||||...:|:.|:|:.||.:|||||.|
 Worm   226 VTQTLHDLENGFSGE------------KVAKISLVDLAGSERAGKTGAVGKRLEEGGNINKSLTT 278

  Fly   440 LGKVIAALAD--SRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASIHA 502
            ||.||:|||:  |:|            ..|:|||:|||||||:::|||||:|||:||:|||:.:.
 Worm   279 LGMVISALAERNSKK------------DKFIPYRDSVLTWLLKDSLGGNSRTVMIATLSPAADNY 331

  Fly   503 DETLATLRYACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSLRNEYERQRRLSGNSNNPVPRK 567
            :|||:|||||.:|:.|||...:||.|:.::||:||.||:.|                      |.
 Worm   332 EETLSTLRYADRAKKIVNHAIINEDPNARVIRELREEVETL----------------------RM 374

  Fly   568 IIIETSVDETEVEALRQQLAERERELSRAQKSWMEKLKEAEDQRKSELRVLKRRGLALE---LTA 629
            .|.:|..:..|.|.||::|||.||.:::..|||.|:|||.:...|...:.|...|:::|   :..
 Worm   375 QITQTKKEHAETEELRERLAESERLVAQMNKSWEERLKETDTLNKERQKDLTEIGISIESSGIKV 439

  Fly   630 EQKQACLVNLTADPILSGTLFYLLPQGLVRIGR----------GRLPGGSSSSQPD-------IV 677
            |:.:..|||:.|||.|:..|.|.: .|...||.          |.....|.||:.|       ||
 Worm   440 EKDRFYLVNMNADPSLNELLVYYI-NGSAIIGNSEELETSRDSGLSMTCSDSSRRDDDKERTSIV 503

  Fly   678 LDGPLVALQHCSIE-HERGG--KLYVIPGSEDFETYVNGELLKDRRQLFHGDRLVIGGSHYFRIS 739
            |.|..:..:|..:. .|.||  :|:|.|.|.:....|||:.:.:|..|.:|:||::|.:|:|:::
 Worm   504 LRGLGIMRRHAKMTVEEYGGRLRLFVAPMSSECRICVNGKQITERTLLRNGNRLLVGMNHFFKVN 568

  Fly   740 NP---FCSQRGKADHPV-DFQLAHQEI---------LQKQEQQLRSELEAEKRAALTKIEQERAQ 791
            .|   ...|....|..: |:..|..|:         :.:..:.:..:.:.:|:|||       .|
 Worm   569 CPKVMDMEQSIMEDSTMFDYNDAWHEVNDANPISSAVDQYMESVTLKHQEDKKAAL-------EQ 626

  Fly   792 HARDFEERLQ-----------------CLE--------LEQFKYKCNSEMLETERQALALAQQQE 831
            ....||:.:|                 ||.        |..|.:..|.:. ..:.:....||::|
 Worm   627 QYEAFEKYIQSLTAGGFTPSTPMTPGFCLPTPITTPTGLPPFPFPANPKQ-SVKSKFFYWAQRKE 690

  Fly   832 H----------TPLRHEDAVSTPAQKSTILEDIQRIMLNPSEESLHKTQLMVKEATQRCRQLDLP 886
            .          ..:.|.:|:...|  :.|.:::.:   .|..::.:...|.:..:..|      |
 Worm   691 EMFAESLKRLKADVIHANALVREA--NMISKELNK---KPKRQTTYDVTLQIPASNLR------P 744

  Fly   887 LEFRQTQTPDEFGLLRTVILILDKQRGLKAE--WPTARL--------GVWLDLVRDNAEQQEKLN 941
            ::.:..|.     :...||::  ::.|:...  |..::|        ..:.|::.......|.||
 Worm   745 IKIKAGQF-----VCEPVIVV--RREGMSGSQFWTVSQLESRLVDMRDTYNDMLNGFTRTSESLN 802

  Fly   942 AT------------------------------------------TIFQSVEVDWE-PLDADLNET 963
            .|                                          .:|..:.:|:: |:.:...|.
 Worm   803 GTPHASPMKIAGIPMNECSSLVIDPFFESQEHHNLVGVANVFLEVLFHDLRLDYQVPIISQQGEV 867

  Fly   964 LSDTHNSSRIALNLSAMKDVLLNKPLKRLLNASSSKSNTPRQTSTPSPGSQLV-------HFTKR 1021
            ....|......:....|.:...|.|...|....:.:....|.:..|...|..|       :.::.
 Worm   868 AGRLHVQIFRVVTQEEMDETSNNGPETLLGKTITCRVRIKRASGLPEKLSNFVFCQYSFFNISEL 932

  Fly  1022 LLTYDPEE-----------IPESQSSFTTLVQQELQIMQRS--------AQRLRRHCEAALLERE 1067
            |:.....|           |.|.|..|..:|.:|.....|.        ..|:..|.|..:|:.:
 Worm   933 LVVAPANEAANHSSCPTTVIFEHQRDFNVMVTEEFMEYVRDDALSIEVWGHRICGHPEERILDTD 997

  Fly  1068 NHQDNGVLAVSLQ----EALARMDT 1088
            ..      :.|||    |...|::|
 Worm   998 EK------SKSLQNRWMEVTRRLET 1016

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	170/409 (42%)
		KISc	120..525	CDD:214526	169/408 (41%)
		Kinesin_assoc	524..657	CDD:292801	43/135 (32%)
		FHA	634..740	CDD:238017	40/125 (32%)
klp-4	NP_001359864.1	KISc_KIF1A_KIF1B	10..354	CDD:276816	169/407 (42%)
		Kinesin_assoc	351..463	CDD:374417	43/133 (32%)
		FHA	496..545	CDD:214578	15/48 (31%)
		KIF1B	776..840	CDD:372100	6/63 (10%)
		DUF3694	<1239..1293	CDD:372133

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920