Protein Alignment neb and klp-11

DIOPT Version :10

• Sequence 1: NP_476817.1
• Gene: neb / 35293
• FlyBaseID: FBgn0004374
• Length: 1121
• Species: Drosophila melanogaster
• Sequence 2: NP_001369897.1
• Gene: klp-11 / 177685
• WormBaseID: WBGene00002222
• Length: 782
• Species: Caenorhabditis elegans
• Alignment Length: 973
• Identity: 239/973 - (24%)
• Similarity: 404/973 - (41%)
• Gaps: 264/973 - (27%)

  Fly   108 LMESCLSVSEESNMIVAVRVRPLNALECTRGQVTNVVQVHGNSNELTVQAGSSADASAGVTHFFS 172
            ::|.....|::..:.|.||.|||::.|.. ...:.:|.:.....::.::.....|..   :..|:
 Worm     1 MVEIMKKSSKQETVKVIVRCRPLSSQEIA-NNYSKIVHMRPQRGQIELKNPKEQDEP---SKDFT 61

  Fly   173 YDQVYYSCDPERKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAA 237
            :|.:|       ...:.|:.::|.|.|.|:|:...||||.:|||||||:||:::|.|
 Worm    62 FDAIY-------DENSTQSDLYEETFRDLVDSVLNGYNATIFAYGQTGTGKTHTMEG-------- 111

  Fly   238 LDGGPPHDEAGIIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGES 302
             ....| ::.|:|.:....:|..:.|..:|:.|   |..||.|||.|::.|||
 Worm   112 -KSSDP-EQRGVIYKCIDHIFEHMAASHNQEYL---VRASYLEIYQEELRDLL------------ 159

  Fly   303 TPIQQQQQQQRPALKVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRS 367
                  :.:....|:::|.|..|.||.||::....:...:...:..||..|:...|.||:.||||
 Worm   160 ------EAESNKKLEIKERPDGGVYVKDLTSKLTRTVGEIHEVMIRGNGHRSVGRTNMNEHSSRS 218

  Fly   368 HSIFNIVLNLTDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVS 432
            |:||.|.:..:.: .:||.|..|            ..:::|||||||||.|.:|:.|||.:|...
 Worm   219 HAIFIITVECSRI-GEDGESHIT------------VGRLNLVDLAGSERQSKTGATGERFKEATK 270

  Fly   433 INKSLLTLGKVIAALADSRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISP 497
            ||.||..||.||:||.|::             |..:|||:|.||.||:::|||||||||:|.|.|
 Worm   271 INLSLSALGNVISALVDAK-------------SAHIPYRDSKLTRLLQDSLGGNSKTVMVACIGP 322

  Fly   498 ASIHADETLATLRYACKARSIVNRVKVNESPHDKIIRDLRAEVDRLK-SLRNEYERQRRLSGNSN 561
            ||.:.:|||.|||||.:|::|.|:.|:||.|.|.::|:.:.|::.|: .|:....|.|..:..|.
 Worm   323 ASYNFEETLGTLRYANRAKNIKNQPKINEDPKDALLREFQEEIEMLREQLKQRKTRSRDGATQSF 387

  Fly   562 NPVPRKIIIETSVDETEVEALRQQLAERERELSRAQKSWMEKLKEAEDQRKSELRVLKRRGLALE 626
            ....|..:      |.::||:::..:..:.|..|..:...||....|.:|..:.||.:|
 Worm   388 YDAERAKL------EDDIEAIQKDDSLIKHEKDRLIREIQEKHDLLEKERIEQARVAER------ 440

  Fly   627 LTAEQKQACLVNLTADPILSGTLFYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVAL---QHC 688
                     :.|:                      :.||..||..       ||.|.:.   ||.
 Worm   441 ---------IANI----------------------QSRLIVGSEE-------DGRLESRTKEQHA 467

  Fly   689 SIEHERGGKLYVIPGSEDFETYVNGELLKDRRQLFHGDRLVIGGSHYFRISNPFCSQRGKADHPV 753
            .:|.:|                  .||.:.:|:    :|.::
 Worm   468 QLEKKR------------------RELAEQKRR----EREMV----------------------- 487

  Fly   754 DFQLAHQEILQKQEQ----------QLRSELEAEK---RAALTKIEQER----------AQHARD 795
                   |.|::||:          .||:|:||:.   :..|.|:.|.|          :...:|
 Worm   488 -------EALERQEEDTVDLKQTFSDLRTEVEAKTKKLKKMLIKLRQARNEIRDVSGAYSDERQD 545

  Fly   796 FEE---------RLQCLELEQF-----------KYKCNSEMLETERQALALAQQQEHTPLR---- 836
            .::         :|:.|.:|.|           :.:.|.:..|....|.........|||.
 Worm   546 LDQTIAEVSKELKLKLLIVENFIPRDVSERIKERAEWNEDSFEWNVNAFQSTSSNSSTPLNNTIE 610

  Fly   837 -HEDAVSTPAQKSTILEDIQRIMLNPSEESLHKTQLMVKE--ATQRCRQLDLPLEFRQTQTPDEF 898
             :||.|.|.:..:.     ..:.::....:...:|.:.|.  ||..||:   |:...:
 Worm   611 VNEDGVFTRSSGAD-----SGVSVSGGNGTPATSQFLDKRLVATPGCRR---PMSMCE------- 660

  Fly   899 GLLRTVILILDKQRGLKAEWPTARLGVWL------DLVRDNAEQQEKLNATTIFQSVEVDWEPLD 957
               |.::....:|.|.:...|.:..|.::      :.:|...|.....:|...|.....|.:|
 Worm   661 ---RMLVETAREQFGAQRRPPISGSGSFVEATIPEETIRFCGENVVVFSALERFVPEVTDSDP-- 720

  Fly   958 ADLNETLSDTHNSSRIALNLSAMKDVLL--NKPLKRLLNAS-----SSKSNTPRQTSTPSPGS 1013
                   |...||..::....:::::.:  :|.|..:||.|     :||:...|..:.|..||
 Worm   721 -------STFSNSMMMSARRPSIENLTIDASKVLVPILNQSTMILKNSKNGQARNDTMPPNGS 776

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	137/405 (34%)
		SMC_N	514..>615	CDD:481474	25/101 (25%)
		FHA_KIF14	627..741	CDD:438759	16/116 (14%)
klp-11	NP_001369897.1	Motor_domain	12..343	CDD:473979	134/398 (34%)
		Smc	<358..>558	CDD:440809	50/301 (17%)